BackgroundThe aim of this study was to investigate the association between peri‐implant diseases and systemic inflammation assessed by serum C‐reactive protein (CRP) levels in a sample of patients with hypertension.MethodsA total of 151 participants with hypertension were included in a cross‐sectional study. The population was divided into six groups according to their peri‐implant and periodontal status (healthy controls, mucositis, peri‐implantitis, periodontitis, periodontitis and mucositis, periodontitis, and peri‐implantitis). Linear, logistic regression, and correlation analyses were performed.ResultsCRP levels were statistically significantly higher in participants with periodontitis alone (median 3.2 mg/L, interquartile range [IQR] 1.8, p = 0.012), combined with mucositis (3.10 mg/L, IQR 2.35, p < 0.001) or peri‐implantitis (2.7 mg/L, IQR 2.53, p = 0.002) when compared to the healthy controls (1 mg/L, IQR 1.2). This association was independent of age, sex, smoking status, and adiposity differences. Participants with periodontitis with and without peri‐implant diseases had the greatest odds of exhibiting CRP > 3 mg/L (odds ratio = 7.3, 95% confidence interval 1.6–33.9).ConclusionsPeri‐implant diseases are associated with systemic inflammation, but the nature of the association should be further investigated.

中文翻译：

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种植体周围疾病与全身炎症：高血压患者横断面调查的初步分析

背景本研究的目的是调查高血压患者样本中通过血清 C 反应蛋白 (CRP) 水平评估的种植体周围疾病与全身炎症之间的关联。方法共有 151 名高血压患者参与了一项交叉研究。截面研究。根据种植体周围和牙周状况将人群分为六组（健康对照、粘膜炎、种植体周围炎、牙周炎、牙周炎和粘膜炎、牙周炎和种植体周围炎）。进行线性、逻辑回归和相关分析。结果仅患有牙周炎的参与者的 CRP 水平在统计学上显着较高（中位数 3.2 mg/L，四分位距 [IQR] 1.8，p= 0.012），合并粘膜炎（3.10 mg/L，IQR 2.35，p< 0.001）或种植体周围炎（2.7 mg/L，IQR 2.53，p= 0.002）与健康对照（1 mg/L，IQR 1.2）相比。这种关联与年龄、性别、吸烟状况和肥胖差异无关。患有或不患有种植体周围疾病的牙周炎参与者表现出 CRP > 3 mg/L 的可能性最大（比值比 = 7.3，95% 置信区间 1.6–33.9）。 结论 种植体周围疾病与全身炎症相关，但其性质协会的情况还需进一步调查。