Tissue vascularization plays a critical role in the regeneration and repair of damaged tissues. However, in certain instances of tissue injury, the pace and effectiveness of vascularization can be limited. Innovative strategies leveraging magnetic fields and magnetic nanoparticles (MNPs) are devised to enhance the efficacy of tissue vascularization. This review explores the potential of magnetic field‐assisted strategies in augmenting tissue vascularization and repair. Direct application of static or dynamic magnetic fields, alone or in combination with MNPs, offers a means to modulate cellular behaviors and gene expression, thereby promoting angiogenesis and tissue regeneration. Techniques such as cell labeling, gene delivery using MNPs, and magnetic targeting have shown promise in efficiently repairing various ischemic tissue injuries by enhancing tissue vascularization. These strategies have broad applications in bone and skin tissue regeneration, limb ischemia treatment, myocardial injury treatment, and diabetic wound therapy. By summarizing recent advancements in magnetically controlled strategies, this review aims to shed light on their future prospects in tissue regeneration and clinical treatment.

中文翻译：

---

增强组织血管化的磁控策略

组织血管化在受损组织的再生和修复中起着至关重要的作用。然而，在某些组织损伤的情况下，血管化的速度和有效性可能受到限制。利用磁场和磁性纳米粒子（MNP）的创新策略旨在增强组织血管化的功效。本综述探讨了磁场辅助策略在增强组织血管化和修复方面的潜力。直接应用静态或动态磁场，单独或与 MNP 结合，提供了一种调节细胞行为和基因表达的方法，从而促进血管生成和组织再生。细胞标记、使用 MNP 进行基因传递和磁靶向等技术已显示出通过增强组织血管化来有效修复各种缺血性组织损伤的前景。这些策略在骨和皮肤组织再生、肢体缺血治疗、心肌损伤治疗和糖尿病伤口治疗方面具有广泛的应用。通过总结磁控策略的最新进展，本综述旨在揭示其在组织再生和临床治疗方面的未来前景。