A copper-catalyzed [3 + 2] annulation of O-acyl oximes with 4-sulfonamidophenols is developed. The advantage of this method lies in the concurrent double activation of two substrates to form nucleophilic enamines and electrophilic quinone monoimines. The substituent on the α-carbon of O-acyl oxime determines two different reaction pathways, thereby leading to the selective generation of 5-sulfonamidoindoles and 2-amido-5-sulfonamidobenzofuran-3(2H)-ones.

中文翻译：

---

铜催化 O-酰基肟与 4-磺酰胺基苯酚的 [3 + 2] 环化反应合成 5-磺酰胺基吲哚和 2-酰胺基-5-磺酰胺基苯并呋喃-3(2H)-酮


开发了铜催化的 O-酰基肟与 4-磺酰胺苯酚的 [3 + 2] 成环反应。该方法的优点在于同时双重活化两种底物，形成亲核烯胺和亲电醌单亚胺。 O-酰基肟的α-碳上的取代基决定了两种不同的反应途径，从而导致5-磺酰胺吲哚和2-酰胺基-5-磺酰胺苯并呋喃-3(2H)-酮的选择性生成。