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Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-14 Alba Ortigosa‐Palomo, David Fuentes‐Ríos, Francisco Quiñonero, Consolación Melguizo, Raul Ortiz, Juan M. López‐Romero, Jose Prados
Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits. However, to date, its antiproliferative properties have not been tested. The aim of this study was to analyze the cytotoxic effects of siphonochilone
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Hedyotis diffusa Willd inhibits inflammation and oxidative stress to protect against chronic prostatitis via the NRF2/ARE signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-13 Junfu Mo, Kang Xia, Chaokui Wu
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common and serious disease with unclear pathogenesis and recurrent symptoms. Hedyotis diffusa Willd (HDW) has been recognized for its potential in managing various chronic inflammatory diseases. This research aimed to interrogate the mechanism of HDW in treating CP/CPPS. Complete Freund Adjuvant (CFA) and LPS were utilized to establish
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PUM2 promoted osteoarthritis progression through PTEN‐mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-11 Yu Meng, Li Chen, Yuxia Chai, Weili Meng, Guohui Yang, Jia Ren, Hongshuai Li, Peiyi Qi, Juwu Chen, Nan Wang
Osteoarthritis (OA) is a prevalent degenerative joint disease with a lack of effective therapeutic. Chondrocyte ferroptosis contributes to the progression of OA. PUM2 is shown to exacerbate ischemia–reperfusion‐induced neuroinflammation by promoting ferroptosis, but its role in OA remains unexplored. Here, primary mouse chondrocytes were stimulated with IL‐1β to mimic OA chondrocyte injury in vitro
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Functional mechanism of hypoxia‐like conditions mediating resistance to ferroptosis in cervical cancer cells by regulating KDM4A SUMOylation and the SLC7A11/GPX4 pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-10 Jing Xiong, Puxiang Chen, Ling He, Xiaoshan Chai, Yongjing Zhang, Shujuan Sun
The discovery of ferroptosis has unveiled new perspectives for cervical cancer (CC) management. We elucidated the functional mechanism of hypoxia‐like conditions in CC cell ferroptosis resistance. CC cells were subjected to normoxia or hypoxia‐like conditions, followed by erastin treatment to induce ferroptosis. The assessment of cell viability/ferroptosis resistance was performed by MTT assay/Fe2+
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Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO‐1/GPX4 pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-10 Lei Huang, Jiayi Wang, Jieqin Yu, Mengxuan Bian, Xingdong Xiang, Guanjie Han, Weisin Chen, Ning Wang, Jun Ge, Shunyi Lu, Jian Zhang
Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to abnormal oxidative stress and high levels of reactive oxygen species (ROS), a condition detrimental for bone formation, making the OP‐related bone healing a significant clinical challenge. As the osteogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) is closely related to bone regeneration;
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Unraveling the immunogenic cell death pathways in gastric adenocarcinoma: A multi‐omics study Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-08 Renjun Gu, Zilu Chen, Mengyue Dong, Ziyun Li, Min Wang, Hao Liu, Xinyu Shen, Yan Huang, Jin Feng, Kun Mei
BackgroundGastric cancer (GC) is a prevalent malignant tumor of the gastrointestinal (GI) system. However, the lack of reliable biomarkers has made its diagnosis, prognosis, and treatment challenging. Immunogenic cell death (ICD) is a type of programmed cell death that is strongly related to the immune system. However, its function in GC requires further investigation.MethodWe used multi‐omics and
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Deoxyshikonin triggers apoptosis in cervical cancer cells through p38 MAPK‐mediated caspase activation Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-08 Chung‐Yuan Lee, Pei‐Ni Chen, Shao‐Hsuan Kao, Heng‐Hsiung Wu, Yi‐Hsuan Hsiao, Tzu‐Yu Huang, Po‐Hui Wang, Shun‐Fa Yang
Deoxyshikonin (DSK) is a biological component derived from Lithospermum erythrorhizon. Although DSK possesses potential anticancer activities, whether DSK exerts anticancer effects on cervical cancer cells is incompletely explored. This study was aimed to investigate the anticancer activity of DSK against cervical cancer cells and its molecular mechanisms. Cell viability was evaluated by MTT assay
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Influence of administration timing of San‐Huang‐Xie‐Xin‐Tang treatment on attenuating Salmonella enterica serovar Typhimurium infection Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-08 Chiung‐Hung Chang, Shu‐Chiu Wang, Chia‐Ying Lee, Chiu‐Hsian Su, Yen‐Ju Lai, Wei‐De Lin, Yuan‐Man Hsu
