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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-12 Piao Zhao, Lin Feng, Weidan Jiang, Pei Wu, Yang Liu, Hongmei Ren, Xiaowan Jin, Lu Zhang, Haifeng Mi, Xiaoqiu Zhou
Ochratoxin A (OTA), a globally abundant and extremely hazardous pollutant, is a significant source of contamination in aquafeeds and is responsible for severe food pollution. The developmental toxicity of OTA and the potential relieving strategy of natural products remain unclear. This study screened the substance curcumin (Cur), which had the best effect in alleviating OTA inhibition of myoblast proliferation
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Large-scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-11 Di Zhao, Ranran Liu, Xiaodong Tan, Huimin Kang, Jie Wang, Zheng Ma, Haiquan Zhao, Hai Xiang, Zhengfen Zhang, Hua Li, Guiping Zhao
Carcass traits are crucial indicators of meat production efficiency. However, the molecular regulatory mechanisms associated with these traits remain unclear. In this study, we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory mechanisms. Based on
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Proteo-transcriptomic profiles reveal key regulatory pathways and functions of LDHA in the ovulation of domestic chickens (Gallus gallus) J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-10 Ruixue Nie, Wenhui Zhang, Haoyu Tian, Junying Li, Yao Ling, Bo Zhang, Hao Zhang, Changxin Wu
In poultry, the smooth transition of follicles from the preovulatory-to-postovulatory phase impacts egg production in hens and can benefit the poultry industry. However, the regulatory mechanism underlying follicular ovulation in avians is a complex biological process that remains unclear. Critical biochemical events involved in ovulation in domestic chickens (Gallus gallus) were evaluated by transcriptomics
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Dietary glycine supplementation enhances syntheses of creatine and glutathione by tissues of hybrid striped bass (Morone saxatilis ♀ × Morone chrysops ♂) fed soybean meal-based diets J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-09 Wenliang He, Xinyu Li, Guoyao Wu
We recently reported that supplementing glycine to soybean meal-based diets is necessary for the optimum growth of 5- to 40-g (Phase-I) and 110- to 240-g (Phase-II) hybrid striped bass (HSB), as well as their intestinal health. Although glycine serves as an essential substrate for syntheses of creatine and glutathione (GSH) in mammals (e.g., pigs), little is known about these metabolic pathways or
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Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-08 Aakilah S. Hernandez, Gabriel A. Zayas, Eduardo E. Rodriguez, Kaitlyn M. Sarlo Davila, Fahad Rafiq, Andrea N. Nunez, Cristiane Gonçalves Titto, Raluca G. Mateescu
Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around $369 million being lost annually due to reduced performance. Heat stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production levels. Cattle utilize various physiological mechanisms such as sweating to regulate internal heat. Variation
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Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-07 Sai Zhang, Juan C. Marini, Vengai Mavangira, Andrew Claude, Julie Moore, Mahmoud A. Mohammad, Nathalie L. Trottier
The study objective was to test the hypothesis that low crude protein (CP) diet with crystalline amino acids (CAA) supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein breakdown. Eighteen lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets (10.80 MJ/kg net energy): control (CON; 19.24% CP) and reduced CP with
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Pangenome and multi-tissue gene atlas provide new insights into the domestication and highland adaptation of yaks J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-06 Daoliang Lan, Wei Fu, Wenhui Ji, Tserang-Donko Mipam, Xianrong Xiong, Shi Ying, Yan Xiong, Peng Sheng, Jiangping Ni, Lijun Bai, Tongling Shan, Xiangdong Kong, Jian Li
The genetic diversity of yak, a key domestic animal on the Qinghai-Tibetan Plateau (QTP), is a vital resource for domestication and breeding efforts. This study presents the first yak pangenome obtained through the de novo assembly of 16 yak genomes. We discovered 290 Mb of nonreference sequences and 504 new genes. Our pangenome-wide presence and absence variation (PAV) analysis revealed 5,120 PAV-related
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Investigation of the nutritional and functional roles of a combinational use of xylanase and β-glucanase on intestinal health and growth of nursery pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-05 Hyunjun Choi, Yesid Garavito Duarte, Guilherme A. M. Pasquali, Sung Woo Kim
