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The QuEST LAC network uses data to promote evidence-based policies for health in Latin America Nat. Med. (IF 82.9) Pub Date : 2024-06-11 Patricia J. García, Hannah Leslie, Jesús Medina-Ranilla, Laura Espinoza-Pajuelo, Marina Guglielmino, Javier Roberti, Agustina Mazzoni, Ezequiel García-Elorrio
Today’s healthcare landscape is characterized by evolving needs and heightened public expectations, and requires exceptional healthcare systems. These health systems must be capable of delivering consistently high quality, tailored care in a variety of contexts. Quality health systems are needed for the overall wellbeing and fulfilment of communities, to build trust and to achieve better health outcomes1
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Gut microbial age modulates cardiovascular disease risk in metabolically unhealthy older people Nat. Med. (IF 82.9) Pub Date : 2024-06-11
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Predicting breast cancer risk in women of African ancestry Nat. Med. (IF 82.9) Pub Date : 2024-06-10
The largest genome-wide association study of its kind has identified new markers for risk prediction in women of African ancestry — helping to bridge disparities in clinical genomics.
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To respond to the threat of avian influenza, look back at lessons learned from COVID-19 Nat. Med. (IF 82.9) Pub Date : 2024-06-10
Tackling an avian influenza virus strain with pandemic potential should be straightforward — if lessons from the COVID-19 pandemic are heeded.
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Mapping fibrosis pathways with MRI and genetic association analyses Nat. Med. (IF 82.9) Pub Date : 2024-06-10
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Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial Nat. Med. (IF 82.9) Pub Date : 2024-06-10 Arun J. Sanyal, Lee M. Kaplan, Juan P. Frias, Bram Brouwers, Qiwei Wu, Melissa K. Thomas, Charles Harris, Nanette C. Schloot, Yu Du, Kieren J. Mather, Axel Haupt, Mark L. Hartman
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Novel medical devices to address the opioid crisis Nat. Med. (IF 82.9) Pub Date : 2024-06-07 Leonardo M. Angelone, Kathryn Capanna, Tracy Gray, Stacie Gutowski, Joseph Kotarek, Elena Koustova, Jonathan Pollock, Eva Rorer, Michelle E. Tarver, Jisun Yi
In 2022, over 100,000 people in the United States died from a drug overdose1. The scope and complexity of the opioid crisis is staggering, and there is an urgent need to offer new solutions, including medical devices, to affected people, families and communities. Funding opportunities, patient-driven design, regulatory clarity and available reimbursement paths could spur high-quality, safe and effective
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Sustained aviraemia despite anti-retroviral therapy non-adherence in male children following in utero hiv transmission Nat. Med. (IF 82.9) Pub Date : 2024-06-06 Nomonde Bengu, Gabriela Cromhout, Emily Adland, Katya Govender, Nicholas Herbert, Nicholas Lim, Rowena Fillis, Kenneth Sprenger, Vinicius Vieira, Samantha Kannie, Jeroen van Lobenstein, Kogielambal Chinniah, Constant Kapongo, Roopesh Bhoola, Malini Krishna, Noxolo Mchunu, Giuseppe Rubens Pascucci, Nicola Cotugno, Paolo Palma, Alfredo Tagarro, Pablo Rojo, Julia Roider, Maria C. Garcia-Guerrero, Christina
Following sporadic reports of post-treatment control of HIV in children who initiated combination antiretroviral therapy (cART) early, we here prospectively studied 284 very early cART-treated children from KwaZulu-Natal, South Africa after vertical HIV transmission to assess control of viraemia. 84% of the children achieved aviraemia on cART but aviraemia persisting to >36m was observed in only 32%
