Bacterial infection has become a long-term concern that seriously threatens human health. However, the application of conventional antibacterial materials in antibacterial treatment and infection prevention has been severely hindered due to their limitations such as complex synthesis, high cost, and high cytotoxicity. Therefore, developing a facile and cost-effective route to prepare high-performance antibacterial materials is of urgent need and significant importance. In this work, we for the first time reported that oxygen-sulfur terminal bonds possess excellent antibacterial properties, and the oxygen-sulfur terminal polymer (OSTP) can effectively kill bacteria when contacting and interacting with the bacteria. A universal and simple initiator strategy has been developed to fabricate OSTPs through a facile solution polymerization process. this approach, the PEGDA-APS OSTPs exhibited superfast and superior antibacterial properties against both Gram-positive and Gram-negative bacteria while maintaining good hemocompatibility and cytocompatibility, outperforming many common antibacterial agents that usually require several hours of bacterial extinction. Moreover, it was demonstrated that OSTPs exhibited excellent antibacterial activity in a wide range of application situations, including textile, medicine, washing, food, and coating, as well as antibacterial hydrogels.

中文翻译：

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来自简单引发剂策略的抗菌氧硫末端聚合物


细菌感染已成为严重威胁人类健康的长期问题。然而，常规抗菌材料由于其合成复杂、成本高、细胞毒性高等局限性，在抗菌治疗和感染预防中的应用受到严重阻碍。因此，开发一种简便且经济有效的途径来制备高性能抗菌材料是迫切需要且具有重要意义的。在这项工作中，我们首次报道了氧硫末端键具有优异的抗菌性能，氧硫末端聚合物（OSTP）在与细菌接触和相互作用时可以有效杀死细菌。已经开发出一种通用且简单的引发剂策略，通过简单的溶液聚合工艺来制造OSTP。通过这种方法，PEGDA-APS OSTP 对革兰氏阳性菌和革兰氏阴性菌表现出超快速和卓越的抗菌特性，同时保持良好的血液相容性和细胞相容性，优于许多通常需要数小时细菌灭绝的常见抗菌剂。此外，研究表明OSTP在纺织、医药、洗涤、食品、涂料以及抗菌水凝胶等广泛应用领域表现出优异的抗菌活性。