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I strive to make the Great Barrier Reef more resilient to heat stress Nature (IF 64.8) Pub Date : 2024-04-29
Matthew Nitschke grows coral symbionts in a slowly warming tank to prepare reef life for climate change.
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Superconductivity hunt gets boost from China's $220 million physics 'playground' Nature (IF 64.8) Pub Date : 2024-04-29
From extreme cold to strong magnets and high pressures, the Synergetic Extreme Condition User Facility (SECUF) provides conditions for researching these potential wonder materials.
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Elephant-nose fish ‘see’ farther by electric sensing when in groups Nature (IF 64.8) Pub Date : 2024-04-29
The elephant-nose fish detects electric pulses from its neighbours to extend the distance over which it senses objects.
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85 million cells — and counting — at your fingertips Nature (IF 64.8) Pub Date : 2024-04-29
Chan Zuckerberg CELL by GENE Discover aims to be a one-stop shop for single-cell RNA sequencing data storage, access and analysis.
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Daily briefing: Gaze upon the most detailed Moon maps ever made Nature (IF 64.8) Pub Date : 2024-04-26
The new Geologic Atlas took more than 100 researchers over a decade to compile. Plus, how gliding marsupials got their ‘wings’ and H5N1 bird flu virus material has been detected in US milk.
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Bird flu virus has been spreading in US cows for months, RNA reveals Nature (IF 64.8) Pub Date : 2024-04-27
Genomic analysis suggests that the outbreak probably began in December or January, but a shortage of data is hampering efforts to pin down the source.
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Want to make a difference? Try working at an environmental non-profit organization Nature (IF 64.8) Pub Date : 2024-04-26
Moving to non-profit work requires researchers to shift their mindset to focus on applied science for policymaking and conservation practice.
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Corporate emissions targets and the neglect of future innovators Science (IF 56.9) Pub Date : 2024-04-26 Yann Robiou du Pont, Joeri Rogelj, Angel Hsu, Detlef van Vuuren, Andreas G. F. Hoepner
Widely recognized as key partners for achieving international climate goals (1, 2), businesses like to indicate that their targets and activities are “Paris-aligned.” In response, research and initiatives have emerged to guide and assess whether companies’ targets represent an adequate mitigation effort to achieve the Paris Agreement. Here, we highlight conceptual limitations of effort-sharing approaches
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A sound beginning of life starts before birth Science (IF 56.9) Pub Date : 2024-04-26 Hans Slabbekoorn
The acoustic environment of animals and humans has never been quiet, encompassing all sounds, from natural to those made by humans. The effect of sound on physiology and development starts before birth, which is why a world that grows increasingly more noisy, with loud outdoor entertainment, construction, and traffic, is a concern. On page 475 of this issue, Meillère et al. (1) report that exposure
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Microbes and vitamin D aid immunotherapy Science (IF 56.9) Pub Date : 2024-04-26 Fabien Franco, Kathy D. McCoy
Tremendous progress has been made in improving cancer immunotherapy, which is now established as a pillar for cancer treatment. Immune checkpoint inhibitors (ICIs) enhance antitumoral T cell responses by blocking interactions of the inhibitory receptors cytotoxic T lymphocyte–associated protein 4 (CTLA-4) or programmed cell death protein 1 (PD-1) that are expressed on T cells with their ligands. ICIs
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Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules Science (IF 56.9) Pub Date : 2024-04-26 Daniel O. Dodd, Sabrina Mechaussier, Patricia L. Yeyati, Fraser McPhie, Jacob R. Anderson, Chen Jing Khoo, Amelia Shoemark, Deepesh K. Gupta, Thomas Attard, Maimoona A. Zariwala, Marie Legendre, Diana Bracht, Julia Wallmeier, Miao Gui, Mahmoud R. Fassad, David A. Parry, Peter A. Tennant, Alison Meynert, Gabrielle Wheway, Lucas Fares-Taie, Holly A. Black, Rana Mitri-Frangieh, Catherine Faucon, Josseline
Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type– and context-specific microtubule structures is poorly understood. Based on a cohort of 12 patients with primary ciliary dyskinesia as well as mouse mutants, we identified and characterized variants in the TUBB4B isotype
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Audio long read: Why loneliness is bad for your health Nature (IF 64.8) Pub Date : 2024-04-26
Listen to an audio version of a recent Nature Feature.
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Could a rare mutation that causes dwarfism also slow ageing? Nature (IF 64.8) Pub Date : 2024-04-26
People with Laron syndrome have a low risk of heart disease and a number of other age-related disorders, hinting at strategies for new treatments.