Salmonella infections are a serious global health concern, particularly in developing countries, and are further exacerbated by the emergence of antibiotic resistance. San‐Huang‐Xie‐Xin‐Tang (SHXXT), a traditional herbal medicine with potent anti‐inflammatory properties, has recently gained attention as an alternative treatment. Our study emphasizes on the importance of precise timing in accordance
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Environmentally relevant levels of Cd and Mo coexposure induces ferroptosis and excess ferritinophagy through AMPK/mTOR axis in duck myocardium Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-08 Bingyan Huang, Gaohui Nie, Xueyan Dai, Ting Cui, Wenjing Pu, Caiying Zhang
Cadmium (Cd) and excess molybdenum (Mo) are multiorgan toxic, but the detrimental impacts of Cd and/or Mo on poultry have not been fully clarified. Thence, a 16‐week sub‐chronic toxic experiment was executed with ducks to assess the toxicity of Cd and/or Mo. Our data substantiated that Cd and Mo coexposure evidently reduced GSH‐Px, GSH, T‐SOD, and CAT activities and elevated H2O2 and MDA concentrations
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Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-07 Charles S. da Costa, Thiago F. de Oliveira, Flavia C. F. Dos Santos, Alessandra S. Padilha, Maiara Krause, Maria Tereza W. D. Carneiro, Leandro Miranda‐Alves, Jones B. Graceli
Cadmium (Cd) is a heavy metal that acts as endocrine disrupting chemical (EDC). Few studies have investigated the effects of Cd exposure on metabolic dysfunctions, such as type 1 and 2 diabetes mellitus (T1DM and T2DM). Thus, we assessed whether subacute Cd exposure at occupational levels causes abnormalities in white adipose tissue (WAT), liver, pancreas, and skeletal muscle. We administered cadmium
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Repair effect of human umbilical cord mesenchymal stem cell‐derived small extracellular vesicles on ovarian injury induced by cisplatin Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-06 Bianling Xu, Wei Guo, Xiaojing He, Zijie Fu, Hongxu Chen, Jun Li, Qingya Ma, Shengjun An, Xiaodong Li
Small extracellular vesicles (sEVs) secreted by human umbilical cord have therapeutic effects on various degenerative diseases. However, the characteristics and potential functions of human umbilical cord mesenchymal stem cells (huMSCs)‐derived sEVs, especially the role of premature ovarian failure (POF), are poorly understood. Here, we isolated and characterized huMSCs and their sEVs. huMSCs highly
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Using single‐cell RNA sequencing and bulk RNA sequencing data to reveal a correlation between smoking and neutrophil activation in esophageal carcinoma patients Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-03 Yunhuan Ba, Xinyu Gu
BackgroundCigarette smoking is considered as a major risk factor for esophageal carcinoma (ESCA) patients. Neutrophil activation plays a key role in cancer development and progression. However, the relationship between cigarette smoking and neutrophils in ESCA patients remained unclear.MethodsSingle‐cell RNA sequencing (scRNA‐seq) and bulk RNA sequencing data were obtained from public databases. Uniform
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Glycyrrhizic acid attenuates the malignant biological properties of nonalcoholic fatty liver disease‐related hepatocellular carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-03 Xueqing Huang, Dengwei You, Tianzhi An, Xuya Zhao, Tianpeng Jiang, Zhi Huang
Glycyrrhizic acid (GA) has effects on anti‐hepatic fibrosis, anti‐tumor and prevention from hepatocellular carcinoma (HCC) progression. Yet, the capacity of GA to ameliorate the advance of HCC pertinent to nonalcoholic fatty liver disease (NAFLD) remains to be clarified. We used the CCK‐8 method to detect the optimal treatment concentration and time for L‐02 cells, palmitic acid (PA)‐induced L‐02 cells
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M1 polarization induction by lead and amyloid peptides in microglial cells: Implications for neurodegeneration process Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-03 Murumulla Lokesh, Lakshmi Jaya Madhuri Bandaru, Ajumeera Rajanna, Virendra Singh Dhayal, Suresh Challa
Neurodegeneration in conditions like Alzheimer's and Parkinson's disease is influenced by genetic and environmental factors. This study explores the potential neurodegenerative effects of lead (Pb) toxicity and amyloid beta peptides (Aβp 1–40 and Aβp 25–35) by promoting M1 polarization in microglial cells. To this end, we investigated and observed that IC50 concentrations of Pb (22.8 μM) and Aβp 25–35(29
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Impact of anesthesia‐related genes on prognosis and tumor microenvironment in hepatocellular carcinoma: A comprehensive analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-05-03 Xia Xu, Lihong Hu
