Hydrogen peroxide (H₂O₂) has gained widespread utility in green chemical synthesis. H₂O₂-mediated tandem catalysis combines the two-electron oxygen reduction reaction (2e^– ORR) and organics oxidation, which enables the in situ conversion of organics and the in situ production/utilization of H₂O₂ within the same system. This method not only reduces the cost of H₂O₂ purification and transportation but also promotes in-depth research in the renewable manufacturing of high-value-added chemicals. As such, this review will encompass the critical initial discoveries guiding H₂O₂-mediated tandem catalysis and discuss the core contents such as the tandem mechanism, applicable substrates, and electrolysis modes. Design principles and research efforts are highlighted from the aspects of bifunctional catalyst design, multistep catalysis matching, reactor integration and innovation, and system expansion. Finally, we provide personal perspectives on the challenges in this burgeoning field and the strategies that can be employed to render tandem processes practically feasible.

过氧化氢（H ₂ O ₂）在绿色化学合成中得到了广泛的应用。 H ₂ O ₂介导的串联催化结合了双电子氧还原反应(2e ^– ORR)和有机物氧化反应，能够在同一系统内实现有机物的原位转化和H ₂ O _2的原位生产/利用。该方法不仅降低了H ₂ O ₂纯化和运输的成本，而且促进了高附加值化学品的可再生制造的深入研究。因此，本综述将涵盖指导H ₂ O ₂介导串联催化的关键初步发现，并讨论串联机制、适用底物和电解模式等核心内容。从双功能催化剂设计、多步催化匹配、反应器集成与创新、系统扩展等方面重点阐述了设计原理和研究工作。最后，我们对这个新兴领域面临的挑战以及可用于使串联过程切实可行的策略提供个人观点。