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Rigid Fe(III) Chelate with Phosphonate Pendants: A Stable and Effective Extracellular MRI Contrast Agent J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Ling He, Haiyu Wang, Zuhua Zeng, Lei Zhong, Qingxuan Tang, Junlai Yu, Jia Tian, Tianwei Liu, Jiang Zhu
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Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Marie-Gabrielle Braun, Avi Ashkenazi, Ramsay E. Beveridge, Georgette Castanedo, Heidi Ackerly Wallweber, Maureen H. Beresini, Kevin R. Clark, Tom De Bruyn, Liqiang Fu, Paul Gibbons, Fan Jiang, Susan Kaufman, David Kan, James R. Kiefer, Jean-Philippe Leclerc, Alexandre Lemire, Cuong Ly, Ehud Segal, Jessica Sims, Weiru Wang, Wentao Wei, Liang Zhao, Jacob B. Schwarz, Joachim Rudolph
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Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Hina Andleeb, Roger L. Papke, Clare Stokes, Katrin Richter, Sara M. Herz, Ka Chiang, Siva R. Raju Kanumuri, Abhisheak Sharma, M. Imad Damaj, Veronika Grau, Nicole A. Horenstein, Ganesh A. Thakur
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Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Luca Carlino, Peter C. Astles, Bryony Ackroyd, Afshan Ahmed, Christina Chan, Gavin W. Collie, Ian L. Dale, Daniel H. O’Donovan, Caroline Fawcett, Paolo di Fruscia, Andrea Gohlke, Xiaoxiao Guo, Jessie Hao-Ru Hsu, Bethany Kaplan, Alexander G. Milbradt, Sarah Northall, Dušan Petrović, Emma L. Rivers, Elizabeth Underwood, Alice Webb
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Two-Photon Photodegradation of E3 Ubiquitin Ligase Cereblon by a Ru(II) Complex: Inducing Ferroptosis in Cisplatin-Resistant Tumor Cells J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Xinlin Lin, Mengsi Zheng, Kai Xiong, Fa Wang, Yu Chen, Liangnian Ji, Hui Chao
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Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Shuanghu Wang, Zhihua Kong, Yaru Shi, Chuxiao Shao, Wei Wang, Zhenhong Su, Jin Liu, Yingxing Zhou, Xiaoting Fei, Binbin Cheng, Jianjun Chen, Yiyu Lu, Jian Xiao
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Nonclassical Zwitterions as a Design Principle to Reduce Lipophilicity without Impacting Permeability J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Henrik Möbitz, Birger Dittrich, Stephane Rodde, Ross Strang
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Enhancing Molecular Property Prediction through Task-Oriented Transfer Learning: Integrating Universal Structural Insights and Domain-Specific Knowledge J. Med. Chem. (IF 7.3) Pub Date : 2024-05-15 Yanjing Duan, Xixi Yang, Xiangxiang Zeng, Wenxuan Wang, Youchao Deng, Dongsheng Cao
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Publisher Correction: Roflumilast Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-15 Leonardo M. Fabbri, Bianca Beghé, Uma Yasothan, Peter Kirkpatrick
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Combating antimicrobial resistance in malaria, HIV and tuberculosis Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-15 Maëlle Duffey, Robert W. Shafer, Juliano Timm, Jeremy N. Burrows, Nader Fotouhi, Mark Cockett, Didier Leroy
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Tackling the challenges of new approach methods for predicting drug effects from model systems Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-15 Paul D. Pang, Syed Mukhtar Ahmed, Masataka Nishiga, Norman L. Stockbridge, Joseph C. Wu
The passage of the FDA Modernization Act 2.0 in 2022 has provided additional impetus to develop new approach methods for predicting the effects of drug candidates in humans from models such as microphysiological systems based on human-derived induced pluripotent stem cells. Here, we highlight progress in the field and strategies to address various challenges, including the application of artificial
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Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Yael Wolff Sagy, Gil Lavie, Noga Ramot, Erez Battat, Ronen Arbel, Orna Reges, Dror Dicker
Comparative evidence for the effects of bariatric metabolic surgery (BMS) and glucagon-like peptide-1 receptor agonists (GLP1-RA) on cardiovascular outcomes is limited. Here, in an observational, retrospective cohort study, we compared the incidence of Congestive Heart Failure (CHF) in adults living with obesity and diabetes without history of CHF (primary CHF) treated with BMS versus GLP-1RA. The
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The evolution of personalized nutrition Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Josef Neu
Data from a large randomized trial show that a personalized diet can improve cardiometabolic health, providing support for a ‘food as medicine’ concept that, although centuries old, still lacks robust evidence.
