Sucrose-6-acetate (S-6-A) is an important intermediate in the industrial production process of sucralose. In this work, the synthesis and reaction kinetics for both the high-temperature and low-temperature processes of sucrose acylation to produce S-6-A via the dibutyltin oxide method were investigated. The influences of the molar ratios of both dibutyltin oxide (DBTO)/sucrose and acetic anhydride/sucrose, reaction time, and temperature on the yield of S-6-A were evaluated. Based on the reaction mechanism of the high-temperature process and the solubility characteristic of DBTO, the first-order pseudohomogeneous kinetic model was proposed, which fitted experimental data well in the temperature range of 360.15 to 370.65 K. In addition, the second-order pseudohomogeneous kinetic model was established for the low-temperature process, and the model fitting was in good agreement with experimental data in the temperature range of 274.15 to 296.15 K. The results indicate that the early stage cooling and reduction of reaction time can significantly enhance the yield of S-6-A in the low-temperature process. Hopefully, the kinetic models developed in this work can provide valuable insights into the process optimization of the acylation reaction, the design of the reactors, and the continuous process.

中文翻译：

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二丁基氧化锡法蔗糖酰化为 6-乙酸蔗糖的工艺优化和动力学建模


6-乙酸蔗糖酯（S-6-A）是三氯蔗糖工业生产过程中的重要中间体。在这项工作中，研究了通过二丁基氧化锡法蔗糖酰化生产S-6-A的高温和低温过程的合成和反应动力学。评价了二丁基氧化锡(DBTO)/蔗糖和乙酸酐/蔗糖的摩尔比、反应时间和温度对S-6-A产率的影响。基于高温过程的反应机理和DBTO的溶解度特性，提出了一阶拟均相动力学模型，该模型在360.15~370.65 K温度范围内与实验数据吻合良好。建立了低温过程的拟均相动力学模型，模型拟合与274.15~296.15 K温度范围内的实验数据吻合较好。结果表明，早期冷却和缩短反应时间可以显着提高低温过程的反应速度。低温过程中S-6-A的产率。希望这项工作中开发的动力学模型能够为酰化反应的工艺优化、反应器的设计和连续过程提供有价值的见解。