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Future of Humanity Institute shuts: what’s next for ‘deep future’ research? Nature (IF 64.8) Pub Date : 2024-04-26
Researchers from several disciplines hope to predict — and prevent — scenarios that pose risks to humanity.
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Garden-variety fungus is an expert at environmental clean-ups Nature (IF 64.8) Pub Date : 2024-04-25
The common fungus Aspergillus niger removes both heavy metals and organic pollutants from its surroundings.
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Air-travel climate-change emissions detailed for nearly 200 nations Nature (IF 64.8) Pub Date : 2024-04-25
Carbon emissions from flights that departed from low- and middle-income countries in 2019 totalled 417 million tonnes.
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Rat neurons repair mouse brains — and restore sense of smell Nature (IF 64.8) Pub Date : 2024-04-25
Scientists develop hybrid mice by filling in missing cells and structures in their brains with rat stem cells.
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Hello puffins, goodbye belugas: changing Arctic fjord hints at our climate future Nature (IF 64.8) Pub Date : 2024-04-25
Stunning images show an ecosystem’s upheaval as it warms at an alarming pace.
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Scientists urged to collect royalties from the ‘magic money tree’ Nature (IF 64.8) Pub Date : 2024-04-25
By joining a collecting society, researchers can ensure they are paid when copyrighted book content and papers are reproduced.
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Daily briefing: How an unlikely friendship with Jung influenced Pauli’s physics Nature (IF 64.8) Pub Date : 2024-04-25
A patient-analyst relationship to psychoanalyst Carl Jung that evolved into a friendship deeply influenced physicist Wolfgang Pauli’s work. Plus, organoids shed light on cancer and other diseases, and medieval graves reveal secrets of a mysterious nomadic people.
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NIH pay raise for postdocs and PhD students could have US ripple effect Nature (IF 64.8) Pub Date : 2024-04-25
Salary increases for the 17,000-plus recipients of an NIH research award could lead to increases in other academic settings.
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Bird flu in US cows: is the milk supply safe? Nature (IF 64.8) Pub Date : 2024-04-25
Pasteurized milk is probably not a threat to people, but fresh milk droplets on milking equipment could be spreading the virus in a herd.
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Judge dismisses superconductivity physicist’s lawsuit against university Nature (IF 64.8) Pub Date : 2024-04-25
Ranga Dias sued his university, in part, for allegedly conducting a biased investigation, which found he had committed extensive scientific misconduct.
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Daily briefing: The origins of bioluminescence in animals date back over half a billion years Nature (IF 64.8) Pub Date : 2024-04-24
Octocorals probably evolved the ability to make light when the first animals developed eyes. Plus, the WHO has redefined ‘airborne transmission’ and how artificial intelligence is changing weapons of war.
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How DNA encodes the start of transcription Science (IF 56.9) Pub Date : 2024-04-26 Jun Wang, Vikram Agarwal
The central dogma of molecular biology outlines the flow of genetic information from DNA to RNA to proteins. With a limited vocabulary of four nucleotides (A, C, G, and T), DNA encodes an extensive instruction set, including the chromosomal positions where RNAs begin to be transcribed and the magnitudes of their expression. This process, known as transcription initiation (1), begins at transcription
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Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Fredrick Kizito, Kien Nguyen, Uri Mbonye, Meenakshi Shukla, Benjamin Luttge, Mary Ann Checkley, Anna Agaponova, Konstantin Leskov, Jonathan Karn
Using an immunofluorescence assay based on CRISPR-dCas9-gRNA complexes that selectively bind to the HIV LTR (HIV Cas-FISH), we traced changes in HIV DNA localization in primary effector T cells from early infection until the cells become quiescent as they transition to memory cells. Unintegrated HIV DNA colocalized with CPSF6 and HIV capsid (CA, p24) was found in the cytoplasm and nuclear periphery
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Machine learning enables identification of an alternative yeast galactose utilization pathway Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Marie-Claire Harrison, Emily J. Ubbelohde, Abigail L. LaBella, Dana A. Opulente, John F. Wolters, Xiaofan Zhou, Xing-Xing Shen, Marizeth Groenewald, Chris Todd Hittinger, Antonis Rokas
How genomic differences contribute to phenotypic differences is a major question in biology. The recently characterized genomes, isolation environments, and qualitative patterns of growth on 122 sources and conditions of 1,154 strains from 1,049 fungal species (nearly all known) in the yeast subphylum Saccharomycotina provide a powerful, yet complex, dataset for addressing this question. We used a
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Limits of economy and fidelity for programmable assembly of size-controlled triply periodic polyhedra Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Carlos M. Duque, Douglas M. Hall, Botond Tyukodi, Michael F. Hagan, Christian D. Santangelo, Gregory M. Grason
