Heterosis boosts crop yield; however, harnessing additional progressive heterosis in polyploids is challenging for breeders. We bioengineered a ‘mitosis instead of meiosis’ (MiMe) system that generates unreduced, clonal gametes in three hybrid tomato genotypes and used it to establish polyploid genome design. Through the hybridization of MiMe hybrids, we generated ‘4-haplotype’ plants that encompassed the complete genetics of their four inbred grandparents, providing a blueprint for exploiting polyploidy in crops.

中文翻译：

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利用杂交作物中的克隆配子来设计多倍体基因组

杂种优势提高作物产量；然而，利用多倍体中额外的渐进杂种优势对于育种者来说是一个挑战。我们通过生物工程设计了一种“有丝分裂而不是减数分裂”（MiMe）系统，该系统在三种杂交番茄基因型中产生未还原的克隆配子，并用它来建立多倍体基因组设计。通过MiMe杂种的杂交，我们生成了“4 单倍型”植物，包含其四个近交祖本的完整遗传，为利用作物的多倍体提供了蓝图。