Cohesive and interfacial adhesion energies are difficult to balance to obtain reversible adhesives with both high mechanical strength and high adhesion strength, although various methods have been extensively investigated. Here, a biocompatible citric acid/L-(−)-carnitine (CAC)-based ionic liquid was developed as a solvent to prepare tough and high adhesion strength ionogels for reversible engineered and biological adhesives. The prepared ionogels exhibited good mechanical properties, including tensile strength (14.4 MPa), Young’s modulus (48.1 MPa), toughness (115.2 MJ m^–3), and high adhesion strength on the glass substrate (24.4 MPa). Furthermore, the ionogels can form mechanically matched tough adhesion at the interface of wet biological tissues (interfacial toughness about 191 J m^–2) and can be detached by saline solution on demand, thus extending potential applications in various clinical scenarios such as wound adhesion and nondestructive transfer of organs.

中文翻译：

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具有可逆超分子粘附力的生物相容性坚韧离子凝胶


尽管已经广泛研究了各种方法，但很难平衡内聚能和界面粘合能以获得具有高机械强度和高粘合强度的可逆粘合剂。在此，开发了一种生物相容性柠檬酸/L-(−)-肉碱（CAC）基离子液体作为溶剂，以制备用于可逆工程粘合剂和生物粘合剂的坚韧且高粘合强度的离子凝胶。制备的离子凝胶表现出良好的机械性能，包括拉伸强度（14.4 MPa）、杨氏模量（48.1 MPa）、韧性（115.2 MJ m ^–3 ）和对玻璃基板的高粘附强度（24.4 MPa）。此外，离子凝胶可以在湿生物组织的界面上形成机械匹配的坚韧粘附（界面韧性约为191 J m ^–2 ），并且可以根据需要通过盐溶液剥离，从而扩展了在各种临床场景中的潜在应用如伤口粘连、器官无损转移等。