Xylanase and β-glucanase combination (XG) hydrolyzes soluble non-starch polysaccharides that are anti-nutritional compounds. This study aimed to evaluate the effects of increasing levels of XG on intestinal health and growth performance of nursery pigs. Forty pigs (6.5 ± 0.4 kg) were assigned to 5 dietary treatments and fed for 35 d in 3 phases (11, 9, and 15 d, respectively). Basal diets mainly included
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Effect of in ovo feeding of xylobiose and xylotriose on plasma immunoglobulin, cecal metabolites production, microbial ecology, and metabolic pathways in broiler chickens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-04 Razib Das, Pravin Mishra, Birendra Mishra, Rajesh Jha
Dietary supplementation of xylooligosaccharides (XOS) has been found to influence gut health by manipulating cecal microbiota and producing microbe-origin metabolites. But no study investigated and compared the effect of in ovo feeding of xylobiose (XOS2) and xylotriose (XOS3) in chickens. This study investigated the effect of in ovo feeding of these XOS compounds on post-hatch gut health parameters
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The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-03 Heng Yang, Xiangqi Fan, Xiangbing Mao, Bing Yu, Jun He, Hui Yan, Jianping Wang
Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity
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Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-02 Guangliang Gao, Rui Liu, Silu Hu, Mengnan He, Jiaman Zhang, Dengfeng Gao, Jing Li, Jiwei Hu, Jiwen Wang, Qigui Wang, Mingzhou Li, Long Jin
Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin
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The application of omics technologies for understanding tropical plants-based bioactive compounds in ruminants: a review J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-05-01 Metha Wanapat, Gamonmas Dagaew, Sukruthai Sommai, Maharach Matra, Chaichana Suriyapha, Rittikeard Prachumchai, Uswatun Muslykhah, Srisan Phupaboon
Finding out how diet impacts health and metabolism while concentrating on the functional qualities and bioactive components of food is the crucial scientific objective of nutritional research. The complex relationship between metabolism and nutrition could be investigated with cutting-edge "omics" and bioinformatics techniques. This review paper provides an overview of the use of omics technologies
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Correction: Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-24 Rosane Mazzarella, Karina Cañón-Beltrán, Yulia N. Cajas, Meriem Hamdi, Encina M. González, Juliano C. da Silveira, Claudia L. V. Leal, D. Rizos
Correction: J Animal Sci Biotechnol 15, 51 (2024) https://doi.org/10.1186/s40104-024-01008-5 Following publication of the original article [1], the authors reported that the last two sentences were mistakenly placed at the end of the Results section in the Abstract which should have been placed at the beginning of this section. The original Results section in the Abstract was: From the 20 differentially
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Dietary eubiotics of microbial muramidase and glycan improve intestinal villi, ileum microbiota composition and production trait of broiler J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-10 Sungbo Cho, Shanmugam Suresh Kumar, Santiago Ramirez, Rolando Valientes, In Ho Kim
Optimal gut health is important to maximize growth performance and feed efficiency in broiler chickens. A total of 1,365 one-day-old male Ross 308 broiler chickens were randomly divided into 5 treatments groups with 21 replicates, 13 birds per replicate. The present research investigated effects of microbial muramidase or a precision glycan alone or in combination on growth performance, apparent total
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Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-09 Qi Huang, Jiashuo Liu, Can Peng, Xuefeng Han, Zhiliang Tan
Hesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary epithelial cells (bMECs) exposed to oxidative stress have not been elucidated. In this study, we investigated the effects of hesperidin on H2O2-induced oxidative stress in bMECs and the underlying molecular mechanism. We found that hesperidin attenuated H2O2-induced cell
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Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-08 Wei He, Xinyu Liu, Ye Feng, Hongwei Ding, Haoyang Sun, Zhongyu Li, Baoming Shi
Cold stress has negative effects on the growth and health of mammals, and has become a factor restricting livestock development at high latitudes and on plateaus. The gut-liver axis is central to energy metabolism, and the mechanisms by which it regulates host energy metabolism at cold temperatures have rarely been illustrated. In this study, we evaluated the status of glycolipid metabolism and oxidative
