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Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase Nat. Chem. (IF 21.8) Pub Date : 2024-05-14 Basavraj Khanppnavar, Joel P. S. Choo, Peter-Leon Hagedoorn, Grigory Smolentsev, Saša Štefanić, Selvapravin Kumaran, Dirk Tischler, Fritz K. Winkler, Volodymyr M. Korkhov, Zhi Li, Richard A. Kammerer, Xiaodan Li
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Enabling nucleophilic reactivity in molecular calcium fluoride complexes Nat. Chem. (IF 21.8) Pub Date : 2024-05-14 Job J. C. Struijs, Mathias A. Ellwanger, Agamemnon E. Crumpton, Véronique Gouverneur, Simon Aldridge
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A lithium–aluminium heterobimetallic dimetallocene Nat. Chem. (IF 21.8) Pub Date : 2024-05-14 Inga-Alexandra Bischoff, Sergi Danés, Philipp Thoni, Bernd Morgenstern, Diego M. Andrada, Carsten Müller, Jessica Lambert, Elias C. J. Gießelmann, Michael Zimmer, André Schäfer
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Deciding the future of adipic acid Nat. Chem. (IF 21.8) Pub Date : 2024-05-08 John F. C. Steele, Stephen Wallace
John Steele and Stephen Wallace discuss recent advances in the chemical and biotechnological synthesis of the prolific platform chemical adipic acid.
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Enantioselective construction of stereogenic-at-sulfur(IV) centres via catalytic acyl transfer sulfinylation Nat. Chem. (IF 21.8) Pub Date : 2024-05-08 Tao Wei, Han-Le Wang, Yin Tian, Ming-Sheng Xie, Hai-Ming Guo
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Modular chemoenzymatic synthesis of ten fusicoccane diterpenoids Nat. Chem. (IF 21.8) Pub Date : 2024-05-06 Yanlong Jiang, Hans Renata
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A tetrahedral neptunium(V) complex Nat. Chem. (IF 21.8) Pub Date : 2024-05-06 Julie E. Niklas, Kaitlyn S. Otte, Chad M. Studvick, Sabyasachi Roy Chowdhury, Bess Vlaisavljevich, John Bacsa, Florian Kleemiss, Ivan A. Popov, Henry S. La Pierre
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Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed proteins Nat. Chem. (IF 21.8) Pub Date : 2024-05-03 J. David Schnettler, Michael S. Wang, Maximilian Gantz, H. Adrian Bunzel, Christina Karas, Florian Hollfelder, Michael H. Hecht
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Dynamic two-dimensional covalent organic frameworks Nat. Chem. (IF 21.8) Pub Date : 2024-05-03 Florian Auras, Laura Ascherl, Volodymyr Bon, Simon M. Vornholt, Simon Krause, Markus Döblinger, Derya Bessinger, Stephan Reuter, Karena W. Chapman, Stefan Kaskel, Richard H. Friend, Thomas Bein
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Persistent organonickel complexes as general platforms for Csp2–Csp3 coupling reactions Nat. Chem. (IF 21.8) Pub Date : 2024-04-29 Long P. Dinh, Hunter F. Starbuck, Taylor B. Hamby, Matthew J. LaLama, Cyndi Q. He, Dipannita Kalyani, Christo S. Sevov
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Dynamic crystal structure of a molecular framework Nat. Chem. (IF 21.8) Pub Date : 2024-04-26 Lauren E. Hatcher, Paul R. Raithby
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Precision synthesis and closed-loop recycling of ultrahigh-molar-mass cyclic polymers Nat. Chem. (IF 21.8) Pub Date : 2024-04-26
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The search for Europan life Nat. Chem. (IF 21.8) Pub Date : 2024-04-26 Bruce C. Gibb
Excited by the prospect of future missions to the Jupiter system, Bruce Gibb explores the chemistry of Jupiter’s moons and wonders whether there could be life on Europa.