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Heat exposure induced risks of preterm birth mediated by maternal hypertension Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Liyun Wang, Jiangli Di, Qiong Wang, Huanhuan Zhang, Wei Zhao, Xiaoming Shi, Qian Di, John S. Ji, Wannian Liang, Cunrui Huang
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Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Xiaohua Wu, Jihong Liu, Jing Wang, Li Wang, Zhongqiu Lin, Xiaobin Wang, Jianqing Zhu, Beihua Kong, Junwei Fei, Ying Tang, Bairong Xia, Zhiqing Liang, Ke Wang, Yi Huang, Hong Zheng, An Lin, Kui Jiang, Wei Wang, Xin Wang, Ge Lou, Hongming Pan, Shuzhong Yao, Guiling Li, Min Hao, Yunlang Cai, Xuejun Chen, Zhijun Yang, Youguo Chen, Hongwu Wen, Pengpeng Qu, Cong Xu, Chih-Yi Hsieh
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Structure–Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist J. Med. Chem. (IF 7.3) Pub Date : 2024-05-13 Deepender Kaushik, Arshpreet Kaur, Madhuri T. Patil, Binita Sihag, Sakshi Piplani, Isaac Sakala, Yoshikazu Honda-Okubo, Saravanan Ramakrishnan, Nikolai Petrovsky, Deepak B. Salunke
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CXCR4 chemokine antagonist scores a first FDA approval for WHIM syndrome Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-13
Discover the world’s best science and medicine | Nature.com
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Bispecific antibody takes a BiTE out of B cells in rheumatoid arthritis Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-13
Discover the world’s best science and medicine | Nature.com
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Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Kohei Shitara, Yung-Jue Bang, Satoru Iwasa, Naotoshi Sugimoto, Min-Hee Ryu, Daisuke Sakai, Hyun Cheol Chung, Hisato Kawakami, Hiroshi Yabusaki, Yasuhiro Sakamoto, Tomohiro Nishina, Koichiro Inaki, Yusuke Kuwahara, Naoya Wada, Fumitaka Suto, Takeo Arita, Masahiro Sugihara, Zenta Tsuchihashi, Kaku Saito, Akihito Kojima, Kensei Yamaguchi
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Prevalence of comorbidities in individuals with neurodevelopmental disorders from the aggregated phenomics data of 51,227 pediatric individuals Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Alexander J. M. Dingemans, Sandra Jansen, Jeroen van Reeuwijk, Nicole de Leeuw, Rolph Pfundt, Janneke Schuurs-Hoeijmakers, Bregje W. van Bon, Carlo Marcelis, Charlotte W. Ockeloen, Marjolein Willemsen, Pleuntje J. van der Sluijs, Gijs W. E. Santen, R. Frank Kooy, Anneke T. Vulto-van Silfhout, Tjitske Kleefstra, David A. Koolen, Lisenka E. L. M. Vissers, Bert B. A. de Vries
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Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Md Shafiqur Rahman, Emma Harrison, Heather Biggs, Chloe Seikus, Paul Elliott, Gerome Breen, Nathalie Kingston, John R. Bradley, Steven M. Hill, Brian D. M. Tom, Patrick F. Chinnery
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Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Jeffrey Sevigny, Olga Uspenskaya, Laura Dean Heckman, Li Chin Wong, Daniel A. Hatch, Ambika Tewari, Rik Vandenberghe, David J. Irwin, Dario Saracino, Isabelle Le Ber, Rebekah Ahmed, Jonathan D. Rohrer, Adam L. Boxer, Sebastian Boland, Patricia Sheehan, Alissa Brandes, Suzanne R. Burstein, Benjamin M. Shykind, Sitharthan Kamalakaran, Carter W. Daniels, E. David Litwack, Erin Mahoney, Jenny Velaga, Ilan
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The efficacy of dapagliflozin in a hierarchical kidney outcome in heart failure Nat. Med. (IF 82.9) Pub Date : 2024-05-13
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Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Donna H. Ryan, Ildiko Lingvay, John Deanfield, Steven E. Kahn, Eric Barros, Bartolome Burguera, Helen M. Colhoun, Cintia Cercato, Dror Dicker, Deborah B. Horn, G. Kees Hovingh, Ole Kleist Jeppesen, Alexander Kokkinos, A. Michael Lincoff, Sebastian M. Meyhöfer, Tugce Kalayci Oral, Jorge Plutzky, André P. van Beek, John P. H. Wilding, Robert F. Kushner