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Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-07 Feifei Ding, Nannan Zhou, Yuan Luo, Tong Wang, Weijie Li, Fang Qiao, Zhenyu Du, Meiling Zhang
Intestinal barrier is a dynamic interface between the body and the ingested food components, however, dietary components or xenobiotics could compromise intestinal integrity, causing health risks to the host. Gossypol, a toxic component in cottonseed meal (CSM), caused intestinal injury in fish or other monogastric animals. It has been demonstrated that probiotics administration benefits the intestinal
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Endotoxin-induced alterations of adipose tissue function: a pathway to bovine metabolic stress J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-06 Miguel Chirivi, G. Andres Contreras
During the periparturient period, dairy cows exhibit negative energy balance due to limited appetite and increased energy requirements for lactogenesis. The delicate equilibrium between energy availability and expenditure puts cows in a state of metabolic stress characterized by excessive lipolysis in white adipose tissues (AT), increased production of reactive oxygen species, and immune cell dysfunction
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Pelleting and particle size reduction of corn increase net energy and digestibility of fiber, protein, and fat in corn-soybean meal diets fed to group-housed pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-05 Su A Lee, Diego A. Rodriguez, Chad B. Paulk, Hans H. Stein
Reduction of the particle size of corn increases energy digestibility and concentrations of digestible and metabolizable energy. Pelleting may also reduce particle size of grain, but it is not known if there are interactions between particle size reduction and pelleting. The objective of this experiment was to test the hypothesis that particle size reduction and pelleting, separately or in combination
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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-04 Rosane Mazzarella, Karina Cañón-Beltrán, Yulia N. Cajas, Meriem Hamdi, Encina M. González, Juliano C. da Silveira, Claudia L. V. Leal, D. Rizos
Extracellular vesicles (EVs) present in oviductal (OF) and uterine fluid (UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes (LMGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related
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Dietary sodium acetate and sodium butyrate improve high-carbohydrate diet utilization by regulating gut microbiota, liver lipid metabolism, oxidative stress, and inflammation in largemouth bass (Micropterus salmoides) J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-03 Qiao Liu, Liangshun Cheng, Maozhu Wang, Lianfeng Shen, Chengxian Zhang, Jin Mu, Yifan Hu, Yihui Yang, Kuo He, Haoxiao Yan, Liulan Zhao, Song Yang
Adequate level of carbohydrates in aquafeeds help to conserve protein and reduce cost. However, studies have indicated that high-carbohydrate (HC) diet disrupt the homeostasis of the gut–liver axis in largemouth bass, resulting in decreased intestinal acetate and butyrate level. Herein, we had concepted a set of feeding experiment to assess the effects of dietary sodium acetate (SA) and sodium butyrate
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Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-02 Giulia Foggi, Melissa Terranova, Matteo Daghio, Sergej L. Amelchanka, Giuseppe Conte, Simon Ineichen, Monica Agnolucci, Carlo Viti, Alberto Mantino, Arianna Buccioni, Michael Kreuzer, Marcello Mele
Dietary supplements based on tannin extracts or essential oil compounds (EOC) have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry. A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia formation. Among these, Q-2 (named after quebracho
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Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-04-01 Xiurong Zhao, Junhui Wen, Xinye Zhang, Jinxin Zhang, Tao Zhu, Huie Wang, Weifang Yang, Guomin Cao, Wenjie Xiong, Yong Liu, Changqing Qu, Zhonghua Ning, Lujiang Qu
Chicken is one of the most numerous and widely distributed species around the world, and many studies support the multiple ancestral origins of domestic chickens. The research regarding the yellow skin phenotype in domestic chickens (regulated by BCO2) likely originating from the grey junglefowl serves as crucial evidence for demonstrating the multiple origins of chickens. However, beyond the BCO2
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Low crude protein formulation with supplemental amino acids for its impacts on intestinal health and growth performance of growing-finishing pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-25 Marcos Elias Duarte, Wanpuech Parnsen, Shihai Zhang, Márvio L. T. Abreu, Sung Woo Kim
