Nerve guidance conduits (NGCs) have been considered as promising treatment strategy and frontier trend for peripheral nerve regeneration; while their therapeutic outcomes are limited by the lack of controllable drug delivery and available physicochemical cues. Herein, we propose novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)‐triggered electrical stimulation (ES) and controllable drug release for repairing peripheral nerve injury. The inner layer of the NGCs was the barium titanate piezoelectric nanoparticles (BTNPs)‐doped polyvinylidene fluoride‐trifluoroethylene [BTNPs/P(VDF‐TrFE)] electrospinning nanofibers with improved piezoelectricity and aligned orientation. The outer side of the NGCs was the thermoresponsive poly(N‐isopropylacrylamide) (pNIPAM) hybrid hydrogel with bioactive drug encapsulation. Such NGCs could not only induce neuronal oriented extension and promote neurite outgrowth with US‐triggered wireless ES, but also realize the controllable nerve growth factor (NGF) release with the hydrogel shrinkage under US‐triggered heating. Thus, the NGC could positively accelerate the functional recovery and nerve axonal regeneration of rat models with long sciatic nerve defects. We believe that the proposed US‐responsive aligned piezoelectric nanofibers derived hydrogel NGCs will find important applications in clinic neural tissue engineering.This article is protected by copyright. All rights reserved

中文翻译：

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用于周围神经再生的超声响应对齐压电纳米纤维衍生水凝胶导管


神经引导导管（NGC）被认为是周围神经再生的有前景的治疗策略和前沿趋势；而它们的治疗效果因缺乏可控的药物输送和可用的理化线索而受到限制。在此，我们提出了新型对齐压电纳米纤维衍生的水凝胶NGC，具有超声（US）触发的电刺激（ES）和可控药物释放，用于修复周围神经损伤。 NGCs的内层是钛酸钡压电纳米颗粒（BTNPs）掺杂的聚偏二氟乙烯-三氟乙烯[BTNPs/P(VDF-TrFE)]静电纺丝纳米纤维，具有改善的压电性和定向排列。 NGC的外侧是具有生物活性药物封装的热响应性聚（N-异丙基丙烯酰胺）（pNIPAM）杂化水凝胶。这种NGC不仅可以通过超声触发的无线ES诱导神经元定向延伸并促进神经突生长，而且还可以通过超声触发加热下的水凝胶收缩来实现可控的神经生长因子（NGF）释放。因此，NGC可以积极加速坐骨神经长缺损模型大鼠的功能恢复和神经轴突再生。我们相信，所提出的美国响应对齐压电纳米纤维衍生的水凝胶 NGC 将在临床神经组织工程中找到重要的应用。本文受版权保护。版权所有