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Formylation boosts the performance of light-driven overcrowded alkene-derived rotary molecular motors Nat. Chem. (IF 21.8) Pub Date : 2024-04-26 Jinyu Sheng, Wojciech Danowski, Andy S. Sardjan, Jiaxin Hou, Stefano Crespi, Alexander Ryabchun, Maximilian Paradiz Domínguez, Wybren Jan Buma, Wesley R. Browne, Ben L. Feringa
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Constructing artificial gap junctions to mediate intercellular signal and mass transport Nat. Chem. (IF 21.8) Pub Date : 2024-04-24 Yong-Hong Fu, Yi-Fei Hu, Tao Lin, Guo-Wei Zhuang, Ying-Lan Wang, Wen-Xue Chen, Zhan-Ting Li, Jun-Li Hou
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Designer peptide–DNA cytoskeletons regulate the function of synthetic cells Nat. Chem. (IF 21.8) Pub Date : 2024-04-23 Margaret L. Daly, Kengo Nishi, Stephen J. Klawa, Kameryn Y. Hinton, Yuan Gao, Ronit Freeman
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Mechanical scission of a knotted polymer Nat. Chem. (IF 21.8) Pub Date : 2024-04-22 Min Zhang, Robert Nixon, Fredrik Schaufelberger, Lucian Pirvu, Guillaume De Bo, David A. Leigh
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Proton-triggered topological transformation in superbase-mediated selective polymerization enables access to ultrahigh-molar-mass cyclic polymers Nat. Chem. (IF 21.8) Pub Date : 2024-04-22 Li Zhou, Liam T. Reilly, Changxia Shi, Ethan C. Quinn, Eugene Y.-X. Chen
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Upcycling chlorinated trash into synthetic organic treasure Nat. Chem. (IF 21.8) Pub Date : 2024-04-19 Andrew Jordan
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Assembling the pieces to improve catalysis Nat. Chem. (IF 21.8) Pub Date : 2024-04-19 Ana Sonea, Jeffrey J. Warren
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Deprotonated 2-thiolimidazole serves as a metal-free electrocatalyst for selective acetylene hydrogenation Nat. Chem. (IF 21.8) Pub Date : 2024-04-19 Lei Zhang, Rui Bai, Jin Lin, Jun Bu, Zhenpeng Liu, Siying An, Zhihong Wei, Jian Zhang
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Organic solvent enhances oxidative folding of disulfide-rich proteins Nat. Chem. (IF 21.8) Pub Date : 2024-04-18 Shay Laps, Norman Metanis
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A para- to meta-isomerization of phenols Nat. Chem. (IF 21.8) Pub Date : 2024-04-17 Simon Edelmann, Jean-Philip Lumb
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Stereoretentive enantioconvergent reactions Nat. Chem. (IF 21.8) Pub Date : 2024-04-17 Steven H. Bennett, Jacob S. Bestwick, Vera P. Demertzidou, David J. Jones, Helen E. Jones, François Richard, Joshua A. Homer, Rosie Street-Jeakings, Andrew F. Tiberia, Andrew L. Lawrence
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Stereodivergent photobiocatalytic radical cyclization through the repurposing and directed evolution of fatty acid photodecarboxylases Nat. Chem. (IF 21.8) Pub Date : 2024-04-17 Shuyun Ju, Dian Li, Binh Khanh Mai, Xin Liu, Alec Vallota-Eastman, Jianping Wu, David L. Valentine, Peng Liu, Yang Yang
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Mechanically triggered on-demand degradation of polymers synthesized by radical polymerizations Nat. Chem. (IF 21.8) Pub Date : 2024-04-12 Peng Liu, Sètuhn Jimaja, Stefan Immel, Christoph Thomas, Michael Mayer, Christoph Weder, Nico Bruns
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Bioorthogonal masked acylating agents for proximity-dependent RNA labelling Nat. Chem. (IF 21.8) Pub Date : 2024-04-09 Shubhashree Pani, Tian Qiu, Kaitlin Kentala, Saara-Anne Azizi, Bryan C. Dickinson
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Upcycling of polyethylene to gasoline through a self-supplied hydrogen strategy in a layered self-pillared zeolite Nat. Chem. (IF 21.8) Pub Date : 2024-04-09 Ziyu Cen, Xue Han, Longfei Lin, Sihai Yang, Wanying Han, Weilong Wen, Wenli Yuan, Minghua Dong, Zhiye Ma, Fang Li, Yubin Ke, Juncai Dong, Jin Zhang, Shuhu Liu, Jialiang Li, Qian Li, Ningning Wu, Junfeng Xiang, Hao Wu, Lile Cai, Yanbo Hou, Yongqiang Cheng, Luke L. Daemen, Anibal J. Ramirez-Cuesta, Pilar Ferrer, David C. Grinter, Georg Held, Yueming Liu, Buxing Han
