The coupling of structural transitions to heat capacity changes leads to destabilization of macromolecules at both elevated and lowered temperatures. DNA origami not only exhibit this property but also provide a nanoscopic observable of cold denaturation processes by directing intramolecular strain to the most sensitive elements within their hierarchical architecture.

中文翻译：

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DNA 折纸纳米结构的冷变性

结构转变与热容变化的耦合导致大分子在高温和低温下不稳定。 DNA折纸不仅表现出这种特性，而且还通过将分子内应变引导至其分层结构中最敏感的元素，提供冷变性过程的纳米级可观察。