We propose and investigate an extension of the Caspar–Klug symmetry principles for viral capsid assembly to the programmable assembly of size-controlled triply periodic polyhedra, discrete variants of the Primitive, Diamond, and Gyroid cubic minimal surfaces. Inspired by a recent class of programmable DNA origami colloids, we demonstrate that the economy of design in these crystalline assemblies—in
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Negative correlation between soil salinity and soil organic carbon variability Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Amirhossein Hassani, Pete Smith, Nima Shokri
Soil organic carbon (SOC) is vital for terrestrial ecosystems, affecting biogeochemical processes, and soil health. It is known that soil salinity impacts SOC content, yet the specific direction and magnitude of SOC variability in relation to soil salinity remain poorly understood. Analyzing 43,459 mineral soil samples (SOC < 150 g kg −1 ) collected across different land covers since 1992, we approximate
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Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Qing He, Feng Wang, Michael E. O’Donnell, Huilin Li
The DNA sliding clamp PCNA is a multipurpose platform for DNA polymerases and many other proteins involved in DNA metabolism. The topologically closed PCNA ring needs to be cracked open and loaded onto DNA by a clamp loader, e.g., the well-studied pentameric ATPase complex RFC (RFC1-5). The CTF18-RFC complex is an alternative clamp loader found recently to bind the leading strand DNA polymerase ε and
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Dissection and integration of bursty transcriptional dynamics for complex systems Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Cheng Frank Gao, Suriyanarayanan Vaikuntanathan, Samantha J. Riesenfeld
RNA velocity estimation is a potentially powerful tool to reveal the directionality of transcriptional changes in single-cell RNA-sequencing data, but it lacks accuracy, absent advanced metabolic labeling techniques. We developed an approach, TopicVelo , that disentangles simultaneous, yet distinct, dynamics by using a probabilistic topic model, a highly interpretable form of latent space factorization
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On nonlinear buckling of microshells Int. J. Eng. Sci. (IF 6.6) Pub Date : 2024-04-26 Sayed Mohamad Mirfatah, Mohammad Amin Shahmohammadi, Hamzeh Salehipour, Ömer Civalek
Investigation of the geometrical nonlinear action of doubly curved shell panels (DCSPs) in micro scale is the main target of this paper. The proposed microshell panels (MSPs) are assumed to be made of an auxetic honeycomb core (AHOC), leading to negative magnitudes of Poisson's ratio, covered by two nanocomposite enriched coating layers (NCECLs). To conduct the size-dependent nonlinear analysis and
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China's Moon atlas is the most detailed ever made Nature (IF 64.8) Pub Date : 2024-04-25
The Geologic Atlas of the Lunar Globe doubles the resolution of Apollo-era maps and will support the space ambitions of China and other countries.
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‘Shut up and calculate’: how Einstein lost the battle to explain quantum reality Nature (IF 64.8) Pub Date : 2024-04-25
By suppressing questions they considered too ‘philosophical’, post-war physicists created an unquestioning orthodoxy that influences science to this day.
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Algorithm ranks peer reviewers by reputation — but critics warn of bias Nature (IF 64.8) Pub Date : 2024-04-25
There are questions about whether the tool, which could be used by editors to find and shortlist peer reviewers, would disadvantage inexperienced candidates or those in certain locations.
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NATO is boosting AI and climate research as scientific diplomacy remains on ice Nature (IF 64.8) Pub Date : 2024-04-25
As the military alliance created to counter the Soviet Union expands, it is prioritizing studies on how climate change affects security, cyber attacks and election interference.
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Are robots the solution to the crisis in older-person care? Nature (IF 64.8) Pub Date : 2024-04-25
Social robots that promise companionship and stimulation for older people and those with dementia are attracting investment, but some question their benefits.
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Structures of human γδ T cell receptor–CD3 complex Nature (IF 64.8) Pub Date : 2024-04-24 Weizhi Xin, Bangdong Huang, Ximin Chi, Yuehua Liu, Mengjiao Xu, Yuanyuan Zhang, Xu Li, Qiang Su, Qiang Zhou
Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology1-3. The γδ T cell receptor (TCR), generated by γδ T cells, recognizes a diverse range of antigens independently of the major histocompatibility complex2. The γδ TCR associates with CD3 subunits, initiating T cell activation and holding great potential in immunotherapy4. Here, we report the
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How gliding marsupials got their ‘wings’ Nature (IF 64.8) Pub Date : 2024-04-24
Hear the biggest stories from the world of science | 24 April 2024
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Should the Maldives be creating new land? Nature (IF 64.8) Pub Date : 2024-04-24
The Maldives are racing to reclaim vast amounts of land to combat rising sea levels. But many are concerned that these efforts risk harming the paradise they aims to protect
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This giant extinct salmon had tusks like a warthog Nature (IF 64.8) Pub Date : 2024-04-24
Scientists initially thought that the outsized teeth were fangs, giving rise to the ‘sabre-toothed salmon’ nickname.
