Dialkylchlorophosphines are among the most versatile building blocks for tertiary phosphine ligands, but their synthesis relies on the nucleophilic substitution of PCl₃, leaving substituents that require P–H precursors largely inaccessible. The primary phosphine reagent iPr₂NPH₂·BH₃ can serve as a doubly protected PH₂Cl proxy, enabling the synthesis of bis(bicyclo[1.1.1]pentyl)chlorophosphine (Bcp₂PCl) for the first time. Bcp₂PCl serves as a general reagent for the preparation of a family of bis(bicyclo[1.1.1]pentyl) alkyl- and arylphosphines, including new members of privileged phosphine ligand scaffolds.

中文翻译：

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双(双环[1.1.1]戊基)氯膦作为制备双(双环[1.1.1]戊基)膦的前体

二烷基氯膦是叔膦配体最通用的构建单元之一，但其合成依赖于 PCl ₃的亲核取代，使得需要 P-H 前体的取代基基本上难以接近。伯膦试剂iPr ₂ NPH ₂ ·BH ₃可作为双重保护的PH ₂ Cl代理，首次实现了双(双环[1.1.1]戊基)氯膦(Bcp ₂ PCl)的合成。 Bcp ₂ PCl 用作制备双（双环[1.1.1]戊基）烷基膦和芳基膦家族的通用试剂，包括特权膦配体支架的新成员。