Low crude protein (CP) formulations with supplemental amino acids (AA) are used to enhance intestinal health, reduce costs, minimize environmental impact, and maintain growth performance of pigs. However, extensive reduction of dietary CP can compromise growth performance due to limited synthesis of non-essential AA and limited availability of bioactive compounds from protein supplements even when
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Effects of the kinetic pattern of dietary glucose release on nitrogen utilization, the portal amino acid profile, and nutrient transporter expression in intestinal enterocytes in piglets J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-18 Zexi Li, Yunfei Li, Yufei Zhao, Guifu Wang, Rujie Liu, Yue Li, Qamar Aftab, Zewei Sun, Qingzhen Zhong
Promoting the synchronization of glucose and amino acid release in the digestive tract of pigs could effectively improve dietary nitrogen utilization. The rational allocation of dietary starch sources and the exploration of appropriate dietary glucose release kinetics may promote the dynamic balance of dietary glucose and amino acid supplies. However, research on the effects of diets with different
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Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-14 Le Zhao, Haili Yang, Minhao Li, Min Xiao, Xingchun Li, Lei Cheng, Wenqiang Cheng, Meixi Chen, Yongju Zhao
Brown adipose tissue (BAT) is known to be capable of non-shivering thermogenesis under cold stimulation, which is related to the mortality of animals. In the previous study, we observed that goat BAT is mainly located around the kidney at birth, and changes to white adipose tissue (WAT) in the perirenal adipose tissue of goats within one month after birth. However, the regulatory factors underlying
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Multi-omics integration identifies regulatory factors underlying bovine subclinical mastitis J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-14 Mengqi Wang, Naisu Yang, Mario Laterrière, David Gagné, Faith Omonijo, Eveline M. Ibeagha-Awemu
Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy industry. Multi-omics approaches enable the comprehensive investigation of the complex interactions between multiple layers of information to provide a more holistic view of disease pathogenesis. Therefore, this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms
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Staphylococcus aureus and biofilms: transmission, threats, and promising strategies in animal husbandry J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-13 Mengda Song, Qi Tang, Yakun Ding, Peng Tan, Yucheng Zhang, Tao Wang, Chenlong Zhou, Shenrui Xu, Mengwei Lyu, Yueyu Bai, Xi Ma
Staphylococcus aureus (S. aureus) is a common pathogenic bacterium in animal husbandry that can cause diseases such as mastitis, skin infections, arthritis, and other ailments. The formation of biofilms threatens and exacerbates S. aureus infection by allowing the bacteria to adhere to pathological areas and livestock product surfaces, thus triggering animal health crises and safety issues with livestock
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In-depth proteome characterization of endometrium and extraembryonic membranes during implantation in pig J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-12 Maria A. Gil, Josep M. Cambra, Heriberto Rodriguez-Martinez, Cristina Cuello, Inmaculada Parrilla, Emilio A. Martinez
Proteome characterization of the porcine endometrium and extraembryonic membranes is important to understand mother-embryo cross-communication. In this study, the proteome of the endometrium and chorioallantoic membrane was characterized in pregnant sows (PS) during early gestation (d 18 and 24 of gestation) and in the endometrium of non-pregnant sows (NPS) during the same days using LC-MS/MS analysis
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High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-11 Haorong He, Yuanhang Wei, Yuqi Chen, Xiyu Zhao, Xiaoxu Shen, Qing Zhu, Huadong Yin
The reproductive performance of chickens mainly depends on the development of follicles. Abnormal follicle development can lead to decreased reproductive performance and even ovarian disease among chickens. Chicken is the only non-human animal with a high incidence of spontaneous ovarian cancer. In recent years, the involvement of circRNAs in follicle development and atresia regulation has been confirmed
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Betaine addition to the diet alleviates intestinal injury in growing rabbits during the summer heat through the AAT/mTOR pathway J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-08 Zimei Li, Junning Pu, Xiang Chen, Yanbin Chen, Xiaoyan Peng, Jingyi Cai, Gang Jia, Hua Zhao, Gang Tian
The aim of this experiment was to investigate the effect of different levels of betaine (Bet) inclusion in the diet on the intestinal health of growing rabbits under summer heat. A total of 100 weaned Qixing meat rabbits aged 35 d with body weight of 748.61 ± 38.59 g were randomly divided into 5 treatment groups: control group (basal diet) and Bet groups (basal diet + 0.75, 1.0, 1.5 or 2.0 g/kg Bet)