Hepatocellular carcinoma (HCC), renowned for its bleak prognosis and high recurrence rates, necessitates innovative strategies for prognosis assessment and therapeutic intervention. In this pursuit, we systematically investigated the influence of anesthesia‐related genes (ANARGs) on HCC outcomes. Leveraging data from The Cancer Genome Atlas (TCGA), our study scrutinized RNA sequencing data and clinical
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A prognostic model for hepatocellular carcinoma patients based on polyunsaturated fatty acid‐related genes Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-29 Yun Lin, Ruihao Li, Tong Li, Wenrong Zhao, Qianling Ye, Chunyan Dong, Yong Gao
ObjectivePolyunsaturated fatty acids (PUFAs) have attracted increasing attention for their role in liver cancer development. The objective of this study is to develop a prognosis prediction model for patients with liver cancer based on PUFA‐related metabolic gene characteristics.MethodTranscriptome data and clinical data were obtained from public databases, while gene sets related to PUFAs were acquired
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Construction and evaluation of a metabolic correlation diagnostic model for diabetes based on machine learning algorithms Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-29 Qiong Xu, Yina Zhou, Jianfen Lou, Yanhua Fu, Yunzhu Lu, Mengli Xu
BackgroundDiabetes mellitus (DM) is a prevalent chronic disease marked by significant metabolic dysfunctions. Understanding its molecular mechanisms is vital for early diagnosis and treatment strategies.MethodsWe used datasets GSE7014, GSE25724, and GSE156248 from the GEO database to build a diagnostic model for DM using Random Forest (RF) and LASSO regression models. GSE20966 served as a validation
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Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-29 Yijia Shao, Cong Liu, Xiuqi Wang, Wei Zhou
BackgroundObservational studies have indicated that peripheral blood eosinophil count is elevated in individuals diagnosed with ulcerative colitis (UC) and correlates with the disease activity of UC. However, this conclusion contradicts with findings from other studies. Therefore, we employed Mendelian randomization (MR) method to assess the genetic link between eosinophil count and UC.MethodThis MR
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Gallic acid‐loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease‐1 in triple‐negative breast cancer cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-26 Monica Velaiyan, Rajasekar Muthusamy, Miguel Kativa, Asaikkutti Annamalai, Annamalai Govindhan, Parthipan Punniyakotti, Agilan Balupillai
This study investigated the fabrication of gallic acid‐loaded chitosan nanoparticles (Gal‐Chi‐NPs) that enhanced the DNA damage and apoptotic features by inhibiting FEN‐1 expressions in MDA‐MB 231 cells. Gal‐Chi‐NPs were fabricated by the ionic gelation method, and it was characterized by several studies such as dynamic light spectroscopy, Fourier‐transforms infrared spectroscopy, x‐ray diffraction
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STUB1 promotes the degradation of HSPB1 and induces ferroptosis in lung cancer cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-25 Aishanjiang Tieliwaerdi, Abudu Aini, Mulatijiang Amuti, Yiliyaer Aierken, Maimaitijiang Nijiati, Bo Luo
Lung cancer is a common malignancy characterized by ferroptosis, an iron‐dependent form of cell death caused by excessive lipid peroxidation. The disruption of the ubiquitination system plays a crucial role in tumor development and spread. In recent years, there has been increasing interest in utilizing ferroptosis for lung cancer treatment; however, the precise mechanism of how ubiquitination modulates
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Ototoxicity among cisplatin, carboplatin, and oxaliplatin in zebrafish model Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-25 Kuan‐Hui Li, Yi‐Yu Zhao, Hsin‐Lin Cheng, Jiann‐Jou Yang, Chen‐Yu Chien
Platinum‐based antineoplastic drugs, including cisplatin, carboplatin, and oxaliplatin, are widely used in the treatment of various cancers. Ototoxicity is a common adverse effect of platinum‐based drugs. Ototoxicity leads to irreversible hearing impairment. We hypothesize that different platinum‐based drugs exhibit varying ototoxic concentrations, time effects, and ototoxic mechanisms. We tested this
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Erratum of “PLS3 promotes papillary thyroid carcinoma progression by activating the Notch signaling pathway” Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-25
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Tricetin suppresses the cell migration and BMP‐6 expression through p38 signaling pathways in human retinal pigment epithelium cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-24 Hsiang‐Wen Chien, Chih‐Chun Chuang, Yi‐Hsien Hsieh, Chia‐Yi Lee, Nuo‐Yi Yu, Shun‐Fa Yang