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Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk Nat. Med. (IF 82.9) Pub Date : 2024-06-06 Tiange Wang, Zhun Shi, Huahui Ren, Min Xu, Jieli Lu, Fangming Yang, Chaojie Ye, Kui Wu, Mingling Chen, Xun Xu, Dong Liu, Lijie Kong, Ruizhi Zheng, Jie Zheng, Mian Li, Yu Xu, Zhiyun Zhao, Yuhong Chen, Huanming Yang, Jian Wang, Guang Ning, Junhua Li, Huanzi Zhong, Yufang Bi, Weiqing Wang
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A cost-effectiveness analysis of early detection and bundled treatment of postpartum hemorrhage alongside the E-MOTIVE trial Nat. Med. (IF 82.9) Pub Date : 2024-06-06 Eleanor V. Williams, Ilias Goranitis, Raymond Oppong, Samuel J. Perry, Adam J. Devall, James T. Martin, Kristie-Marie Mammoliti, Leanne E. Beeson, Kulandaipalayam N. Sindhu, Hadiza Galadanci, Fadhlun Alwy Al‑beity, Zahida Qureshi, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Sibongile Mandondo, Lee Middleton, Karla Hemming, Olufemi T. Oladapo, Ioannis D. Gallos, Arri Coomarasamy, Tracy E. Roberts
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Oncolytic adenoviral therapy plus pembrolizumab in BCG-unresponsive non-muscle-invasive bladder cancer: the phase 2 CORE-001 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-06 Roger Li, Paras H. Shah, Tyler F. Stewart, Jong Kil Nam, Trinity J. Bivalacqua, Donald L. Lamm, Edward M. Uchio, Daniel M. Geynisman, Joseph M. Jacob, Joshua J. Meeks, Rian Dickstein, Shane M. Pearce, Seok Ho Kang, Seung Il Jung, Ashish M. Kamat, James M. Burke, Kirk A. Keegan, Gary D. Steinberg
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Precision-guided treatment in high-risk pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-06-06 Loretta M. S. Lau, Dong-Anh Khuong-Quang, Chelsea Mayoh, Marie Wong, Paulette Barahona, Pamela Ajuyah, Akanksha Senapati, Sumanth Nagabushan, Alexandra Sherstyuk, Ann-Kristin Altekoester, Noemi A. Fuentes-Bolanos, Veronica Yeung, Ashleigh Sullivan, Natacha Omer, Yonatan Diamond, Sophie Jessop, Lauren Battaglia, Nataliya Zhukova, Louise Cui, Angela Lin, Andrew J. Gifford, Emmy D. G. Fleuren, Luciano
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Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-06 Yi-Bin Chen, Mohamad Mohty, Robert Zeiser, Takanori Teshima, Omer Jamy, Johan Maertens, Duncan Purtill, Jingjing Chen, Hong Cao, Guillermo Rossiter, Johan Jansson, Yngvar Fløisand
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Gene therapy for hereditary deafness Nat. Med. (IF 82.9) Pub Date : 2024-06-05 Carson Smith, Mohammad Faraz Zafeer, Mustafa Tekin
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Thromboembolic events and vascular dementia in patients with atrial fibrillation and low apparent stroke risk Nat. Med. (IF 82.9) Pub Date : 2024-06-05 Alastair R. Mobley, Anuradhaa Subramanian, Asgher Champsi, Xiaoxia Wang, Puja Myles, Paul McGreavy, Karina V. Bunting, David Shukla, Krishnarajah Nirantharakumar, Dipak Kotecha
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Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results Nat. Med. (IF 82.9) Pub Date : 2024-06-05 Hui Wang, Yuxin Chen, Jun Lv, Xiaoting Cheng, Qi Cao, Daqi Wang, Longlong Zhang, Biyun Zhu, Min Shen, Chunxin Xu, Mengzhao Xun, Zijing Wang, Honghai Tang, Shaowei Hu, Chong Cui, Luoying Jiang, Yanbo Yin, Luo Guo, Yi Zhou, Lei Han, Ziwen Gao, Jiajia Zhang, Sha Yu, Kaiyu Gao, Jinghan Wang, Bing Chen, Wuqing Wang, Zheng-Yi Chen, Huawei Li, Yilai Shu
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CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-05 E. William St. Clair, Alan N. Baer, Wan-Fai Ng, Ghaith Noaiseh, Chiara Baldini, Teresa K. Tarrant, Athena Papas, Valerie Devauchelle-Pensec, Liangwei Wang, Wenjing Xu, Tuyet-Hang Pham, Keith Sikora, William A. Rees, Ilias Alevizos
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The pandemic treaty: a grand global social bargain Nat. Med. (IF 82.9) Pub Date : 2024-06-05
The treaty is a grand social bargain of open sharing of crucial scientific data in real time and equitable allocation of lifesaving medical countermeasures.
