Amorphous alloys show potential as implant materials due to their superior mechanical properties and good corrosion resistance. However, the presence of toxic elements in the alloy composition can pose challenges, as they can react with the surrounding tissue, leading to inflammation and cell death. To address this, TiCuZrFeSnAg at% amorphous alloy is developed. This composition comprises of biocompatible elements (Ti, Zr, and Sn) and antimicrobial elements (Ag, Fe, and Cu), for potential use as implant materials. Chemical pseudo-dealloying using a solution of ammonium hydroxide and hydrogen peroxide is employed to selectively remove copper from the sample surface, which may induce toxicity by prolonged contact, and promote the formation of a patterned passivating Ti/Zr oxide-rich surface to enable possible antimicrobial effects. The surface of the samples was analyzed using atomic force microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. The modified surfaces show titanium oxide-rich nanostructured topography with depleted amounts of copper from the surface. The kinetics of the selective removal of copper, and the influence of parameters such as electrolyte concentration, immersion time, and stirring velocity on the evolution of morphology were investigated. Our findings elucidate the mechanism of pseudo-dealloying using an ammonia-based solution and demonstrate its efficacy in enhancing the biocompatibility of the alloy. In detail, the pseudo-dealloyed samples exhibited hydrophilic interactions and demonstrated hemocompatibility, making them promising candidates for blood-contacting medical devices. This study underscores the significance of our approach in tailoring the surface properties of amorphous alloys for biomedical applications, paving the way for their utilization in implant materials with improved biocompatibility.

中文翻译：

---

通过碱性化学处理制备 Ti40Cu40Zr11Fe3Sn3Ag3 非晶合金的表面纳米结构，有望用作生物相容性材料


非晶合金由于其优越的机械性能和良好的耐腐蚀性而显示出作为植入材料的潜力。然而，合金成分中有毒元素的存在可能会带来挑战，因为它们会与周围组织发生反应，导致炎症和细胞死亡。为了解决这个问题，开发了 TiCuZrFeSnAg at% 非晶合金。该组合物包含生物相容性元素（Ti、Zr 和 Sn）和抗菌元素（Ag、Fe 和 Cu），可用作植入材料。使用氢氧化铵和过氧化氢溶液进行化学假脱合金，选择性地去除样品表面的铜（长时间接触可能会产生毒性），并促进图案化钝化富钛/锆氧化物表面的形成，从而使铜成为可能。抗菌作用。使用原子力显微镜、扫描电子显微镜和X射线光电子能谱分析样品的表面。改性表面显示出富含氧化钛的纳米结构形貌，并且表面的铜含量已耗尽。研究了选择性去除铜的动力学，以及电解质浓度、浸泡时间和搅拌速度等参数对形貌演变的影响。我们的研究结果阐明了使用氨基溶液进行伪脱合金的机制，并证明了其在增强合金生物相容性方面的功效。具体来说，假脱合金样品表现出亲水相互作用并表现出血液相容性，使它们成为血液接触医疗器械的有希望的候选者。 这项研究强调了我们的方法在为生物医学应用定制非晶合金表面性能方面的重要性，为它们在具有改善的生物相容性的植入材料中的应用铺平了道路。