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Discovery of Oral AMP-Activated Protein Kinase Activators for Treating Hyperlipidemia J. Med. Chem. (IF 7.3) Pub Date : 2024-05-13 Mingchao Wang, Zunsheng Han, Baoyan Fan, Kai Qu, Wenxuan Zhang, Wei Li, Jingya Li, Li Li, Jin Li, Hui Li, Song Wu, Dongmei Wang, Haibo Zhu
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Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy J. Med. Chem. (IF 7.3) Pub Date : 2024-05-13 Zichao Yang, Ziqing Liu, Shanhe Wan, Jianwei Xu, Yaqi Huang, Haiqi He, Ting Liu, Ling Li, Yichang Ren, Jiajie Zhang, Jianjun Chen
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Tumor-Targeted Oxaliplatin(IV) Prodrug Delivery Based on ROS-Regulated Cancer-Selective Glycan Labeling J. Med. Chem. (IF 7.3) Pub Date : 2024-05-13 Jiajia Wang, Wei Cao, Wei Zhang, Biao Dou, Xin Ding, Menghe Wang, Jing Ma, Xia Li
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Modular Biomimetic Strategy Enables Discovery and SAR Exploration of Oxime Macrocycles as Influenza A Virus (H1N1) Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-05-12 Dandan Xu, Ying Gong, Lianju Zhang, Fu Xiao, Xinran Wang, Ji Qin, Lin Tan, Teng Yang, Zeng Lin, Zhongliang Xu, Xiujuan Liu, Fuling Xiao, Feili Zhang, Feng Tang, Jianping Zuo, Xiaomin Luo, Wei Huang, Li Yang, Weibo Yang
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Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains J. Med. Chem. (IF 7.3) Pub Date : 2024-05-11 Margaret Phillips, Kiera L. Malone, Brian W. Boyle, Cameron Montgomery, Isabelle A. Kressy, Faith M. Joseph, Kathleen M. Bright, Samuel P. Boyson, Sunsik Chang, Jay C. Nix, Nicolas L. Young, Victoria Jeffers, Seth Frietze, Karen C. Glass
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Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Antonio Romero, Luke Ashcraft, Aroop Chandra, Vincent DiMassa, Peadar Cremin, Scott E. Collibee, Chihyuan Chuang, James Hartman, Darren T. Hwee, David St. Jean, Justin Malinowski, Mikkel DeBenedetto, David Moebius, Joshua Payette, Richard Vargas, John Yeoman, Alykhan Motani, Jeffrey Reagan, Fady I. Malik, Bradley P. Morgan
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A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Di Zhu, Yu Lu, Zhanchao Yan, Qian Deng, Bo Hu, Yinsong Wang, Wenjing Wang, Yanming Wang, Yuji Wang
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Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum(IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug Resistance J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Xiaochao Huang, Guimei Li, Huifang Li, Wentian Zhong, Guiyang Jiang, Jinyuan Cai, Qingping Xiong, Chuang Wu, Kangning Su, Rizhen Huang, Shiliu Xu, Zhikun Liu, Meng Wang, Hengshan Wang
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Discovery of LLC355 as an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1 J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Lianchao Liu, Lijie Zhao, Lujun Yang, Minxue Chai, Zhengyong Liu, Nan Ma, Yongxing Wang, Qinxue Wu, Jing Guo, Fengtao Zhou, Weixue Huang, Xiaomei Ren, Jian Wang, Ming Ding, Zhen Wang, Ke Ding
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Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Emmanuel A. Meyer, Andrew L. Croxford, Carmela Gnerre, Paulina Kulig, Mark J. Murphy, Elise M. Jacob, Gabriel Schäfer, Sylvia Richard-Bildstein, Hamed Aissaoui, Patrick Bouis, Eric A. Ertel, Ruben de Kanter, Marcel P. Keller, Urs Lüthi, Eva Caroff
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Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Anna Vulpetti, Jean-Michel Rondeau, Marie-Hélène Bellance, Jutta Blank, Ralf Boesch, Andreas Boettcher, Frédéric Bornancin, Sylvia Buhr, Lauren E. Connor, Christoph E. Dumelin, Oliver Esser, Michael Hediger, Samuel Hintermann, Ulrich Hommel, Elke Koch, Guillaume Lapointe, Lukas Leder, Sylvie Lehmann, Philipp Lehr, Peter Meier, Lionel Muller, Daniela Ostermeier, Paul Ramage, Sihame Schiebel-Haddad,
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Rational Design and Pharmacomodulation of 18F-Labeled Biotin/FAPI-Conjugated Heterodimers J. Med. Chem. (IF 7.3) Pub Date : 2024-05-10 Xuedong Chen, Dongsheng Xia, Xueyuan Zeng, Lingxin Meng, Yanjie Wang, Huifeng Li, Jingru Zhang, Zuoquan Zhao, Rongqiang Zhuang, Jianyang Fang, Xianzhong Zhang, Zhide Guo
