An efficient and sensitivity approach, which combines solid-phase extraction or ultrasonic extraction for pretreatment, followed by ultra-performance liquid chromatography-tandem mass spectrometry, has been established to simultaneously determine eight lipophilic phycotoxins and one hydrophilic phycotoxin in seawater, sediment and biota samples. The recoveries and matrix effects of target analytes were in the range of 61.6–117.3 %, 55.7–121.3 %, 57.5–139.9 % and 82.6 %–95.0 %, 85.8–106.8 %, 80.7 %–103.3 % in seawater, sediment, and biota samples, respectively. This established method revealed that seven, six and six phycotoxins were respectively detected in the Beibu Gulf, with concentrations ranging from 0.14 ng/L (okadaic acid, OA) to 26.83 ng/L (domoic acid, DA) in seawater, 0.04 ng/g (gymnodimine-A, GYM-A) to 2.75 ng/g (DA) in sediment and 0.01 ng/g (GYM-A) to 2.64 ng/g (domoic acid) in biota samples. These results suggest that the presented method is applicable for the simultaneous determination of trace marine lipophilic and hydrophilic phycotoxins in real samples.

中文翻译：

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同时测定各种环境和生物基质中的痕量海洋亲脂性和亲水性藻毒素

建立了一种高效、灵敏的方法，结合固相萃取或超声萃取进行预处理，然后采用超高效液相色谱-串联质谱法，同时测定海水、沉积物和生物群样品中的八种亲脂性藻毒素和一种亲水性藻毒素。 。海水、沉积物和沉积物中目标分析物的回收率和基质效应范围为 61.6–117.3 %、55.7–121.3 %、57.5–139.9 % 和 82.6 %–95.0 %、85.8–106.8 %、80.7 %–103.3 %。分别是生物群样本。建立的方法显示，北部湾海域分别检出7种、6种和6种藻类毒素，海水中浓度范围为0.14 ng/L（冈田酸，OA）至26.83 ng/L（软骨藻酸，DA），0.04 ng/L。沉积物中的 g（裸二胺-A、GYM-A）至 2.75 ng/g（DA），生物群样品中的 0.01 ng/g（GYM-A）至 2.64 ng/g（软骨藻酸）。这些结果表明，该方法适用于同时测定实际样品中痕量海洋亲脂性和亲水性藻毒素。