Examples of two metal centers working synergistically to catalyze challenging chemical transformations can be found throughout biological and synthetic systems. In each case, specific metal identities, ligand environments, and metal–metal distances are required. The structural precision needed to engineer a productive, surface-supported bimetallic active site represents an opportunity for metal–organic frameworks. In this perspective, we summarize the different ways binuclear metal active sites have been synthesized in metal–organic frameworks and applied in catalysis. Selected examples from the literature will be highlighted to illustrate both the diversity of synthetic approaches as well as the diversity of bimetallic structures.

中文翻译：

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金属有机框架中的双金属活性位点工程：挑战和机遇†


在整个生物和合成系统中都可以找到两个金属中心协同催化具有挑战性的化学转化的例子。在每种情况下，都需要特定的金属特性、配体环境和金属-金属距离。设计高效、表面支撑的双金属活性位点所需的结构精度为金属有机框架提供了机会。从这个角度来看，我们总结了在金属有机框架中合成双核金属活性位点并将其应用于催化的不同方式。将重点介绍文献中选定的例子，以说明合成方法的多样性以及双金属结构的多样性。