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Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases J. Med. Chem. (IF 7.3) Pub Date : 2024-05-09 Lingfeng Chen, Ruixiang Luo, Lin Ma, Ying Xu, Jiaqi Cao, Zheng Jiang, Shiyan Chen, Xiaohao Huang, Mingwan Zhang, Lei Zheng, Yawen Zhang, Lina Yin, Jie Yu, Xiaochun Zheng, Lulu Zheng, Ping Huang, Guang Liang
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Design of FK866-Based Degraders for Blocking the Nonenzymatic Functions of Nicotinamide Phosphoribosyltransferase J. Med. Chem. (IF 7.3) Pub Date : 2024-05-09 Tiangong Lu, Fangfang Chen, Jian Yao, Zixuan Bu, Armita Kyani, Benji Liang, Shaoting Chen, Yuxiang Zheng, Hong Liang, Nouri Neamati, Yanghan Liu
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Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents J. Med. Chem. (IF 7.3) Pub Date : 2024-05-09 Papireddy Kancharla, Diana Ortiz, Corinne M. Fargo, Xiaowei Zhang, Yuexin Li, Marco Sanchez, Amrendra Kumar, Monish Yeluguri, Rozalia A. Dodean, Diana Caridha, Michael S. Madejczyk, Monica Martin, Xiannu Jin, Cameron Blount, Ravi Chetree, Kristina Pannone, Hieu T. Dinh, Jesse DeLuca, Martin Evans, Robert Nadeau, Chau Vuong, Susan Leed, William E. Dennis, Norma Roncal, Brandon S. Pybus, Patricia J.
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Identification of 1,3,4-Thiadiazolyl-Containing Thiazolidine-2,4-dione Derivatives as Novel PTP1B Inhibitors with Antidiabetic Activity J. Med. Chem. (IF 7.3) Pub Date : 2024-05-09 Mengyue Li, Huiyun Li, Xiaofeng Min, Jinping Sun, Bingwen Liang, Lei Xu, Jia Li, Shao-Hua Wang, Xuetao Xu
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Selenization of Small Molecule Drugs: A New Player on the Board J. Med. Chem. (IF 7.3) Pub Date : 2024-05-08 Cristina Morán-Serradilla, Daniel Plano, Carmen Sanmartín, Arun K. Sharma
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Exploring the Structural Attributes of Yoda1 for the Development of New-Generation Piezo1 Agonist Yaddle1 as a Vaccine Adjuvant Targeting Optimal T Cell Activation J. Med. Chem. (IF 7.3) Pub Date : 2024-05-08 Sunny Goon, Chinky Shiu Chen Liu, Uddipta Ghosh Dastidar, Barnali Paul, Suravi Mukherjee, Himadri Sekhar Sarkar, Milie Desai, Rituparna Jana, Sourav Pal, Namala Venkata Sreedevi, Dipyaman Ganguly, Arindam Talukdar
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Discovery of Glutamate Carboxypeptidase III Ligands to Compete the Uptake of [177Lu]Lu-PSMA-617 in Healthy Organs J. Med. Chem. (IF 7.3) Pub Date : 2024-05-08 Marco Müller, Laura Lucaroni, Nicholas Favalli, Gabriele Bassi, Dario Neri, Samuele Cazzamalli, Sebastian Oehler
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Synthesis of Heterocyclic Ring-Fused Bisnoralcohol Derivatives as Novel Small-Molecule Antiosteoporosis Agents J. Med. Chem. (IF 7.3) Pub Date : 2024-05-08 De-Jie Zhang, Rong Chen, Yu-Xin Zhang, Chen-Chen Li, Ruo-Nan Ning, Min Jiang, Wen-Wei Qiu
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Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment J. Med. Chem. (IF 7.3) Pub Date : 2024-05-08 Shuai Yu, Yan-Qin He, Yating Liu, Shilei Ji, Yajing Wang, Bin Sun
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Rational Design and Comparison of Novel 99mTc-Labeled FAPI Dimers for Visualization of Multiple Tumor Types J. Med. Chem. (IF 7.3) Pub Date : 2024-05-08 Lingxin Meng, Jianyang Fang, Jingru Zhang, Huifeng Li, Dongsheng Xia, Rongqiang Zhuang, Haojun Chen, Jinxiong Huang, Yesen Li, Xianzhong Zhang, Zhide Guo
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Frameworks for transformational breakthroughs in RNA-based medicines Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-13 John R. Androsavich
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Refining neoadjuvant immunotherapy for resectable lung cancer Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Misty D. Shields, Christine M. Lovly
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Gut bacteria switch A and B blood types to ‘universal’ Nat. Med. (IF 82.9) Pub Date : 2024-05-13
Enzymes produced by Akkermansia muciniphila generated group O blood by degrading A and B antigens, which could help solve blood donor shortages in the future.