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Copper-catalysed asymmetric hydroboration of alkenes with 1,2-benzazaborines to access chiral naphthalene isosteres Nat. Chem. (IF 21.8) Pub Date : 2024-04-08 Wanlan Su, Jide Zhu, Yu Chen, Xu Zhang, Weihua Qiu, Kai Yang, Peiyuan Yu, Qiuling Song
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Tetrameric self-assembling of water-lean solvents enables carbamate anhydride-based CO2 capture chemistry Nat. Chem. (IF 21.8) Pub Date : 2024-04-08 Julien Leclaire, David J. Heldebrant, Katarzyna Grubel, Jean Septavaux, Marc Hennebelle, Eric Walter, Ying Chen, Jose Leobardo Bañuelos, Difan Zhang, Manh-Thuong Nguyen, Debmalya Ray, Sarah I. Allec, Deepika Malhotra, Wontae Joo, Jaelynne King
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Call me serotonin Nat. Chem. (IF 21.8) Pub Date : 2024-04-05 Cameron S. Movassaghi, Anne Milasincic Andrews
Serotonin is known by many names — in science as 5-hydroxytryptamine (5-HT) or enteramine, and in popular culture as the ‘feel good’ chemical or the ‘happy hormone’. Cameron Movassaghi and Anne Andrews discuss the knowns and unknowns of this well-studied yet elusive neurotransmitter.
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Towards zero droplet friction Nat. Chem. (IF 21.8) Pub Date : 2024-04-05 Abhinav Naga, Doris Vollmer
Surface heterogeneities lead to friction between droplets and solid surfaces, limiting the performance of the latter in a number of applications. A combination of friction force measurements and atomistic molecular dynamics simulations now sheds light on the influence of molecular scale heterogeneities on droplet friction.
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Methylation enables high-voltage ether electrolytes for lithium metal batteries Nat. Chem. (IF 21.8) Pub Date : 2024-04-03
Ether-based electrolytes are desired for lithium metal batteries owing to their low reduction potentials; however, they suffer from low anodic stability. Strategic methylation of ether solvents is shown to extend their electrochemical stability and facilitate the formation of LiF-rich interphases, enabling high-voltage lithium metal batteries while avoiding the use of fluorinated solvents.
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Methylation enables the use of fluorine-free ether electrolytes in high-voltage lithium metal batteries Nat. Chem. (IF 21.8) Pub Date : 2024-04-03 Ai-Min Li, Oleg Borodin, Travis P. Pollard, Weiran Zhang, Nan Zhang, Sha Tan, Fu Chen, Chamithri Jayawardana, Brett L. Lucht, Enyuan Hu, Xiao-Qing Yang, Chunsheng Wang
Lithium metal batteries represent a promising technology for next-generation energy storage, but they still suffer from poor cycle life due to lithium dendrite formation and cathode cracking. Fluorinated solvents can improve battery longevity by improving LiF content in the solid–electrolyte interphase; however, the high cost and environmental concerns of fluorinated solvents limit battery viability
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An air- and moisture-stable ruthenium precatalyst for diverse reactivity Nat. Chem. (IF 21.8) Pub Date : 2024-04-03 Gillian McArthur, Jamie H. Docherty, Mishra Deepak Hareram, Marco Simonetti, Iñigo J. Vitorica-Yrezabal, James J. Douglas, Igor Larrosa
Versatile, efficient and robust (pre)catalysts are pivotal in accelerating the discovery and optimization of chemical reactions, shaping diverse synthetic fields such as cross-coupling, C–H functionalization and polymer chemistry. Yet, their scarcity in certain domains has hindered the advancement and adoption of new applications. Here we present a highly reactive air- and moisture-stable ruthenium