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High-performance fibre battery with polymer gel electrolyte Nature (IF 64.8) Pub Date : 2024-04-24 Chenhao Lu, Haibo Jiang, Xiangran Cheng, Jiqing He, Yao Long, Yingfan Chang, Xiaocheng Gong, Kun Zhang, Jiaxin Li, Zhengfeng Zhu, Jingxia Wu, Jiajia Wang, Yuanyuan Zheng, Xiang Shi, Lei Ye, Meng Liao, Xuemei Sun, Bingjie Wang, Peining Chen, Yonggang Wang, Huisheng Peng
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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers Nature (IF 64.8) Pub Date : 2024-04-24 Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler, Rita Andraos-Rey, Stephanie Barbe, Elisabeth Bechter, Jutta Blank, Vincent Bordas, Ernesta Dammassa, Andrea Decker, Noemi Di Nanni, Marion Dourdoigne, Elena Gavioli, Marc Hattenberger, Alisa Heuser, Christelle Hemmerlin, Jürgen Hinrichs, Grainne Kerr, Laurent Laborde, Isabel Jaco, Eloísa Jiménez Núñez, Hans-Joerg Martus, Cornelia
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Antisense oligonucleotide therapeutic approach for Timothy syndrome Nature (IF 64.8) Pub Date : 2024-04-24 Xiaoyu Chen, Fikri Birey, Min-Yin Li, Omer Revah, Rebecca Levy, Mayuri Vijay Thete, Noah Reis, Konstantin Kaganovsky, Massimo Onesto, Noriaki Sakai, Zuzana Hudacova, Jin Hao, Xiangling Meng, Seiji Nishino, John Huguenard, Sergiu P. Pașca
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Multi-project wafers for flexible thin-film electronics by independent foundries Nature (IF 64.8) Pub Date : 2024-04-24 Hikmet Çeliker, Wim Dehaene, Kris Myny
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Growth of diamond in liquid metal at 1 atm pressure Nature (IF 64.8) Pub Date : 2024-04-24 Yan Gong, Da Luo, Myeonggi Choe, Yongchul Kim, Babu Ram, Mohammad Zafari, Won Kyung Seong, Pavel Bakharev, Meihui Wang, In Kee Park, Seulyi Lee, Tae Joo Shin, Zonghoon Lee, Geunsik Lee, Rodney S. Ruoff
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PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells Nature (IF 64.8) Pub Date : 2024-04-24 Sebastian B. Lacher, Janina Dörr, Gustavo P. de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J. Rudolph, Nadine Spranger, Matteo Morotti, Alizee J. Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H. Busch, Veit R. Buchholz
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A high-density and high-confinement tokamak plasma regime for fusion energy Nature (IF 64.8) Pub Date : 2024-04-24 S. Ding, A. M. Garofalo, H. Q. Wang, D. B. Weisberg, Z. Y. Li, X. Jian, D. Eldon, B. S. Victor, A. Marinoni, Q. M. Hu, I. S. Carvalho, T. Odstrčil, L. Wang, A. W. Hyatt, T. H. Osborne, X. Z. Gong, J. P. Qian, J. Huang, J. McClenaghan, C. T. Holcomb, J. M. Hanson
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Single-cell analysis reveals context-dependent, cell-level selection of mtDNA Nature (IF 64.8) Pub Date : 2024-04-24 Anna V. Kotrys, Timothy J. Durham, Xiaoyan A. Guo, Venkata R. Vantaku, Sareh Parangi, Vamsi K. Mootha
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase Nature (IF 64.8) Pub Date : 2024-04-24 Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons, Chu-Chiao Wu, Melissa A. Hoffman, Aaron N. Snead, Xiaodan Song, Thomas Glaza, Shota Kikuchi, Jason C. Green, Donald C. Rogness, Betty Lam, Maria E. Rodriguez-Aguirre, David R. Woody, Christie L. Eissler, Socorro Rodiles, Seth M. Negron, Steffen M. Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N. Williams, Martha
