Confining luminophores into modified hydrophilic matrices or polymers is a straightforward and widely used approach for afterglow bioimaging. However, the afterglow quantum yield and lifetime of the related material remain unsatisfactory, severely limiting the using effect especially for deep-tissue time-resolved imaging. This fact largely stems from the dilemma between material biocompatibility and the quenching effect of water environment. Herein an in situ metathesis promoted doping strategy is presented, namely, mixing ≈10⁻³ weight ratio of organic-emitter multicarboxylates with inorganic salt reactants, followed by metathesis reactions to prepare a series of hydrophilic but water-insoluble organic–inorganic doping afterglow materials. This strategy leads to the formation of edible long-afterglow photoluminescent materials with superior biocompatibility and excellent bioimaging effect. The phosphorescence quantum yield of the materials can reach dozens of percent (the highest case: 66.24%), together with the photoluminescent lifetime lasting for coupes of seconds. Specifically, a long-afterglow barium meal formed by coronene salt emitter and BaSO₄ matrix is applied into animal experiments by gavage, and bright stomach afterglow imaging is observed by instruments or mobile phone after ceasing the photoexcitation with deep tissue penetration. This strategy allows a flexible dosage of the materials during bioimaging, facilitating the development of real-time probing and theranostic technology.

中文翻译：

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用于生物成像的可食用长余辉光致发光材料


将发光体限制在改性亲水基质或聚合物中是一种简单且广泛使用的余辉生物成像方法。然而，相关材料的余辉量子产率和寿命仍不理想，严重限制了其尤其是深层组织时间分辨成像的使用效果。这一事实很大程度上源于材料生物相容性与水环境猝灭效应之间的困境。本文提出了一种原位复分解促进掺杂策略，即将约 10 ⁻³ 重量比的有机发射体多羧酸盐与无机盐反应物混合，然后进行复分解反应，制备一系列亲水但不溶于水的有机化合物。 ——无机掺杂余辉材料。该策略导致形成具有优异生物相容性和优异生物成像效果的可食用长余辉光致发光材料。该材料的磷光量子产率可达百分之几十（最高可达66.24%），光致发光寿命可达数秒。具体是将晕苯盐发射体与BaSO ₄ 基质形成的长余辉钡粉灌胃应用于动物实验，停止深部组织光激发后，通过仪器或手机观察明亮的胃部余辉成像。渗透。这种策略允许在生物成像过程中灵活地使用材料剂量，促进实时探测和治疗诊断技术的发展。