An unprecedented base-controlled selective skeletal rearrangement reaction of hexahydro-4H-indol-4-ones has been developed. In this protocol, highly functionalized dihydroxy-4H-cyclopenta[b]pyridin-4-ones and 8-alkenyl oxepane-2,6-diones were prepared with a broad substrate scope and high chemoselectivity in moderate to excellent yields selectively by modulating LiOH and Et₃N. In addition, the newly formed 8-alkenyl oxepane-2,6-dione scaffolds could be easily further derivatized to 5-(pyrrol-2-yl)dihydrofuran-2(3H)-ones through a rare intramolecular rearrangement reaction.

中文翻译：

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六氢-4H-吲哚-4-酮的可切换骨架重排：二羟基-4H-环戊[b]吡啶-4-酮和8-烯基氧杂环庚烷-2,6-二酮的不同合成


开发了一种前所未有的六氢-4H-吲哚-4-酮的碱基控制选择性骨架重排反应。在该方案中，通过调节 LiOH 和Et ₃ N。此外，新形成的8-烯基氧杂环庚烷-2,6-二酮支架可以很容易地进一步衍生化为5-(吡咯-2-基)二氢呋喃-2(3H)-酮通过罕见的分子内重排反应。