Ketogenic diets have attracted substantial interest in the treatment of chronic diseases, but there are health risks with long-term regimes. Despite the advancements in diagnostic and therapeutic methods in modern medicine, there is a huge gap in personalized health management of this dietary strategy. Hence, we present a wearable microneedle biosensor for real-time ketone and glucose monitoring. The microneedle array possesses excellent mechanical properties, allowing for consistent sampling of interstitial biomarkers while reducing the pain associated with skin puncture. Vertical graphene with outstanding electrical conductivity provides the resulting sensor with a high sensitivity of 234.18 μA mM^–1 cm^–2 and a low limit detection of 1.21 μM. When this fully integrated biosensor was used in human volunteers, it displayed an attractive analytical capability for tracking the dynamic metabolite levels. Moreover, the results of the on-body evaluation established a significant correlation with commercial blood measurements. Overall, this cost-effective and efficient sensing platform can accelerate the application of a ketogenic diet in personal nutrition and wellness management.

中文翻译：

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用于实时生酮饮食管理的可穿戴垂直石墨烯微针生物传感器


生酮饮食在慢性疾病的治疗中引起了极大的兴趣，但长期的饮食方式存在健康风险。尽管现代医学的诊断和治疗方法取得了进步，但这种饮食策略的个性化健康管理仍存在巨大差距。因此，我们提出了一种用于实时酮和葡萄糖监测的可穿戴微针生物传感器。微针阵列具有优异的机械性能，可以对间质生物标志物进行一致的采样，同时减少与皮肤穿刺相关的疼痛。具有出色导电性的垂直石墨烯使所得传感器具有234.18 μA mM ^–1 cm ^–2 的高灵敏度和1.21 μM的低检测限。当这种完全集成的生物传感器用于人类志愿者时，它在跟踪动态代谢物水平方面表现出了有吸引力的分析能力。此外，体内评估的结果与商业血液测量建立了显着的相关性。总体而言，这种经济高效的传感平台可以加速生酮饮食在个人营养和健康管理中的应用。