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Heritable and spatial immunogenic traits co-predict the efficacy of immunotherapy in kidney cancer Nat. Med. (IF 82.9) Pub Date : 2024-06-04
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Cervical cancer screening using DNA methylation triage in a real-world population Nat. Med. (IF 82.9) Pub Date : 2024-06-04 Lena Schreiberhuber, James E. Barrett, Jiangrong Wang, Elisa Redl, Chiara Herzog, Charlotte D. Vavourakis, Karin Sundström, Joakim Dillner, Martin Widschwendter
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Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial Nat. Med. (IF 82.9) Pub Date : 2024-06-04 Joe Verghese, Rachel Chalmer, Marnina Stimmel, Erica Weiss, Jessica Zwerling, Rubina Malik, David Rasekh, Asif Ansari, Roderick A. Corriveau, Amy R. Ehrlich, Cuiling Wang, Emmeline Ayers
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Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks Nat. Med. (IF 82.9) Pub Date : 2024-06-04 Andrew S. Perry, Eric Farber-Eger, Tomas Gonzales, Toshiko Tanaka, Jeremy M. Robbins, Venkatesh L. Murthy, Lindsey K. Stolze, Shilin Zhao, Shi Huang, Laura A. Colangelo, Shuliang Deng, Lifang Hou, Donald M. Lloyd-Jones, Keenan A. Walker, Luigi Ferrucci, Eleanor L. Watts, Jacob L. Barber, Prashant Rao, Michael Y. Mi, Kelley Pettee Gabriel, Bjoern Hornikel, Stephen Sidney, Nicholas Houstis, Gregory D
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Geographic sources of ozone air pollution and mortality burden in Europe Nat. Med. (IF 82.9) Pub Date : 2024-06-03 Hicham Achebak, Roger Garatachea, María Teresa Pay, Oriol Jorba, Marc Guevara, Carlos Pérez García-Pando, Joan Ballester
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Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial Nat. Med. (IF 82.9) Pub Date : 2024-06-03 Xavier Leleu, Cyrille Hulin, Jerome Lambert, Arthur Bobin, Aurore Perrot, Lionel Karlin, Murielle Roussel, Lydia Montes, Brieuc Cherel, Thomas Chalopin, Borhane Slama, Marie-Lorraine Chretien, Kamel Laribi, Claire Dingremont, Christophe Roul, Clara Mariette, Sophie Rigaudeau, Claire Calmettes, Mamoun Dib, Mourad Tiab, Laure Vincent, Jacques Delaunay, Alberto Santagostino, Margaret Macro, Emmanuelle
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Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results Nat. Med. (IF 82.9) Pub Date : 2024-06-03 Changsong Qi, Chang Liu, Jifang Gong, Dan Liu, Xicheng Wang, Panpan Zhang, Yanru Qin, Sai Ge, Miao Zhang, Zhi Peng, Jun Zhou, Zhihao Lu, Ming Lu, Yanshuo Cao, Jiajia Yuan, Yakun Wang, Zhenghang Wang, Ran Xue, Xiaohui Peng, Yumeng Wang, Daijing Yuan, Jian Li, Xiaotian Zhang, Lin Shen
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Lisocabtagene maraleucel in follicular lymphoma: the phase 2 TRANSCEND FL study Nat. Med. (IF 82.9) Pub Date : 2024-06-03 Franck Morschhauser, Saurabh Dahiya, M. Lia Palomba, Alejandro Martin Garcia-Sancho, Juan Luis Reguera Ortega, John Kuruvilla, Ulrich Jäger, Guillaume Cartron, Koji Izutsu, Martin Dreyling, Brad Kahl, Hervé Ghesquieres, Kirit Ardeshna, Hideki Goto, Anna Maria Barbui, Jeremy S. Abramson, Peter Borchmann, Isabelle Fleury, Stephan Mielke, Alan Skarbnik, Sven de Vos, Manali Kamdar, Reem Karmali, Andreas
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Reducing the risk of highly pathogenic avian influenza A virus H5N1 transmission during the Hajj Nat. Med. (IF 82.9) Pub Date : 2024-06-03
Discover the world’s best science and medicine | Nature.com