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Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-07 Yanli Liu, Zhuqing Zheng, Chaohui Wang, Yumeng Wang, Xi Sun, Zhouzheng Ren, Xin Yang, Xiaojun Yang
Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality rate. Three-dimensional (3D) chromatin architecture takes part in disease processing by regulating transcriptional reprogramming. The study is carried out to investigate the alterations of hepatic 3D genome and H3K27ac profiling in early fatty liver (FLS) and reveal their effect on hepatic
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Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin-producing E. coli challenged weaned piglets J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-06 Matthias Dierick, Ruben Ongena, Daisy Vanrompay, Bert Devriendt, Eric Cox
Post-weaned piglets suffer from F18+ Escherichia coli (E. coli) infections resulting in post-weaning diarrhoea or oedema disease. Frequently used management strategies, including colistin and zinc oxide, have contributed to the emergence and spread of antimicrobial resistance. Novel antimicrobials capable of directly interacting with pathogens and modulating the host immune responses are being investigated
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Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-06 Laman K. Mamedova, Kirby C. Krogstad, Paiton O. McDonald, Laxman Pokhrel, Duy H. Hua, Evan C. Titgemeyer, Barry J. Bradford
Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid (BHBA; the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a ligand of HCAR2 and the activation of these receptors promotes an anti-inflammatory response which may be related with immunosuppression
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Novel uses of ensiled biomasses as feedstocks for green biorefineries J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-05 Marketta Rinne
Perennial forage plants are efficient utilizers of solar radiation and nutrients so that there is a lot of scope to increase the production of green biomass in many areas. Currently, grasses are mainly used as feeds for ruminants and equines, but there could be higher added value use for several components of the green biomass. Interest in green biorefining has risen recently motivated by the increased
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Decreased eggshell strength caused by impairment of uterine calcium transport coincide with higher bone minerals and quality in aged laying hens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-04 Yu Fu, Jianmin Zhou, Martine Schroyen, Haijun Zhang, Shugeng Wu, Guanghai Qi, Jing Wang
Deteriorations in eggshell and bone quality are major challenges in aged laying hens. This study compared the differences of eggshell quality, bone parameters and their correlations as well as uterine physiological characteristics and the bone remodeling processes of hens laying eggs of different eggshell breaking strength to explore the mechanism of eggshell and bone quality reduction and their interaction
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Dietary xylo-oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-04 Carla Castro, Shahram Niknafs, Gemma Gonzalez-Ortiz, Xinle Tan, Michael R. Bedford, Eugeni Roura
One of the main roles of the intestinal mucosa is to protect against environmental hazards. Supplementation of xylo-oligosaccharides (XOS) is known to selectively stimulate the growth of beneficial intestinal bacteria and improve gut health and function in chickens. XOS may have an impact on the integrity of the intestinal epithelia where cell turnover is critical to maintain the compatibility between
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Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post-weaning period J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-03 Kayla Law, Eduardo Rosa Medina Garcia, Chad Hastad, Deborah Murray, Pedro E. Urriola, Andres Gomez
Nursery pigs undergo stressors in the post-weaning period that result in production and welfare challenges. These challenges disproportionately impact the offspring of primiparous sows compared to those of multiparous counterparts. Little is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig microbiomes. Therefore, the
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Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-02 Dohyung M. Kim, Jing Liu, Melanie A. Whitmore, Isabel Tobin, Zijun Zhao, Guolong Zhang
Necrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA) and butyrate, two major metabolites derived from the intestinal microbiota, have independently been shown to induce host defense peptide (HDP) synthesis. However, the potential synergy between these two compounds remains unexplored. To investigate the possible synergistic
