Gestational and Postpartum Exposure to PM2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study,Environmental Science & Technology

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Gestational and Postpartum Exposure to PM2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2024-05-10 , DOI: 10.1021/acs.est.4c03087
Yujing Chen _{1,

2} , Yuxuan Wang ₃ , Qian Chen ₄ , Ming Kei Chung _{2,

5,

6} , Yu Liu ₁ , Minyan Lan ₁ , Yanhong Wei ₇ , Lizi Lin ₈ , Li Cai ₁

Affiliation

Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China
The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, 999077, China
Global Health Research Center, Duke Kunshan University, Kunshan 215316, Jiangsu, China
Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong, China
Institute of Environment, Energy and Sustainability, The Chinese University of Hong Kong, Hong Kong 999077, China
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080 Guangdong, China
Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China

Pregnant women are physiologically prone to glucose intolerance, while the puerperium represents a critical phase for recovery. However, how air pollution disrupts glucose homeostasis during the gestational and early postpartum periods remains unclear. This prospective cohort study conducted an oral glucose tolerance test and measured the insulin levels of 834 pregnant women in Guangzhou, with a follow-up for 443 puerperae at 6–8 weeks postpartum. Residential PM_2.5 and five chemical components were estimated by an established spatiotemporal model. The adjusted linear model showed that an IQR increase in gestational PM_2.5 exposure was associated with an increase of 0.17 mmol/L (95% CI: 0.06, 0.28) in fasting plasma glucose (FPG) and 0.24 (95% CI: 0.05, 0.42) in the insulin resistance index. Postpartum PM_2.5 exposure was linked to a 0.17 mmol/L (95% CI: 0.05, 0.28) elevation in FPG per IQR, with a strengthened association found in women with gestational diabetes (P_interaction = 0.003). In the quantile-based g-computation model, NO₃^– consistently contributed to the combined effect of PM_2.5 components on gestational and postpartum FPG. This study was the first to suggest that PM_2.5 components were associated with exacerbated gestational insulin resistance and elevated postpartum FPG. Targeted interventions reducing the emissions of toxic PM_2.5 components are essential to improving maternal glucose metabolism.

更新日期：2024-05-10

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