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A directed enolization strategy enables by-product-free construction of contiguous stereocentres en route to complex amino acids Nat. Chem. (IF 21.8) Pub Date : 2024-04-02 Fenglin Hong, Timothy P. Aldhous, Paul D. Kemmitt, John F. Bower
Homochiral α-amino acids are widely used in pharmaceutical design as key subunits in chiral catalyst synthesis or as building blocks in synthetic biology. Many synthetic methods have been developed to access rare or unnatural variants by controlling the installation of the α-stereocentre. By contrast, and despite their importance, α-amino acids possessing β-stereocentres are much harder to synthesize
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Asymmetric photoredox catalytic formal de Mayo reaction enabled by sensitization-initiated electron transfer Nat. Chem. (IF 21.8) Pub Date : 2024-04-02 Xin Sun, Yilin Liu, Yanli Yin, Xu Ban, Xiaowei Zhao, Zhiyong Jiang
Visible-light-driven photoredox catalysis is known to be a powerful tool for organic synthesis. Its occurrence critically depends on the twice exothermic single-electron transfer processes of photosensitizers, which are governed by the redox properties of the species involved. Hence, the inherently narrow range of redox potentials of photosensitizers inevitably constrains their further availability
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Radiotherapy activates picolinium prodrugs in tumours Nat. Chem. (IF 21.8) Pub Date : 2024-04-01 Qunfeng Fu, Zhi Gu, Siyong Shen, Yifei Bai, Xianglin Wang, Mengxin Xu, Pengwei Sun, Junyi Chen, Dongxuan Li, Zhibo Liu
Radiotherapy-induced prodrug activation provides an ideal solution to reduce the systemic toxicity of chemotherapy in cancer therapy, but the scope of the radiation-activated protecting groups is limited. Here we present that the well-established photoinduced electron transfer chemistry may pave the way for developing versatile radiation-removable protecting groups. Using a functional reporter assay
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Expanding the molecular language of protein liquid–liquid phase separation Nat. Chem. (IF 21.8) Pub Date : 2024-03-29 Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S. Schuster, Kristi L. Kiick, Jeetain Mittal
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Lifting iron higher and higher Nat. Chem. (IF 21.8) Pub Date : 2024-03-28 Adam T. Fiedler, Laxmi Devkota
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Bridging the information gap in organic chemical reactions Nat. Chem. (IF 21.8) Pub Date : 2024-03-28 Malte L. Schrader, Felix R. Schäfer, Felix Schäfers, Frank Glorius
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Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion Nat. Chem. (IF 21.8) Pub Date : 2024-03-26 Maria Weyh, Marie-Lena Jokisch, Tuan-Anh Nguyen, Maximilian Fottner, Kathrin Lang
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Blocking and rescuing tryptophan interactions Nat. Chem. (IF 21.8) Pub Date : 2024-03-25 Aidan K. Haney, T. Ashton Cropp
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Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging Nat. Chem. (IF 21.8) Pub Date : 2024-03-25 William E. Meador, Eric Y. Lin, Irene Lim, Hannah C. Friedman, David Ndaleh, Abdul K. Shaik, Nathan I. Hammer, Boqian Yang, Justin R. Caram, Ellen M. Sletten, Jared H. Delcamp
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Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water Nat. Chem. (IF 21.8) Pub Date : 2024-03-25 Isaac N. Cloward, Tianfei Liu, Jamie Rose, Tamara Jurado, Annabell G. Bonn, Matthew B. Chambers, Catherine L. Pitman, Marc A. ter Horst, Alexander J. M. Miller
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Dynamic three-dimensional structures of a metal–organic framework captured with femtosecond serial crystallography Nat. Chem. (IF 21.8) Pub Date : 2024-03-25 Jaedong Kang, Yunbeom Lee, Seonggon Lee, Hosung Ki, Jungmin Kim, Jain Gu, Yongjun Cha, Jun Heo, Kyung Won Lee, Seong Ok Kim, Jaehyun Park, Sang-Youn Park, Sangsoo Kim, Rory Ma, Intae Eom, Minseok Kim, Jeongho Kim, Jae Hyuk Lee, Hyotcherl Ihee