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A magnetar giant flare in the nearby starburst galaxy M82 Nature (IF 64.8) Pub Date : 2024-04-24 Sandro Mereghetti, Michela Rigoselli, Ruben Salvaterra, Dominik Patryk Pacholski, James Craig Rodi, Diego Gotz, Edoardo Arrigoni, Paolo D’Avanzo, Christophe Adami, Angela Bazzano, Enrico Bozzo, Riccardo Brivio, Sergio Campana, Enrico Cappellaro, Jerome Chenevez, Fiore De Luise, Lorenzo Ducci, Paolo Esposito, Carlo Ferrigno, Matteo Ferro, Gian Luca Israel, Emeric Le Floc’h, Antonio Martin-Carrillo,
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Whole-cortex in situ sequencing reveals input-dependent area identity Nature (IF 64.8) Pub Date : 2024-04-24 Xiaoyin Chen, Stephan Fischer, Mara C. P. Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O. Kanold, Jesse Gillis, Anthony M. Zador
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Periportal macrophages protect against commensal-driven liver inflammation Nature (IF 64.8) Pub Date : 2024-04-24 Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii
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High carrier mobility along the [111] orientation in Cu2O photoelectrodes Nature (IF 64.8) Pub Date : 2024-04-24 Linfeng Pan, Linjie Dai, Oliver J. Burton, Lu Chen, Virgil Andrei, Youcheng Zhang, Dan Ren, Jinshui Cheng, Linxiao Wu, Kyle Frohna, Anna Abfalterer, Terry Chien-Jen Yang, Wenzhe Niu, Meng Xia, Stephan Hofmann, Paul J. Dyson, Erwin Reisner, Henning Sirringhaus, Jingshan Luo, Anders Hagfeldt, Michael Grätzel, Samuel D. Stranks
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Probing entanglement in a 2D hard-core Bose–Hubbard lattice Nature (IF 64.8) Pub Date : 2024-04-24 Amir H. Karamlou, Ilan T. Rosen, Sarah E. Muschinske, Cora N. Barrett, Agustin Di Paolo, Leon Ding, Patrick M. Harrington, Max Hays, Rabindra Das, David K. Kim, Bethany M. Niedzielski, Meghan Schuldt, Kyle Serniak, Mollie E. Schwartz, Jonilyn L. Yoder, Simon Gustavsson, Yariv Yanay, Jeffrey A. Grover, William D. Oliver
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One-dimensional proximity superconductivity in the quantum Hall regime Nature (IF 64.8) Pub Date : 2024-04-24 Julien Barrier, Minsoo Kim, Roshan Krishna Kumar, Na Xin, P. Kumaravadivel, Lee Hague, E. Nguyen, A. I. Berdyugin, Christian Moulsdale, V. V. Enaldiev, J. R. Prance, F. H. L. Koppens, R. V. Gorbachev, K. Watanabe, T. Taniguchi, L. I. Glazman, I. V. Grigorieva, V. I. Fal’ko, A. K. Geim
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Transient loss of Polycomb components induces an epigenetic cancer fate Nature (IF 64.8) Pub Date : 2024-04-24 V. Parreno, V. Loubiere, B. Schuettengruber, L. Fritsch, C. C. Rawal, M. Erokhin, B. Győrffy, D. Normanno, M. Di Stefano, J. Moreaux, N. L. Butova, I. Chiolo, D. Chetverina, A.-M. Martinez, G. Cavalli
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Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo Nature (IF 64.8) Pub Date : 2024-04-24 L. Francisco Lorenzo-Martín, Tania Hübscher, Amber D. Bowler, Nicolas Broguiere, Jakob Langer, Lucie Tillard, Mikhail Nikolaev, Freddy Radtke, Matthias P. Lutolf
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Valleytronics in bulk MoS2 with a topologic optical field Nature (IF 64.8) Pub Date : 2024-04-24 Igor Tyulnev, Álvaro Jiménez-Galán, Julita Poborska, Lenard Vamos, Philip St. J. Russell, Francesco Tani, Olga Smirnova, Misha Ivanov, Rui E. F. Silva, Jens Biegert
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Regioselective hydroformylation of propene catalysed by rhodium-zeolite Nature (IF 64.8) Pub Date : 2024-04-24 Xiangjie Zhang, Tao Yan, Huaming Hou, Junqing Yin, Hongliu Wan, Xiaodong Sun, Qing Zhang, Fanfei Sun, Yao Wei, Mei Dong, Weibin Fan, Jianguo Wang, Yujie Sun, Xiong Zhou, Kai Wu, Yong Yang, Yongwang Li, Zhi Cao