An efficient approach was developed for the synthesis of the well-known BlueCage by pre-bridging two 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPT) panels with one linker followed by cage formation in a much improved yield and shortened reaction time. Such a stepwise methodology was further applied to synthesize three new pyridinium organic cages, C2, C3, and C4, where the low-symmetry cages C3 and C4 with angled panels demonstrated better recognition properties toward 1,1′-bi-2-naphthol (BINOL) than the high-symmetry analogue C2 featuring parallel platforms.

中文翻译：

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低对称性六阳离子吡啶有机笼的逐步合成

我们开发了一种有效的方法来合成著名的 BlueCage，即通过一个连接器预桥接两个 2,4,6-三(4-吡啶基)-1,3,5-三嗪 (TPT) 面板，然后形成笼大大提高了产率并缩短了反应时间。这种逐步方法被进一步应用于合成三种新的吡啶有机笼C2、C3和C4，其中带有角度面板的低对称性笼C3和C4对 1,1'-bi-2-naphthol 表现出更好的识别性能（ BINOL）比具有并行平台的高对称性模拟C2更好。