Proliferative vitreoretinopathy (PVR) is a visual‐threatening disease, which cause from the migration of retinal pigment epithelium (RPE). Tricetin, a family of flavonoids, can inhibit the metastasis of several cancers. Herein, we aim to evaluate the possible effect of tricetin on inhibiting ARPE‐19 cells migration. The Boyden chamber assay, wound healing assay, RNA sequencing, and Western blot analysis
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Luteolin, apigenin, and chrysin inhibit lipotoxicity–induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-24 Chia‐Wen Lo, Chong‐Kuei Lii, Kuan‐Shuan Lin, Chien‐Chun Li, Kai‐Li Liu, Ya‐Chen Yang, Haw‐Wen Chen
Lipotoxicity leads to numerous metabolic disorders such as nonalcoholic steatohepatitis. Luteolin, apigenin, and chrysin are three flavones with known antioxidant and anti‐inflammatory properties, but whether they inhibit lipotoxicity‐mediated NLRP3 inflammasome activation was unclear. To address this question, we used J774A.1 macrophages and Kupffer cells stimulated with 100 μM palmitate (PA) in the
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Betaine ameliorates doxorubicin‐induced cardiomyopathy by inhibiting oxidative stress, inflammation, and fibrosis through the modulation of AMPK/Nrf2/TGF‐β expression Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-23 Sumeet Kumar Singh, Poonam Yadav, Dhaneshvaree Patel, Sampat Singh Tanwar, Abhishek Sherawat, Amit Khurana, Jasvinder Singh Bhatti, Umashanker Navik
Doxorubicin (DOX) is a broad‐spectrum antibiotic with potent anti‐cancer activity. Nevertheless, despite having effective anti‐neoplasm activity, its use has been clinically restricted due to its life‐threatening side effects, such as cardiotoxicity. It is evident that betaine has anti‐oxidant, and anti‐inflammatory activity and has several beneficial effects, such as decreasing the amyloid‐β generation
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Cadmium aggravates liver injury by activating ferroptosis and neutrophil extracellular traps formation in Nile tilapia (Oreochromis niloticus) Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-22 Jingjing Wang, Yichun Chen, Xia Wang, Youpeng Sun, Mingzhen Jiang, Yingrong Ye, Hanpeng Wu, Yun Lu, Huabing Zhong, Yihe Wu, Ershun Zhou, Zhengtao Yang
Cadmium (Cd) is a pervasive environmental contaminant and a significant risk factor for liver injury. The present study was undertaken to evaluate the involvement of ferroptosis and neutrophil extracellular traps (NETs) in Cd‐induced liver injury in Nile tilapia (Oreochromis niloticus), and to explore its underlying mechanism. Cd‐induced liver injury was associated with increased total iron, malondialdehyde
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High expression of AlkB homolog 5 suppresses the progression of non‐small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11 Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-20 Zhangzhou Huang, Gen Lin, Yaping Hong, Lihong Weng, Kai Zhu, Wu Zhuang
ObjectiveNon‐small cell lung cancer (NSCLC) is a prevailing LC characterized by poor outcomes. AlkB homolog 5 (ALKBH5) functions as a tumor suppressor in several cancers. This study delved into the role of ALKBH5 in NSCLC development.MethodsTCGA database predicted ALKBH5 expression in NSCLC patients. ALKBH5 levels in NSCLC and human bronchial epithelial cells were determined. pcDNA3.1‐ALKBH5/NC, pcDNA3
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Diallyl disulfide antagonizes DJ‐1 mediated proliferation, epithelial–mesenchymal transition, and chemoresistance in gastric cancer cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-20 Jian Su, Hong Xia, Hui He, Huan Tang, Juan Zhou, Yi Xun, Fang Liu, Bo Su, Qi Su
Diallyl disulfide (DADS), an organic component of allicin abstracted from garlic, possesses multi‐target antitumor activity. DJ‐1 performs a vital function in promoting AKT aberrant activation via down‐regulating phosphatase and tensin homologue (PTEN) in tumors. It is unknown the involvement of DJ‐1 in epithelial–mesenchymal transition (EMT) of gastric cancer (GC) cells. The purpose of this study
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Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV‐related hepatocellular carcinoma risk: A system review and meta‐analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-18 Xiaofeng Dong, Mengjie Zou, Chunxing Li, Honglin Luo, Shaoliang Zhu, Zheng Gong
Increasing evidence has suggested a strong association of hepatocellular carcinoma (HCC) susceptibility and Gln223Arg (rs1137101) and Lys109Arg (rs1137100) polymorphisms in leptin receptor (LEPR) genes. To provide a quantitative assessment for such correlation, we reviewed all related systems and conducted meta‐analysis for case and control researches. A literature search of Web of Science, EMBASE
