Electrochemical (EC) analysis has emerged as a high‐sensitivity, reliable, cost‐effective, and rapidly evolving technique that has garnered significant attention across diverse domains. Furthermore, EC‐based techniques hold great potential for miniaturization and integration. The integration of EC techniques with diverse mode/signal (such as light, magnetic, and thermal signals, etc.) provides unique opportunities for biosensors to acquire more information through a single sensing platform. By coupling multiple signals or processing them logically, the detection accuracy can be further improved, and the probability of false positives or negatives can be minimized. In this review, a thorough analysis of multi‐ mode/signal sensors in the field of EC sensing is conducted, along with their integration with various sensing techniques (e.g., fluorescence, photothermal, colorimetry, microfluidic, etc.). The aim is to delve into the latest advances, potential applications, as well as challenges in multi‐mode/signal biosensors, where the utilization of multiple sensing modalities helps enhance accuracy, sensitivity, and selectivity. This review provides new insight into the synergistic effects of integrating EC sensing with other techniques, aiming to shed light on the near‐future developments in EC‐integrated multi‐mode/signal biosensors.

中文翻译：

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多模式/信号生物传感器：电化学集成传感技术

电化学 (EC) 分析已成为一种高灵敏度、可靠、经济高效且快速发展的技术，在不同领域引起了广泛关注。此外，基于 EC 的技术在小型化和集成方面具有巨大的潜力。 EC 技术与多种模式/信号（例如光、磁和热信号等）的集成为生物传感器通过单一传感平台获取更多信息提供了独特的机会。通过耦合多个信号或对它们进行逻辑处理，可以进一步提高检测精度，并将误报或漏报的概率降至最低。在这篇综述中，对 EC 传感领域的多模式/信号传感器及其与各种传感技术（例如荧光、光热、比色法、微流体等）的集成进行了全面分析。目的是深入研究多模式/信号生物传感器的最新进展、潜在应用以及挑战，其中多种传感模式的利用有助于提高准确性、灵敏度和选择性。本综述对 EC 传感与其他技术集成的协同效应提供了新的见解，旨在揭示 EC 集成多模式/信号生物传感器的近期发展。