Abstract
Microfluidics has been applied in the preparation of monodisperse droplets and microcapsules due to its high encapsulation efficiency, its ability to create uniform particle sizes, and its capacity to control core–shell ratio and structure. To bring to the fore methodologies for the fabrication and application of monodisperse microcapsules using microfluidics, we present a review of the design, structure, materials, and surface modification techniques of various microfluidic chips. The review also covers fabrication methods, operating parameters and regulation methods of single and multiple monodisperse emulsion droplets fabricated from various microfluidic devices. Our findings show that particle size of monodisperse droplets depend mainly on microchannel characteristic size and flow rate, with particle size increasing with larger microchannel but decreasing with higher continuous phase flow rate. We additionally reviewed and compared various fabrication methods for monodisperse microcapsules, such as interfacial polymerization, free-radical polymerization, ionic cross-linking, and solvent evaporation. We further reviewed and examined the application of monodisperse microcapsules in biology applications, food engineering, composite materials development, and pharmaceutical industry. We found that high-throughput microfluidics for scale-up monodisperse microcapsule preparation towards uniform degradation and targeted release properties of monodisperse microcapsules would be key innovative direction for future applications.
Funding source: Taishan Scholars Foundation of Shandong Province
Award Identifier / Grant number: tsqn201812087
Funding source: Qilu University of Technology (Shandong Academy of Sciences)
Award Identifier / Grant number: Science, Education and Industry Integration Innovation Pilot Project (2022JBZ02-01)
Funding source: Department of Education of Shandong Province
Award Identifier / Grant number: Innovative Research Team of Advanced Energy Equipment
Award Identifier / Grant number: 2019KJB009
Award Identifier / Grant number: Innovative Research Team of High-Performance Integrated Device
Funding source: Jinan Scientific Research Leader Workshop Project
Award Identifier / Grant number: 2021GXRC083
Acknowledgements
We acknowledge the copyright permission from the journals for the graphics, images, and figures.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This work was supported by the Qing Chuang plan by Shandong Province Department of Education (Sub-Title 1: Innovative Research Team of Advanced Energy Equipment, Sub-Title 2: Innovative Research Team of High-Performance Integrated Device, no. 2019KJB009); Taishan Scholars Foundation of Shandong Province (no. tsqn201812087); Jinan Scientific Research Leader Studio (no. 2021GXRC083); Science, Education and Industry Integration Innovation Pilot Project from Qilu University of Technology (Shandong Academy of Sciences)(No.2022JBZ02-01).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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