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Critical role of endoplasmic reticulum stress on bisphenol A‐induced cytotoxicity in human keratinocyte HaCaT cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-17 Sou Hyun Kim, Dong Wan Kang, Doyoung Kwon, Young‐Suk Jung
Bisphenol A (BPA) is widely used in plastic and paper products, and its exposure can occur through skin contact or oral ingestion. The hazardous effects of BPA absorbed through the skin may be more severe; however, few studies have investigated the skin toxicity of BPA. This study investigated the effects of BPA on human epidermal keratinocyte cell lines, which is relevant for skin exposure. BPA treatment
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Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Huayan Ma, Yuxian Zhang, Jing Li, Tiantian Xie, Zhi Zhao
Osteosarcoma is a highly aggressive cancer prevalent among adolescents and young adults, notorious for its tendency to metastasize to the lungs. This research delves into the molecular foundations of osteosarcoma by examining the role of the Hippo signaling pathway and its interaction with the tumor immune microenvironment (TME). Through analysis of transcriptomic data from the TARGET‐OS dataset and
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Single‐cell and bulk RNA‐sequencing reveal SPP1 and CXCL12 as cell‐to‐cell communication markers to predict prognosis in lung adenocarcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Zengtuan Xiao, Zhe Nian, Mengzhe Zhang, Zuo Liu, Pengpeng Zhang, Zhenfa Zhang
Lung adenocarcinoma (LUAD) generally presents as an immunosuppressive microenvironment. The characteristics of cell‐to‐cell communication in the LUAD microenvironment has been unclear. In this study, the LUAD bulk RNA‐seq data and single‐cell RNA‐seq data were retrieved from public dataset. Differential expression genes (DEGs) between LUAD tumor and adjacent non‐tumor tissues were calculated by limma
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Teaghrelin protected dopaminergic neurons in MPTP‐induced Parkinson's disease animal model by promoting PINK1/Parkin‐mediated mitophagy and AMPK/SIRT1/PGC1‐α‐mediated mitochondrial biogenesis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Cian‐Fen Jhuo, Chun‐Jung Chen, Jason T.C. Tzen, Wen‐Ying Chen
Mitochondrial dysfunction, a common cellular hallmark in both familial and sporadic forms of Parkinson's disease (PD), is assumed to play a significant role in pathologic development and progression of the disease. Teaghrelin, a unique bioactive compound in some oolong tea varieties, has been demonstrated to protect SH‐SY5Y cells against 1‐methyl‐4‐phenylpyridinium induced neurotoxicity by binding
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Deciphering programmed cell death mechanisms in osteosarcoma for prognostic modeling Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Jingyang Chen, Tengdi Fan, Lingxiao Pan, Hanshi Yang
Osteosarcoma (OS), known for its high recurrence and metastasis rates, poses a significant challenge in oncology. Our research investigates the role of programmed cell death (PCD) genes in OS and develops a prognostic model using advanced bioinformatics. We analyzed single‐cell sequencing data from the Gene Expression Omnibus (GEO) database to identify subpopulations, distinguish malignant from non‐malignant
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Comprehensive analysis of lung adenocarcinoma: Unveiling differential gene expression, survival‐linked genes, subtype stratification, and immune landscape implications Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-15 Yong Xi, Liu Xi, Jian Tan, Chaoqun Yu, Weiyu Shen, Bentong Yu
This study offers a detailed exploration of lung adenocarcinoma (LUAD), addressing its heterogeneity and treatment challenges through a multi‐faceted analysis that includes gene expression, genetic subtyping, pathway analysis, immune assessment, and drug sensitivity. It identifies 165 genes with significant expression differences and 46 genes associated with survival, revealing insights into oxidative
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Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-13 Jen‐Ning Tsai, Yun‐Hsin Wang, Po‐Ju Lin, Chiung‐Fang Chang, Chiao‐Yin Sun, Yau‐Hung Chen
Coriander is a notable medicinal plant known for its diverse properties, including anti‐inflammatory, antioxidant, anticancer, analgesic, and anti‐diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic
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Voacangine mitigates oxidative stress and neuroinflammation in middle cerebral artery occlusion‐induced cerebral ischemia/reperfusion injury by averting the NF‐κBp65/MAPK signaling pathways in rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Bo Xu, Hua Wu, Wei Guo, Shaik Althaf Hussain, Tian Wang