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Cell-Free DNA for the detection of kidney allograft rejection Nat. Med. (IF 82.9) Pub Date : 2024-06-02 Olivier Aubert, Cindy Ursule-Dufait, Romain Brousse, Juliette Gueguen, Maud Racapé, Marc Raynaud, Elisabet Van Loon, Angelica Pagliazzi, Edmund Huang, Stanley C. Jordan, Kenneth D. Chavin, Gaurav Gupta, Dhiren Kumar, Tarek Alhamad, Sanjiv Anand, Jorge Sanchez-Garcia, Basmah A. Abdalla, Julien Hogan, Rouba Garro, Darshana M. Dadhania, Pranjal Jain, Didier A. Mandelbrot, Maarten Naesens, Raja Dandamudi
Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker that has the potential to detect allograft injury. The capacity of donor-derived cell-free DNA to detect kidney allograft rejection and its added clinical value beyond standard of care patient monitoring is unclear. We enrolled 2,882 kidney allograft recipients from 14 transplantation centers in Europe and the US in an observational
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Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer: long-term survival analysis of the DESTINY-Breast03 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-02 Javier Cortés, Sara A. Hurvitz, Seock-Ah Im, Hiroji Iwata, Giuseppe Curigliano, Sung-Bae Kim, Joanne W. Y. Chiu, Jose L. Pedrini, Wei Li, Kan Yonemori, Giampaolo Bianchini, Sherene Loi, Giuliano S. Borges, Xian Wang, Thomas Bachelot, Shunsuke Nakatani, Shahid Ashfaque, Zhengkang Liang, Anton Egorov, Erika Hamilton
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Inhibition of lysine acetyltransferase KAT6 in ER+HER2− metastatic breast cancer: a phase 1 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-01 Toru Mukohara, Yeon Hee Park, David Sommerhalder, Kan Yonemori, Erika Hamilton, Sung-Bae Kim, Jee Hyun Kim, Hiroji Iwata, Toshinari Yamashita, Rachel M. Layman, Monica Mita, Timothy Clay, Yee Soo Chae, Catherine Oakman, Fengting Yan, Gun Min Kim, Seock-Ah Im, Geoffrey J. Lindeman, Hope S. Rugo, Marlon Liyanage, Michelle Saul, Christophe Le Corre, Athanasia Skoura, Li Liu, Meng Li, Patricia M. LoRusso
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Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial Nat. Med. (IF 82.9) Pub Date : 2024-06-01 Feng Wang, Lin Shen, Weijian Guo, Tianshu Liu, Jin Li, Shukui Qin, Yuxian Bai, Zhendong Chen, Jufeng Wang, Yueyin Pan, Yongqian Shu, Fuyou Zhao, Ying Cheng, Feng Ye, Kangsheng Gu, Tao Zhang, Hongming Pan, Haijun Zhong, Fuxiang Zhou, Yanru Qin, Lei Yang, Weidong Mao, Qiu Li, Wenxiang Dai, Wei Li, Shubin Wang, Yong Tang, Dong Ma, Xianli Yin, Yanhong Deng, Ying Yuan, Man Li, Wenwei Hu, Donghui Chen, Guoxin
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Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-01 Thomas Powles, Yen-Hwa Chang, Yoshiaki Yamamoto, Jose Munoz, Felipe Reyes-Cosmelli, Avivit Peer, Graham Cohen, Evan Y. Yu, Anja Lorch, Abhishek Bavle, Blanca Homet Moreno, Julia Markensohn, Mackenzie Edmondson, Cai Chen, Razvan Cristescu, Carol Pena, Jared Lunceford, Seyda Gunduz
Circulating tumor DNA (ctDNA) is emerging as a potential biomarker in early-stage urothelial cancer but its utility in metastatic disease remains unknown. In the phase 3 KEYNOTE-361 study, pembrolizumab with and without chemotherapy was compared with chemotherapy alone in patients with metastatic urothelial cancer. The study did not meet prespecified efficacy thresholds for statistical significance
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Surgery versus no surgery in platinum-sensitive relapsed ovarian cancer: final overall survival analysis of the SOC-1 randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-06-01 Rong Jiang, Yanling Feng, Yulian Chen, Xi Cheng, Tingyan Shi, Wen Gao, Huixun Jia, Shiyang Jiang, Yi Guo, Xiao Huang, Dongsheng Tu, Yuqin Zhang, Huijuan Yang, Ping Zhang, Jihong Liu, Jianqing Zhu, Rongyu Zang