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tRNAGlu-derived fragments from embryonic extracellular vesicles modulate bovine embryo hatching J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-03-01 Yuan Fan, Krishna Chaitanya Pavani, Katrien Smits, Ann Van Soom, Luc Peelman
Transfer RNA-derived small RNAs (tsRNAs) have been shown to be involved in early embryo development and repression of endogenous retroelements in embryos and stem cells. However, it is unknown whether tsRNAs also regulate embryo hatching. In this study, we mined the sequencing data of a previous experiment in which we demonstrated that the microRNA (miRNA) cargo of preimplantation embryonic extracellular
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Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-28 Yin Yin Kyawt, Min Aung, Yao Xu, Zhanying Sun, Yaqi Zhou, Weiyun Zhu, Varijakshapanicker Padmakumar, Zhankun Tan, Yanfen Cheng
Providing high-quality roughage is crucial for improvement of ruminant production because it is an essential component of their feed. Our previous study showed that feeding bio-fermented rice straw (BF) improved the feed intake and weight gain of sheep. However, it remains unclear why feeding BF to sheep increased their feed intake and weight gain. Therefore, the purposes of this research were to investigate
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Pig pangenome graph reveals functional features of non-reference sequences J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-22 Jian Miao, Xingyu Wei, Caiyun Cao, Jiabao Sun, Yuejin Xu, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang
The reliance on a solitary linear reference genome has imposed a significant constraint on our comprehensive understanding of genetic variation in animals. This constraint is particularly pronounced for non-reference sequences (NRSs), which have not been extensively studied. In this study, we constructed a pig pangenome graph using 21 pig assemblies and identified 23,831 NRSs with a total length of
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Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-21 Daojie Li, Hongying Cai, Guohua Liu, Yunsheng Han, Kai Qiu, Weiwei Liu, Kun Meng, Peilong Yang
Fatty liver hemorrhage syndrome (FLHS) becomes one of the most major factors resulting in the laying hen death for caged egg production. This study aimed to investigate the therapeutic effects of Lactiplantibacillus plantarum (Lp. plantarum) FRT4 on FLHS model in laying hen with a focus on liver lipid metabolism, and gut microbiota. The FLHS model of laying hens was established by feeding a high-energy
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Finding biomarkers of experience in animals J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-20 Sarah Babington, Alan J. Tilbrook, Shane K. Maloney, Jill N. Fernandes, Tamsyn M. Crowley, Luoyang Ding, Archa H. Fox, Song Zhang, Elise A. Kho, Daniel Cozzolino, Timothy J. Mahony, Dominique Blache
At a time when there is a growing public interest in animal welfare, it is critical to have objective means to assess the way that an animal experiences a situation. Objectivity is critical to ensure appropriate animal welfare outcomes. Existing behavioural, physiological, and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative outcomes. But
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Supplementation of vitamin E or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-19 Ysenia V. Silva-Guillen, Consuelo Arellano, Jeffrey Wiegert, R. Dean Boyd, Gabriela E. Martínez, Eric van Heugten
Heat stress has severe negative consequences on performance and health of pigs, leading to significant economic losses. The objective of this study was to investigate the effects of supplemental vitamin E and a botanical extract in feed or drinking water on growth performance, intestinal health, and oxidative and immune status in growing pigs housed under heat stress conditions. Duplicate experiments
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Establishment of a chicken intestinal organoid culture system to assess deoxynivalenol-induced damage of the intestinal barrier function J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-18 Tae Hong Kang, Sang In Lee
Deoxynivalenol (DON) is a mycotoxin that has received recognition worldwide because of its ability to cause growth delay, nutrient malabsorption, weight loss, emesis, and a reduction of feed intake in livestock. Since DON-contaminated feedstuff is absorbed in the gastrointestinal tract, we used chicken organoids to assess the DON-induced dysfunction of the small intestine. We established a culture
