A novel three-component cyclization carbonylation reaction of iodoarene-tethered propargyl ethers with amine and CO is reported. This palladium-catalyzed cascade reaction undergoes a sequence of oxidative addition, unsaturated bond migration, carbonyl insertion, and nucleophilic attack to deliver the benzofuran skeleton. Both aromatic amines and aliphatic amines could proceed smoothly in this transformation under one atm of CO.

中文翻译：

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钯催化三组分级联羰基化反应构建苯并呋喃衍生物

报道了碘芳烃束缚的炔丙基醚与胺和 CO 的新型三组分环化羰基化反应。这种钯催化的级联反应经历一系列氧化加成、不饱和键迁移、羰基插入和亲核攻击，以产生苯并呋喃骨架。在一个大气压的CO下，芳香胺和脂肪胺都可以顺利进行这一转化。