In this study, we introduce a practical methodology for the synthesis of PET probes by seamlessly combining flow chemistry with photoredox radiofluorination. The clinical PET tracer 6-[¹⁸F]FDOPA was smoothly prepared in a 24.3% non-decay-corrected yield with over 99.0% radiochemical purity (RCP) and enantiomeric excess (ee), notably by a simple cartridge-based purification. The flow chemistry-enhanced photolabeling method supplies an efficient and versatile solution for the synthesis of 6-[¹⁸F]FDOPA and for more PET tracer development.

中文翻译：

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通过流动化学增强光氧化还原放射性氟化法制造 6-[18F]氟-L-DOPA


在这项研究中，我们介绍了一种通过将流动化学与光氧化还原放射性氟化无缝结合来合成 PET 探针的实用方法。临床 PET 示踪剂 6-[ ¹⁸ F]FDOPA 顺利制备，非衰变校正产率为 24.3%，放射化学纯度 (RCP) 和对映体过量 (ee) 超过 99.0%，特别是通过简单的方法基于滤筒的纯化。流式化学增强光标记方法为 6-[ ¹⁸ F]FDOPA 的合成和更多 PET 示踪剂的开发提供了高效且通用的解决方案。