Ischemic stroke is a leading cause of human mortality. Cerebral ischemia–reperfusion injury (CI/RI) is a primary cause of stroke. Ischemia–reperfusion (I/R) resulting in oxidative stress and inflammatory events may lead to severe neuronal impairments. Thus, anti‐oxidative and anti‐inflammatory mediators that can alleviate post‐I/R neuronal injuries are required for the treatment of CI/RI. An alkaloid
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Potato protein hydrolysate inhibits RANKL‐induced osteoclast development by inhibiting osteoclastogenic genes via the NF‐κB/MAPKs signaling pathways Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Yi‐Ju Chen, Yen‐Hua He, Yun‐Hsin Lo, Hong‐Siang Yang, Mosleh Mohammad Abomughaid, K. J. Senthil Kumar, Wan‐Teng Lin
In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti‐osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor‐κB ligand (RANKL)
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A prognostic model established using bile acid genes to predict the immunity and survival of patients with gastrointestinal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Xin Wu, Peifa Liu, Qing Wang, Linde Sun, Yu Wang
BackgroundThe metabolism of abnormal bile acids (BAs) is implicated in the initiation and development of gastrointestinal (GI) cancer. However, there was a lack of research on the molecular mechanisms of BAs metabolism in GI.MethodsGenes involved in BAs metabolism were excavated from public databases of The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, and Molecular Signatures
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The immune landscape and prognostic analysis of CXCL8 immune‐related genes in cervical squamous cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Xiaoqian Zhang, Jian Yang, Qianqian Feng, Liping Gu, Gongzhao Qin, Chen Cheng, Shunyu Hou, Zhouhong Shi
Cervical squamous cell carcinoma (CESC), one of the most common malignancies in women, imposes a significant burden on women's health worldwide. Despite extensive research, the molecular and pathogenic mechanisms of cervical squamous cell carcinoma and CESC remain unclear. This study aimed to explore the immune‐related genes, immune microenvironment infiltration, and prognosis of CESC, providing a
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Role of formyl peptide receptor 2 in steatosis of L02 cells exposed to Mono‐(2‐ethylhexyl) phthalate Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Xuemin Feng, Ruxuan Zhang, Xiaohan Miao, Xu Li, Jianwei Cui, Hang Xu, Xiaoqi Fang, Chunkui Zhou, Lin Ye, Liting Zhou
Mono‐(2‐ethylhexyl) phthalate (MEHP) can accumulate in the liver and then lead to hepatic steatosis, while the underlying mechanism remains unclear. Inflammation plays an important role in the disorder of hepatic lipid metabolism. This study aims to clarify the role of the inflammatory response mediated by formyl peptide receptor 2 (FPR2) in steatosis of L02 cells exposed to MEHP. L02 cells were exposed
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Interleukin‐4 inhibits the hypothalamic appetite control by modulating the insulin‐AKT and JAK‐STAT signaling in leptin mutant mice Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Shu‐Mei Chen, Chiao‐Wan Hsiao, Yen‐Ju Chen, Chen‐Jee Hong, Jung‐Chun Lin, Ching‐Ping Yang, Yih‐Hsin Chang
Our previous research identified interleukin‐4 (IL‐4) as a key regulator of glucose/lipid metabolism, circulatory leptin levels, and insulin action, suggesting its potential as a therapeutic target for obesity and related complications. This study aimed to further elucidate the role of IL‐4 in regulating hypothalamic appetite‐controlling neuropeptides using leptin dysfunctional Leptin145E/145E mice
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Zinc finger Protein207 orchestrates glioma migration through regulation of epithelial‐mesenchymal transition Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Chao Zhao, Yuduo Guo, Yujia Chen, Guanjie Shang, Dixiang Song, Jun Wang, Jingjing Yang, Hongwei Zhang
BackgroundGlioma represents the predominant primary malignant brain tumor. For several years, molecular profiling has been instrumental in the management and therapeutic stratification of glioma, providing a deeper understanding of its biological complexity. Accumulating evidence unveils the putative involvement of zinc finger proteins (ZNFs) in cancer. This study aimed to elucidate the role and significance
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Research on the toxicological prognostic significance of age‐related genes in endometrial cancer unveiling key factors in patient prognosis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Yongchao Yin, Qian Niu, Zhiqiang Wei, Yefei Wang, Gang Li, Weican Zhang, Kai Guo, Xinyu Yao
This study investigates the influence of aging‐related genes on endometrial cancer, a prominent gynecological malignancy with rising incidence and mortality. By analyzing gene expression differences between cancerous and normal endometrial tissues, 42 aging‐related genes were identified as differentially expressed. Utilizing the TCGA‐UCEC sample, consensus clustering divided the samples into two molecular
