Using single-cell RNA and T cell receptor sequencing along with microscopy, we identified the cell types and genes associated with immune checkpoint inhibitor therapy-related colitis. Our study will help to identify targets for early diagnosis and lays the groundwork for the development of safer immunotherapy regimens.

中文翻译：

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研究配对的患者组织和血液可以深入了解免疫疗法的毒性

通过单细胞 RNA 和 T 细胞受体测序以及显微镜检查，我们确定了与免疫检查点抑制剂治疗相关结肠炎相关的细胞类型和基因。我们的研究将有助于确定早期诊断的目标，并为开发更安全的免疫治疗方案奠定基础。