An enantioselective Pd-catalyzed intramolecular desymmetrizing cycloisomerization of N-(cyclopent-3-en-1-yl)propiolamides has been developed by employing a new chiral phosphoramidite ligand. A series of structurally unique bridged azabicycles are achieved in moderate to excellent yields with good E/Z selectivity and high enantioselectivity. Synthetic transformations are conducted to demonstrate the practical utility of this reaction.

中文翻译：

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Pd 催化炔系环戊烯的对映选择性去对称 1,7-烯炔环异构化


通过采用新的手性亚磷酰胺配体，开发了 N-(环戊-3-en-1-基)丙酰胺的对映选择性 Pd 催化分子内去对称环异构化。一系列结构独特的桥联氮杂二环化合物以中等至优异的产率获得，并具有良好的 E/Z 选择性和高对映选择性。进行合成转化以证明该反应的实际用途。