Compared with traditional “lock–key mode” biosensors, a sensor array consists of a series of sensing elements based on intermolecular interactions (typically hydrogen bonds, van der Waals forces, and electrostatic interactions). At the same time, sensor arrays also have the advantages of fast response, high sensitivity, low energy consumption, low cost, rich output signals, and imageability, which have attracted widespread attention from researchers. Nanozymes are nanomaterials which own enzyme-like properties. Because of the adjustable activity, high stability, and cost effectiveness of nanozymes, they are potential candidates for construction of sensor arrays to output different signals from analytes through the chemoresponse of colorants, which solves the shortcomings of traditional sensors that they cannot support multiple detection and lack universality. Recently, a sensor array based on nanozymes as nonspecific recognition receptors has attracted much more attention from researchers and has been applied to precise recognition of proteins, bacteria, and heavy metals. In this perspective, attention is given to nanozymes and the regulation of their enzyme-like activity. Particularly, the building principles and methods for sensor arrays based on nanozymes are analyzed, and the applications are summarized. Finally, the approaches to overcome the challenges and perspectives are also presented and analyzed for facilitating further research and development of nanozyme sensor arrays. This perspective should be helpful for gaining insight into research ideas within the field of nanozyme sensor arrays.

中文翻译：

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纳米酶传感器阵列的构建及应用


与传统的“锁钥匙模式”生物传感器相比，传感器阵列由一系列基于分子间相互作用（通常是氢键、范德华力和静电相互作用）的传感元件组成。同时，传感器阵列还具有响应快、灵敏度高、能耗低、成本低、输出信号丰富、成像能力强等优点，受到了研究人员的广泛关注。纳米酶是具有类似酶特性的纳米材料。由于纳米酶活性可调、稳定性高、成本效益高，因此成为构建传感器阵列的潜在候选者，通过着色剂的化学反应输出分析物的不同信号，解决了传统传感器不能支持多种检测和检测的缺点。缺乏普遍性。近年来，基于纳米酶作为非特异性识别受体的传感器阵列引起了研究人员的广泛关注，并已应用于蛋白质、细菌和重金属的精确识别。从这个角度来看，人们关注纳米酶及其类酶活性的调节。特别分析了基于纳米酶的传感器阵列的构建原理和方法，并总结了其应用。最后，还提出并分析了克服挑战的方法和前景，以促进纳米酶传感器阵列的进一步研究和开发。这种观点应该有助于深入了解纳米酶传感器阵列领域的研究思想。