ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes,The Journal of Organic Chemistry

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ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2024-05-13 , DOI: 10.1021/acs.joc.4c00491
Xuemei Wei _{1,

2} , Tao Cai _{1,

2} , Zhebing Zhang ₁ , Yanjuan Luo _{1,

2} , Tianbo Shang _{1,

2} , Hualiang Shen _{1,

2} , Huiting Xu _{1,

2} , Lemao Yu ₁ , Xiang Luo ₁ , Guoqi Yu ₂ , Runpu Shen _{1,

2}

Affiliation

A straightforward methodology for the assembly of polysubstituted naphthalenes from ortho-alkynyl benzyl alcohols, enabled by using catalytic amounts of Tf₂O, has been developed. This transformation not only features transition-metal free and without using other bases and additives but also provides a new synthetic application for ortho-alkynyl benzyl alcohols, i.e., as C6 synthons for the construction of PAHs.

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