Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity.

中文翻译：

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AS03ation 的免疫力：天然佐剂

人类对疫苗接种的反应并不相同。为了调查原因，Mulè 等人。开发了一个多模式框架，发现未经佐剂的流感疫苗接种后的高反应者以自然佐剂状态存在，模仿 AS03 佐剂疫苗接种后的先天免疫表型。这凸显了区分高抗体反应者的生物因素，以及佐剂如何增强先天免疫信号以改善体液免疫。