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Prevotella and succinate treatments altered gut microbiota, increased laying performance, and suppressed hepatic lipid accumulation in laying hens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-18 Min Liu, Zeyue Kang, Xikang Cao, Hongchao Jiao, Xiaojuan Wang, Jingpeng Zhao, Hai Lin
This work aimed to investigate the potential benefits of administering Prevotella and its primary metabolite succinate on performance, hepatic lipid accumulation and gut microbiota in laying hens. One hundred and fifty 58-week-old Hyline Brown laying hens, with laying rate below 80% and plasma triglyceride (TG) exceeding 5 mmol/L, were used in this study. The hens were randomly allocated into 5 groups
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Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-18 Mingkun Gao, Chaoyong Liao, Jianyang Fu, Zhonghua Ning, Zengpeng Lv, Yuming Guo
Baicalin and probiotic cocktails are promising feed additives with broad application prospects. While probiotic cocktails are known to enhance intestinal health, the potential synergistic impact of combining baicalin with probiotic cocktails on the gut health of broiler chickens remains largely unexplored. Therefore, this study aims to investigate the influence of the combined administration of baicalin
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Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non-essential blood AA profile in pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-18 Maximiliano Müller, Elout Van Liefferinge, Alan Tilbrook, Robert van Barneveld, Eugeni Roura
Commercial diets are frequently formulated to meet or exceed nutrient levels including those of limiting essential amino acids (AA) covering potential individual variations within the herd. However, the provision of dietary excess of AA, such as Lys, may lead to reduced appetite and growth in pigs. The mechanisms modulating these responses have not been extensively investigated. This study evaluated
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All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-09 Junning Pu, Daiwen Chen, Gang Tian, Jun He, Ping Zheng, Zhiqing Huang, Xiangbing Mao, Jie Yu, Yuheng Luo, Junqiu Luo, Hui Yan, Aimin Wu, Bing Yu
Transmissible gastroenteritis virus (TGEV) is one of the main pathogens causing severe diarrhea of piglets. The pathogenesis of TGEV is closely related to intestinal inflammation. All-trans retinoic acid (ATRA) is the main active metabolite of vitamin A, which has immunomodulatory and anti-inflammatory properties. However, it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation
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Oils with different degree of saturation: effects on ileal digestibility of fat and corresponding additivity and bacterial community in growing pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-07 Lu Wang, Yifan Chen, Yuansen Yang, Nuo Xiao, Changhua Lai
Oils are important sources of energy in pig diets. The combination of oils with different degree of saturation contributes to improve the utilization efficiency of the mixed oils and may reduce the cost of oil supplemented. An experiment was conducted to evaluate the effects of oils with different degree of saturation on the fat digestibility and corresponding additivity and bacterial community in
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Layer chicken microbiota: a comprehensive analysis of spatial and temporal dynamics across all major gut sections J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-05 Yadav Sharma Bajagai, Thi Thu Hao Van, Nitish Joat, Kapil Chousalkar, Robert J. Moore, Dragana Stanley
The gut microbiota influences chicken health, welfare, and productivity. A diverse and balanced microbiota has been associated with improved growth, efficient feed utilisation, a well-developed immune system, disease resistance, and stress tolerance in chickens. Previous studies on chicken gut microbiota have predominantly focused on broiler chickens and have usually been limited to one or two sections
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Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-04 Yan Lin, Jiangnan Wu, Yong Zhuo, Bin Feng, Zhengfeng Fang, Shengyu Xu, Jian Li, Hua Zhao, De Wu, Lun Hua, Lianqiang Che
Intrauterine growth retardation (IUGR) affects intestinal growth, morphology, and function, which leads to poor growth performance and high mortality. The present study explored whether maternal dietary methyl donor (MET) supplementation alleviates IUGR and enhances offspring’s growth performance by improving intestinal growth, function, and DNA methylation of the ileum in a porcine IUGR model. Forty
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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK-PGC-1α signaling pathway and alters the muscle fiber composition of sheep J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-04 Pengkang Song, Jiamin Zhao, Fanqinyu Li, Xiaoyi Zhao, Jinxin Feng, Yuan Su, Bo Wang, Junxing Zhao
