Over the past decade, significant progress has been made in the direct C–H acylation of naphthalenes, occurring at the α or β-positions to yield valuable ketones through Friedel–Crafts acylation or transition-metal-catalysed carbonylative coupling reactions. Nevertheless, highly regioselective acylation of naphthalenes remains a formidable challenge. Herein, we developed a nickel-catalysed reductive ring-opening reaction of 7-oxabenzonorbornadienes with acyl chlorides as the electrophilic coupling partner, providing a new method for the exclusive preparation of β-acyl naphthalenes.

中文翻译：

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还原条件下镍催化高区域选择性合成β-酰基萘

在过去的十年中，在萘的直接C-H酰化方面取得了重大进展，发生在α或β位，通过弗里德尔-克来福特酰化或过渡金属催化的羰基化偶联反应产生有价值的酮。然而，萘的高度区域选择性酰化仍然是一个艰巨的挑战。在此，我们开发了镍催化的7-氧苯并降冰片二烯与酰氯作为亲电偶合体的还原开环反应，为β-酰基萘的独家制备提供了新方法。