The relationship of ozone (O), particularly the long-term exposure, with impacting metabolic homeostasis in population was understudied and under-recognised. Here, we used data from ChinaHEART, a nationwide, population-based cohort study, combined with O and PM concentration data with high spatiotemporal resolution, to explore the independent association of exposure to O with the prevalence of insulin resistance (IR). Among the 271 540 participants included, the crude prevalence of IR was 39.1%, while the age and sex standardized prevalence stood at 33.0%. Higher IR prevalence was observed with each increase of 10.0 μg/m in long-term O exposure, yielding adjusted odds ratios (OR) of 1.084 (95% CI: 1.079–1.089) in the one-pollutant model and 1.073 (95% CI: 1.067–1.079) in the two-pollutant model. Notably, a significant additive interaction between O and PM on the prevalence of IR was observed ( for additive interaction < 0.001). Our main findings remained consistent and robust in the sensitivity analyses. Our study suggests long-term exposure to O was independently and positively associated with prevalence of IR. It emphasized the benefits of policy interventions to reduce O and PM exposure jointly, which could ultimately alleviate the health and economic burden related to DM.

中文翻译：

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胰岛素抵抗及其与长期暴露于臭氧的关系：基于全国人口队列的数据


臭氧（O），特别是长期暴露，与影响人群代谢稳态的关系尚未得到充分研究和认识。在这里，我们使用来自全国性人群队列研究 ChinaHEART 的数据，结合高时空分辨率的 O2 和 PM 浓度数据，探讨 O2 暴露与胰岛素抵抗 (IR) 患病率的独立关联。在纳入的 271 540 名参与者中，IR 粗患病率为 39.1%，而年龄和性别标准化患病率为 33.0%。长期 O 暴露每增加 10.0 μg/m，就会观察到较高的 IR 患病率，在单一污染物模型中，调整后的比值比 (OR) 为 1.084（95% CI：1.079–1.089），在单一污染物模型中，调整后的比值比 (OR) 为 1.073（95% CI） ：1.067–1.079）在两种污染物模型中。值得注意的是，观察到 O 和 PM 之间对 IR 患病率存在​​显着的加性相互作用（加性相互作用 < 0.001）。我们的主要发现在敏感性分析中保持一致和稳健。我们的研究表明，长期接触 O 与 IR 患病率呈独立正相关。它强调了政策干预措施共同减少 O 和 PM 暴露的好处，这最终可以减轻与 DM 相关的健康和经济负担。