Nanostructuration of dynamic helical polymers such as poly(phenylacetylene)s (PPAs) depends on the secondary structure adopted by the polymer and the functional group used to connect the chiral pendant to the PPA backbone. Thus, while PPAs with dynamic and flexible scaffolds (para‐ and meta‐substituted, ω1< 165º) generate by nanoprecipitation low polydisperse nanospheres with controllable size at different acetone/water mixtures, those with a quasi‐static behavior and the presence of an extended, almost planar structure (ortho‐substituted, ω1> 165º), aggregate into a mixture of spherical and oval nanostructures whose size is not controlled. Photostability studies show that poly(phenylacetylene) particles are more stable to light irradiation than when dissolved macromolecularly. Moreover, the photostability of the particle depends on the secondary structure of the PPA and its screw sense excess. This fact, in combination with the encapsulation ability of these polymer particles, allows the creation of light stimuli‐responsive nanocarriers, whose cargo can be delivered by light irradiation.

中文翻译：

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在没有表面活性剂的情况下通过螺旋聚苯乙炔纳米沉淀获得的手性纳米球的尺寸控制

动态螺旋聚合物（例如聚苯乙炔 (PPA)）的纳米结构取决于聚合物采用的二级结构以及用于将手性侧链连接到 PPA 主链的官能团。因此，虽然具有动态和柔性支架（对位和间位取代，ω1<165°）的 PPA 通过纳米沉淀生成在不同丙酮/水混合物中具有可控尺寸的低多分散纳米球，但那些具有准静态行为和存在扩展的纳米球，几乎平面结构（邻位取代，ω1> 165°），聚集成球形和椭圆形纳米结构的混合物，其尺寸不受控制。光稳定性研究表明，聚苯乙炔颗粒对光照射比溶解大分子时更稳定。此外，颗粒的光稳定性取决于PPA的二级结构及其螺旋感过量。这一事实与这些聚合物颗粒的封装能力相结合，可以创建光刺激响应纳米载体，其货物可以通过光照射来输送。