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Prevalence and Genetic Diversity of Adenovirus 40/41, Astrovirus, and Sapovirus in Children with Acute Gastroenteritis in Kansas City 2011-2016
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2024-05-08 , DOI: 10.1093/infdis/jiae251
Marta Diez-Valcarce 1, 2 , Jennifer L Cannon 1, 2 , Hannah Browne 1, 2 , Kenny Nguyen 1, 2 , Christopher J Harrison 3 , Mary E Moffatt 3 , Kirsten Weltmer 3 , Brian R Lee 3 , Ferdaus Hassan 3 , Debarpan Dhar 3 , Mary E Wikswo 1 , Daniel C Payne 1 , Aaron T Curns 1 , Rangaraj Selvarangan 3 , Jan Vinjé 1
Affiliation  

Background Most U.S. acute gastroenteritis (AGE) episodes in children are attributed to norovirus, whereas very little information is available on adenovirus 40/41 (AdV40/41), astrovirus or sapovirus. The New Vaccine Surveillance Network (NVSN) conducted prospective, active, population-based AGE surveillance in young children. Methods We tested and typed stool specimens collected between December 2011 to June 2016 from one NVSN site in Kansas City for the three viruses, and calculated hospitalization and emergency department (ED) detection rate. Results Of 3,205 collected specimens, 2,453 (76.5%) were from AGE patients (339 inpatients and 2,114 ED patients) and 752 (23.5%) were from healthy controls (HC). In AGE patients, astrovirus was detected in 94 (3.8%), sapovirus in 252 (10.3%) and AdV40/41 in 101 (4.5%) of 2249 patients. In HC, astrovirus was detected in 13 (1.7%) and sapovirus in 15 (2.0%) specimens. Astrovirus type 1 (37.7%) and genogroup I sapoviruses (59.3%) were most prevalent. Hospitalization rates were 5 (AdV40/41), 4 (astrovirus) and 8 (sapovirus) per 100,000 children <11 years old, whereas ED rates were 2.4 (AdV40/41), 1.9 (astrovirus) and 5.3 (sapovirus) per 1000 children <5 years old. Conclusions Overall, AdV40/41, astrovirus, and sapovirus were detected in 18.6% of AGE in a large pediatric hospital in Kansas City.

中文翻译:

2011-2016 年堪萨斯城急性胃肠炎儿童中腺病毒 40/41、星状病毒和沙波病毒的患病率和遗传多样性

背景 大多数美国儿童急性胃肠炎 (AGE) 发作归因于诺如病毒,而有关腺病毒 40/41 (AdV40/41)、星状病毒或沙波病毒的信息很少。新疫苗监测网络 (NVSN) 对幼儿进行前瞻性、主动的、基于人群的 AGE 监测。方法 我们对 2011 年 12 月至 2016 年 6 月期间从堪萨斯城一个 NVSN 站点收集的粪便标本进行了这三种病毒的检测和分型,并计算了住院和急诊室 (ED) 的检出率。结果 在收集的 3,205 份标本中,2,453 份(76.5%)来自 AGE 患者(339 名住院患者和 2,114 名 ED 患者),752 份(23.5%)来自健康对照 (HC)。在 AGE 患者中,2249 名患者中,94 名患者(3.8%)检测到星状病毒,252 名患者(10.3%)检测到沙波病毒,101 名患者(4.5%)检测到 AdV40/41。在 HC 中,13 个样本(1.7%)检测到星状病毒,15 个样本(2.0%)检测到沙波病毒。 1 型星状病毒 (37.7%) 和基因组 I 沙波病毒 (59.3%) 最常见。住院率为每 100,000 名 11 岁以下儿童 5 例 (AdV40/41)、4 例(星状病毒)和 8 例(沙波病毒),而 ED 率为每 1000 例 2.4 例 (AdV40/41)、1.9 例(星状病毒)和 5.3 例(沙波病毒) 5岁以下的儿童。结论 总体而言,堪萨斯城一家大型儿科医院 18.6% 的 AGE 中检测到了 AdV40/41、星状病毒和沙波病毒。
更新日期:2024-05-08
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