Issue 43, 2024

Cold denaturation of DNA origami nanostructures

Abstract

The coupling of structural transitions to heat capacity changes leads to destabilization of macromolecules at both elevated and lowered temperatures. DNA origami not only exhibit this property but also provide a nanoscopic observable of cold denaturation processes by directing intramolecular strain to the most sensitive elements within their hierarchical architecture.

Graphical abstract: Cold denaturation of DNA origami nanostructures

Supplementary files

Article information

Article type
Communication
Submitted
08 Dec 2023
Accepted
09 Apr 2024
First published
22 Apr 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 5590-5593

Cold denaturation of DNA origami nanostructures

D. Dornbusch, M. Hanke, E. Tomm, C. Kielar, G. Grundmeier, A. Keller and K. Fahmy, Chem. Commun., 2024, 60, 5590 DOI: 10.1039/D3CC05985E

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