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Advancing predictive markers in lung adenocarcinoma: A machine learning‐based immunotherapy prognostic prediction signature Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Zhongyan Li, Shengbin Pei, Yanjuan Wang, Ge Zhang, Haoran Lin, Shiyang Dong
The prognosis of lung adenocarcinoma (LUAD) is generally poor. Immunotherapy has emerged as a promising therapeutic modality, demonstrating remarkable potential for substantially prolonging the overall survival of individuals afflicted with LUAD. However, there is currently a lack of reliable signatures for identifying patients who would benefit from immunotherapy. We conducted a comparative analysis
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miR‐29b‐3p targetedly regulates VEGF to inhibit tumor progression and cisplatin resistance through Nrf2/HO‐1 signaling pathway in non‐small cell lung cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-08 Zhen Sun, Mingming Ren, Jieting Niu, Guojie Tang, Yanguang Li, Fanyi Kong, Xiang Song
BackgroundsNon‐small cell lung carcinoma (NSCLC) is a common type of lung cancer. Prior investigations have elucidated the pivotal role of miR‐29b‐3p in restraining tumor growth and metastasis. Nonetheless, it remains to be determined whether miR‐29b‐3p can effectively suppress NSCLC progression and enhance the sensitivity of NSCLC cells to cisplatin. This investigation sought to determine the mechanism
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PTPN7 mediates macrophage‐polarization and determines immunotherapy in gliomas: A single‐cell sequencing analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Xiang Ji, Jingsong Cheng, Jing Su, Rong Wen, Qi Zhang, Guodong Liu, Yun Peng, Jinning Mao
BackgroundProtein tyrosine phosphatase non‐receptor type 7 (PTPN7) is a signaling molecule that regulates a multitude of cellular processes, spanning cell proliferation, cellular differentiation, the mitotic cycle, and oncogenic metamorphosis. However, the characteristic of PTPN7 in the glioma microenvironment has yet to be elucidated.MethodsThe prognostic value, genomic features, immune characteristics
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Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Kaede Namba, Takashi Tominaga, Yasuhiro Ishihara
Neonicotinoids are insecticides widely used in the world. Although neonicotinoids are believed to be toxic only to insects, their developmental neurotoxicity in mammals is a concern. Therefore, we examined the effects of developmental exposure to neonicotinoids on immune system in the brain and post‐developmental behaviors in this study. Imidacloprid or clothianidin was orally administered to dams
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Integrative analysis of the bladder cancer from a cell cycle NCAM1 perspective at both single cell and bulk resolution Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Xiangju Zeng, Hao Su, Ziqi Liu, Yinhuai Wang, Zhijie Lu, Shunhua Cheng
IntroductionBladder cancer (BLCA) is a prevalent and deadly form of urinary cancer, and there is a need for effective therapies, particularly for muscle‐invasive bladder cancer (MIBC). Cell cycle inhibitors show promise in restoring control of the cell cycle in BLCA cells, but their clinical prognosis evaluation is limited.MethodsTranscriptome and scRNA‐seq data were collected from the Cancer Genome
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Identification of potential therapeutic targets for breast cancer using Mendelian randomization analysis and drug target prediction Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Zhulan Huang, Hongping Zheng, Haiyu Wang, Haojie Ning, Aiwen Che, Cuidan Cai
Breast cancer stands as the foremost cause of cancer‐related mortality among women, presenting a substantial economic impact on society. The limitations in current therapeutic options, coupled with poor patient tolerance, underscore the urgent need for novel treatments. Our study embarked on a genomic association exploration of breast cancer, leveraging whole‐genome sequencing data from the Finngen
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RNA modification‐related EIF4G2 is an immunotherapy determinant in osteosarcoma: A single‐cell sequencing analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-05 Haocheng Qin, Shu Yang, Zhennan Feng, Song Wu, Ting Cai, Zijing Xie, Hai Hu
The clinical outcomes of osteosarcoma are relatively dismal. As immunotherapy has revolutionized treatment for solid tumors, exploring novel immunotherapy‐related therapeutic targets for osteosarcoma is important. In this study, we aimed to establish the connection between RNA modification and immunotherapy in osteosarcoma to identify novel therapeutic targets. An RNA modification‐related signature
