Maintaining high affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a Phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12-months, suggesting poor maintenance of high affinity antibodies.

中文翻译：

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人类接种恶性疟原虫裂殖子候选疫苗后，抗体亲和力随着时间的推移而下降

疫苗接种后保持高亲和力抗体可能对于持久的疟疾免疫力很重要，但缺乏有关亲和力的诱导和动力学的数据。在一期疟疾疫苗试验中，第二次疫苗接种后抗体亲和力增加，但在 12 个月内大幅下降，表明高亲和力抗体的维持不良。