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Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides Nat. Chem. (IF 21.8) Pub Date : 2024-03-25 Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R. Dommaraju, Haiyang Cui, Maolin Li, Mayuresh G. Gadgil, Douglas A. Mitchell, Huimin Zhao
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Identifying phase-separating biomolecular condensates in cells Nat. Chem. (IF 21.8) Pub Date : 2024-03-22
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Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles Nat. Chem. (IF 21.8) Pub Date : 2024-03-19 Zheng Zhang, Ying Sun, Yi Gong, Da-Liang Tang, Hui Luo, Zhi-Peng Zhao, Feng Zhou, Xin Wang, Jian Zhou
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Cage escape governs photoredox reaction rates and quantum yields Nat. Chem. (IF 21.8) Pub Date : 2024-03-18 Cui Wang, Han Li, Tobias H. Bürgin, Oliver S. Wenger
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High-throughput and proteome-wide discovery of endogenous biomolecular condensates Nat. Chem. (IF 21.8) Pub Date : 2024-03-18 Pengjie Li, Peng Chen, Fukang Qi, Jinyun Shi, Wenjie Zhu, Jiashuo Li, Peng Zhang, Han Xie, Lina Li, Mengcheng Lei, Xueqing Ren, Wenhui Wang, Liang Zhang, Xufu Xiang, Yiwei Zhang, Zhaolong Gao, Xiaojun Feng, Wei Du, Xin Liu, Limin Xia, Bi-Feng Liu, Yiwei Li
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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates Nat. Chem. (IF 21.8) Pub Date : 2024-03-12 Chiara Morelli, Lenka Faltova, Umberto Capasso Palmiero, Katarzyna Makasewicz, Marcell Papp, Raphaël P. B. Jacquat, Dorothea Pinotsi, Paolo Arosio
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Porphyrin-fused graphene nanoribbons Nat. Chem. (IF 21.8) Pub Date : 2024-03-08 Qiang Chen, Alessandro Lodi, Heng Zhang, Alex Gee, Hai I. Wang, Fanmiao Kong, Michael Clarke, Matthew Edmondson, Jack Hart, James N. O’Shea, Wojciech Stawski, Jonathan Baugh, Akimitsu Narita, Alex Saywell, Mischa Bonn, Klaus Müllen, Lapo Bogani, Harry L. Anderson
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Reconfiguring hydrogel assemblies using a photocontrolled metallopolymer adhesive for multiple customized functions Nat. Chem. (IF 21.8) Pub Date : 2024-03-08 Jiahui Liu, Yun-Shuai Huang, Yazhi Liu, Dachuan Zhang, Kaloian Koynov, Hans-Jürgen Butt, Si Wu
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Exploring the frontiers of condensed-phase chemistry with a general reactive machine learning potential Nat. Chem. (IF 21.8) Pub Date : 2024-03-07 Shuhao Zhang, Małgorzata Z. Makoś, Ryan B. Jadrich, Elfi Kraka, Kipton Barros, Benjamin T. Nebgen, Sergei Tretiak, Olexandr Isayev, Nicholas Lubbers, Richard A. Messerly, Justin S. Smith
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The importance of community as a pre-tenure faculty member Nat. Chem. (IF 21.8) Pub Date : 2024-03-06 Shira Joudan
Becoming an assistant professor brings with it several challenges, one of which is developing new relationships that can be professionally and personally beneficial. Shira Joudan reflects on getting to know people at a new institution, having different types of relationships, and how they help with happiness and success.
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A blueprint for catalysis Nat. Chem. (IF 21.8) Pub Date : 2024-03-06 Ciro Romano, Jack I. Mansell, David J. Procter
Ciro Romano, Jack I. Mansell, and David J. Procter have explored the versatility and selectivity of samarium diiodide, and its use as a radical relay catalyst.
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The anti-aromatic dianion and aromatic tetraanion of [18]annulene Nat. Chem. (IF 21.8) Pub Date : 2024-03-06 Wojciech Stawski, Yikun Zhu, Igor Rončević, Zheng Wei, Marina A. Petrukhina, Harry L. Anderson