A novel Pd-catalyzed three-component domino reaction for the stereoselective synthesis of highly functionalized allyl cinnamates has been developed. In this protocol, a sequential process of C–C bond activation and intermolecular allylic substitution was well-organized. The key for this transformation is the in situ generated hydrolysis product of cyclopropenone, which triggered a new reaction with vinylethylene carbonates. The reaction mechanism was investigated, demonstrating the high stereoselectivity and excellent atomic economy in this process.

中文翻译：

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Pd 催化环丙烯酮通过连续 C-C 键激活和烯丙基化的三组分偶联


开发了一种新型的钯催化三组分多米诺反应，用于立体选择性合成高功能化烯丙基肉桂酸酯。在该方案中，C-C 键激活和分子间烯丙基取代的顺序过程组织良好。这种转变的关键是原位产生的环丙烯酮水解产物，它引发了与乙烯基碳酸亚乙酯的新反应。研究了反应机理，证明了该过程具有高立体选择性和优异的原子经济性。