By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multiple immune signalling pathways. Immunotherapy with mineralized bacteria suppressed various types of cancer in multiple animal models, eliciting both immune memory and abscopal antitumour effects.
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References
Zhou, S., Gravekamp, C., Bermudes, D. & Liu, K. Tumour-targeting bacteria engineered to fight cancer. Nat. Rev. Cancer 18, 727–743 (2018). A review article summarizing the potential benefits and challenges of cancer immunotherapy with live bacteria.
Demaria, O. et al. Harnessing innate immunity in cancer therapy. Nature 574, 45–56 (2019). A review article that presents the crucial role of innate immune responses in cancer immunotherapy.
O’Neill, L., Golenbock, D. & Bowie, A. The history of Toll-like receptors — redefining innate immunity. Nat. Rev. Immunol. 13, 453–460 (2013). A review article that presents the central role of TLRs in immunity.
Wang, C. et al. Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses. Immunity 48, 675–687 (2018). This paper reports that manganese can activate innate immunity via the cGAS–STING pathway.
Chen, Q. et al. Intelligent albumin–MnO2 nanoparticles as pH-/H2O2-responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy. Adv. Mater. 28, 7129–7136 (2016). This paper reports the preparation method of MnO2-encapsulated protein nanoparticles.
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This is a summary of: Wang, C. et al. Oncolytic mineralized bacteria as potent locally administered immunotherapeutics. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01191-w (2024).
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Mineralized bacteria as an immunotherapy agent against various cancer types. Nat. Biomed. Eng (2024). https://doi.org/10.1038/s41551-024-01192-9
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DOI: https://doi.org/10.1038/s41551-024-01192-9