Vitamin A (VA) and its metabolite, retinoic acid (RA), are of great interest for their wide range of physiological functions. However, the regulatory contribution of VA to mitochondrial and muscle fiber composition in sheep has not been reported. Lambs were injected with 0 (control) or 7,500 IU VA palmitate into the biceps femoris muscle on d 2 after birth. At the age of 3 and 32 weeks, longissimus
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Repeated inoculation with rumen fluid accelerates the rumen bacterial transition with no benefit on production performance in postpartum Holstein dairy cows J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-04 Fanlin Kong, Feiran Wang, Yijia Zhang, Shuo Wang, Wei Wang, Shengli Li
The dairy cow’s postpartum period is characterized by dramatic physiological changes, therefore imposing severe challenges on the animal for maintaining health and milk output. The dynamics of the ruminal microbiota are also tremendous and may play a crucial role in lactation launch. We aim to investigate the potential benefits of early microbial intervention by fresh rumen microbiota transplantation
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Coated sodium butyrate ameliorates high-energy and low-protein diet induced hepatic dysfunction via modulating mitochondrial dynamics, autophagy and apoptosis in laying hens J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-02 Sasa Miao, Tianming Mu, Ru Li, Yan Li, Wenyan Zhao, Jiankui Li, Xinyang Dong, Xiaoting Zou
Fatty liver hemorrhagic syndrome (FLHS), a fatty liver disease in laying hens, poses a grave threat to the layer industry, stemming from its ability to trigger an alarming plummet in egg production and usher in acute mortality among laying hens. Increasing evidence suggests that the onset and progression of fatty liver was closely related to mitochondria dysfunction. Sodium butyrate was demonstrated
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Sperm function, mitochondrial activity and in vivo fertility are associated to their mitochondrial DNA content in pigs J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-02-01 Marc Llavanera, Yentel Mateo-Otero, Estel Viñolas-Vergés, Sergi Bonet, Marc Yeste
Despite their low abundance in sperm, mitochondria have diverse functions in this cell type, including energy production, signalling and calcium regulation. In humans, sperm mitochondrial DNA content (mtDNAc) has been reported to be negatively linked to sperm function and fertility. Yet, the association between mtDNAc and sperm function in livestock remains unexplored. For this reason, this study aimed
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The chemical characteristics of different sodium iron ethylenediaminetetraacetate sources and their relative bioavailabilities for broilers fed with a conventional corn-soybean meal diet J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-01-30 Shengchen Wang, Bingxin Wu, Ling Zhu, Weiyun Zhang, Liyang Zhang, We Wu, Jiaqi Wu, Yun Hu, Tingting Li, Xiaoyan Cui, Xugang Luo
Our previous studies demonstrated that divalent organic iron (Fe) proteinate sources with higher complexation or chelation strengths as expressed by the greater quotient of formation (Qf) values displayed higher Fe bioavailabilities for broilers. Sodium iron ethylenediaminetetraacetate (NaFeEDTA) is a trivalent organic Fe source with the strongest chelating ligand EDTA. However, the bioavailability
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Insights into the mechanism of L-malic acid on drip loss of chicken meat under commercial conditions J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-01-29 Haijun Sun, Xue Yan, Lu Wang, Ruimin Zhu, Meixia Chen, Jingdong Yin, Xin Zhang
A deterioration in the meat quality of broilers has attracted much more attention in recent years. L-malic acid (MA) is evidenced to decrease meat drip loss in broilers, but the underlying molecular mechanisms are still unclear. It’s also not sure whether the outputs obtained under experimental conditions can be obtained in a commercial condition. Here, we investigated the effects and mechanisms of
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Abomasal infusion of branched-chain amino acids or branched-chain keto-acids alter lactation performance and liver triglycerides in fresh cows J. Anim. Sci. Biotechnol. (IF 7.0) Pub Date : 2024-01-29 Kristen Gallagher, Isabelle Bernstein, Cynthia Collings, David Main, Ghayyoor Ahmad, Sarah Naughton, Jayasimha Daddam, Vengai Mavangira, Mike Vandehaar, Zheng Zhou
Dairy cows are at high risk of fatty liver disease in early lactation, but current preventative measures are not always effective. Cows with fatty liver have lower circulating branched-chain amino acid (BCAA) concentrations whereas cows with high circulating BCAA levels have low liver triglyceride (TG). Our objective was to determine the impact of BCAA and their corresponding ketoacids (branched-chain