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Single‐cell transcriptome sequencing analysis reveals intra‐tumor heterogeneity in esophageal squamous cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Yuanliu Nie, Guangyue Yao, Yanjun Wei, Sheng Wu, Wentao Zhang, Xiaoying Xu, Qiang Li, Fengge Zhou, Zhe Yang
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive system that poses a significant threat to human life and health. It is crucial to thoroughly investigate the mechanisms of esophageal carcinogenesis and identify potential key molecular events in its carcinogenesis. Single‐cell transcriptome sequencing is an emerging technology that has gained prominence in recent
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Globular adiponectin induces esophageal adenocarcinoma cell pyroptosis via the miR‐378a‐3p/UHRF1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Jun Wang, Yan Cheng, Yin Xiaoran, Fengrong Chen, Wu Jie, Huang Yahui, Wang Yue, Liu Dong, Luo Yumei, Feng Cheng, Zhang Libo, Zhang Jun
BackgroundAntiapoptosis is a major factor in the resistance of tumor cells to chemotherapy and radiotherapy. Thus, activation of cell pyroptosis may be an effective option to deal with antiapoptotic cancers such as esophageal adenocarcinoma (EAC).MethodsDifferential expression of ubiquitin‐like versus PHD and ring finger structural domain 1 (UHRF1) in EAC and near normal tissues was analyzed, as well
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How renal toxins respond to renal function deterioration and oral toxic adsorbent in pH‐controlled releasing capsule Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Wen‐Sheng Liu, Shih‐Shin Liang, Mei‐Mei Cheng, Ming‐Tsan Wu, Szu‐Yuan Li, Tien‐Tien Cheng, Tsung‐Yun Liu, Ching‐Yao Tsai, Yen‐Ting Lai, Chien‐Hung Lin, Hsiang‐Tsui Wang, Han‐Hsing Tsou
The number of patients with chronic kidney disease (CKD) is increasing. Oral toxin adsorbents may provide some value. Several uremic toxins, including indoxyl sulfate (IS), p‐cresol (PCS), acrolein, per‐ and poly‐fluoroalkyl substances (PFAS), and inflammation markers (interleukin 6 [IL‐6] and tumor necrosis factor [TNF]‐alpha) have been shown to be related to CKD progression. A total of 81 patients
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Mitochondria‐associated endoplasmic reticulum membranes involve in oxidative stress‐induced intestinal barrier injury and mitochondrial dysfunction under diquat exposing Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Feiyang Gou, Fengzhou Cai, Xin Li, Qian Lin, Jiang Zhu, Minjie Yu, Shaokui Chen, Jianjun Lu, Caihong Hu
Many factors induced by environmental toxicants have made oxidative stress a risk factor for the intestinal barrier injury and growth restriction, which is serious health threat for human and livestock and induces significant economic loss. It is well‐known that diquat‐induced oxidative stress is implicated in the intestinal barrier injury. Although some studies have shown that mitochondria are the
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Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Tingting Guo, Yuhang He, Shengqiang Mao, Ying Yang, Hongguan Xie, Sifan Zhang, Shuiping Dai
Although the stimulative effects on the normal behaviors of fish posed by ketamine (KET) were well‐studied, the adverse effects on the behavioral functions induced by KET at nighttime were unknown. Here, we used zebrafish larvae as a model exposed to KET (10, 50, 100, and 250 ng/L) at environmental levels for 21 days. The behavioral functions at nighttime, morphological changes during exposure stage
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Asiatic acid inhibits osteosarcoma cell migration and invasion via the AKT/Sp1/MMP1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Yat‐Yin Law, Hsiang‐Lin Lee, Chu‐Liang Lin, Pei‐Ni Chen, Pei‐Han Wang, Yi‐Hsien Hsieh, Chien‐Min Chen
Osteosarcoma is a malignant bone tumor affecting adolescents and children. No effective treatment is currently available. Asiatic acid (AA), a triterpenoid compound found in Centella asiatica, possesses anti‐tumor, anti‐inflammatory, and anti‐oxidant properties in various types of tumor cells. This study aims to determine whether AA exerts antitumor effects in human osteosarcoma cells. Our results
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Correction to “The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats.” Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03
Valokola MG, Karimi G, Razavi BM, et al. The protective activity of nanomicelle curcumin in bisphenol A-induced cardiotoxicity following subacute exposure in rats. Environ Toxicol. 2019; 34: 319–329. https://doi.org/10.1002/tox.22687 In paragraph 2 of the “Materials and Methods” section, the text, “Each group consisted of 6 rats.” was incorrect. This should have read: “Each group consisted of 4-8 rats