There is an urgent need to develop safer and more effective modalities for the treatment of a wide range of pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout the years, selenium (Se) has attracted a great deal of attention due to its important role in human health. Besides, a growing body of work has unveiled that the inclusion of Se motifs into a great number of molecules is a promising strategy for obtaining novel therapeutic agents. In the current Perspective, we have gathered the most recent literature related to the incorporation of different Se moieties into the scaffolds of a wide range of known drugs and their feasible pharmaceutical applications. In addition, we highlight different representative examples as well as provide our perspective on Se drugs and the possible future directions, promises, opportunities, and challenges of this ground-breaking area of research.

中文翻译：

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小分子药物的硒化：董事会的新成员


由于耐药率不断增加、不良副作用、临床结果不佳等，迫切需要开发更安全、更有效的方法来治疗多种疾病。多年来，硒（Se）吸引了人们的关注。因其对人类健康的重要作用而受到广泛关注。此外，越来越多的工作表明，将 Se 基序纳入大量分子中是获得新型治疗剂的一种有前途的策略。在本期《展望》中，我们收集了有关将不同 Se 部分纳入多种已知药物的支架及其可行的药物应用的最新文献。此外，我们还重点介绍了不同的代表性实例，并提供了我们对硒药物的看法以及这一突破性研究领域未来可能的方向、承诺、机遇和挑战。