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Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Yan-Ran (Joyce) Wang, Kai Yang, Yi Wen, Pengcheng Wang, Yuepeng Hu, Yongfan Lai, Yufeng Wang, Kankan Zhao, Siyi Tang, Angela Zhang, Huayi Zhan, Minjie Lu, Xiuyu Chen, Shujuan Yang, Zhixiang Dong, Yining Wang, Hui Liu, Lei Zhao, Lu Huang, Yunling Li, Lianming Wu, Zixian Chen, Yi Luo, Dongbo Liu, Pengbo Zhao, Keldon Lin, Joseph C. Wu, Shihua Zhao
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Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Yue Zeng, Chun-Hong Hu, Yi-Zheng Li, Jian-Song Zhou, Shu-Xing Wang, Meng-Dong Liu, Zhen-Hua Qiu, Chao Deng, Fang Ma, Chun-Fang Xia, Fei Liang, Yu-Rong Peng, Ao-Xi Liang, Sheng-Hao Shi, Shi-Jiao Yao, Jun-Qi Liu, Wen-Jie Xiao, Xiao-Qiao Lin, Xin-Yu Tian, Ying-Zhe Zhang, Zhuo-Ying Tian, Ji-An Zou, Yun-Shu Li, Chao-Yue Xiao, Tian Xu, Xiao-Jie Zhang, Xiao-Ping Wang, Xian-Ling Liu, Fang Wu
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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Alexander J. Mentzer, Alexander T. Dilthey, Martin Pollard, Deepti Gurdasani, Emre Karakoc, Tommy Carstensen, Allan Muhwezi, Clare Cutland, Amidou Diarra, Ricardo da Silva Antunes, Sinu Paul, Gaby Smits, Susan Wareing, HwaRan Kim, Cristina Pomilla, Amanda Y. Chong, Debora Y. C. Brandt, Rasmus Nielsen, Samuel Neaves, Nicolas Timpson, Austin Crinklaw, Cecilia S. Lindestam Arlehamn, Anna Rautanen, Dennison
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Artificial intelligence in surgery Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Chris Varghese, Ewen M. Harrison, Greg O’Grady, Eric J. Topol
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New route to target RAS Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-10
Discover the world’s best science and medicine | Nature.com
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Studying paired patient tissue and blood enables insights into immunotherapy toxicity Nat. Med. (IF 82.9) Pub Date : 2024-05-09
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Gene therapy trials deliver double win Nat. Med. (IF 82.9) Pub Date : 2024-05-09
Final results of two studies — whose preliminary data led to regulatory approval of the gene therapy exagamglogene autotemcel — describe highly effective treatment of sickle-cell disease and transfusion-dependent β-thalassemia.
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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis Nat. Med. (IF 82.9) Pub Date : 2024-05-09 Molly Fisher Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen, Nandini Samanta, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal P. Smith, Alice Tirard, Swetha Ramesh, Benjamin Y. Arnold, Linda T. Nieman, Jonathan H. Chen, Thomas Eisenhaure, Karin Pelka, Yuhui Song, Katherine H. Xu, Vjola Jorgji, Christopher J. Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan J. Sullivan
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WRN inhibitors squeeze cancer cell vulnerability Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-08
Discover the world’s best science and medicine | Nature.com
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Development of Chinese innovative drugs in the USA Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-08
Discover the world’s best science and medicine | Nature.com
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First, do no harm: a global perspective on diversity and inclusion in clinical trials Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-05-08 Katharine Wright, Willyanne DeCormier Plosky, Hayat R. Ahmed, Sarah A. White, Barbara E. Bierer
New requirements for clinical trial sponsors to submit diversity action plans to the US Food and Drug Administration (FDA) are an important step to embed planning for diverse representation in clinical trial research. These must not, however, be implemented in ways that are detrimental to other countries’ health and research interests.