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Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders Nat. Med. (IF 82.9) Pub Date : 2024-05-31 Daniel Greene, Chantal Thys, Ian R. Berry, Joanna Jarvis, Els Ortibus, Andrew D. Mumford, Kathleen Freson, Ernest Turro
Most people with intellectual disability (ID) do not receive a molecular diagnosis following genetic testing. To identify new etiologies of ID, we performed a genetic association analysis comparing the burden of rare variants in 41,132 non-coding genes between 5,529 unrelated cases and 46,401 unrelated controls. RNU4-2, which encodes U4 snRNA, a critical component of the spliceosome, was the most strongly
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Building trust and transparency in biomedical sciences through data walks Nat. Med. (IF 82.9) Pub Date : 2024-05-31 Layla Fattah, Jay Johnson, Uraina Clark, Leona Hess, Ann-Gel Palermo, Dania M. Figueroa Acosta, Talia H. Swartz
In biomedical education, inequities are driven mainly by systemic, structural and cultural issues1. These include disparities in access to educational resources, biases in admissions and unequal opportunities in research and clinical experiences2, with a curriculum that may not always cater to all students’ diverse needs and backgrounds. Additional challenges come from the varied nature of laboratory
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Point-of-care testing for sepsis in remote Australia and for First Nations peoples Nat. Med. (IF 82.9) Pub Date : 2024-05-30 Brooke Spaeth, Sean Taylor, Mark Shephard, Richard L. Reed, Rodney Omond, Jonathan Karnon, Billie Bonevski, Chris Rissel, Shahid Ullah, Tina Noutsos, Jacqueline H. Stephens, James A. Smith, Annabelle Wilson, Brett Abbenbroek, Emma de Courcy-Ireland, Simon Finfer
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Multimodal assessment improves neuroprognosis performance in clinically unresponsive critical-care patients with brain injury Nat. Med. (IF 82.9) Pub Date : 2024-05-30 B. Rohaut, C. Calligaris, B. Hermann, P. Perez, F. Faugeras, F. Raimondo, J-.R. King, D. Engemann, C. Marois, L. Le Guennec, L. Di Meglio, A. Sangaré, E. Munoz Musat, M. Valente, A. Ben Salah, A. Demertzi, L. Belloli, D. Manasova, L. Jodaitis, M. O. Habert, V. Lambrecq, N. Pyatigorskaya, D. Galanaud, L. Puybasset, N. Weiss, S. Demeret, F. X. Lejeune, J. D. Sitt, L. Naccache
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Three-year outcomes of post-acute sequelae of COVID-19 Nat. Med. (IF 82.9) Pub Date : 2024-05-30 Miao Cai, Yan Xie, Eric J. Topol, Ziyad Al-Aly
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Tumor infiltrating lymphocyte approval heralds new era for precision cancer immunotherapy Nat. Med. (IF 82.9) Pub Date : 2024-05-30
FDA approval of Iovance’s lifileucel for melanoma shows the promise of tumor-infiltrating lymphocytes for the treatment of solid tumors, with trials ongoing for lung cancer, cervical cancer and more.
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A surprising abundance of pancreatic pre-cancers Nat. Med. (IF 82.9) Pub Date : 2024-05-29
AI-based three-dimensional genomic mapping reveals a large abundance of cancer precursors in normal pancreatic tissue — prompting new insights and research directions.
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Affordable and simplified whole-body MRI Nat. Med. (IF 82.9) Pub Date : 2024-05-29
A whole-body scanner developed using a permanent 0.05-tesla magnet and deep learning has demonstrated its versatility in imaging various anatomical structures, showcasing its potential to address unmet clinical needs.
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Generating clinical evidence for treatment and prevention options for long COVID Nat. Med. (IF 82.9) Pub Date : 2024-05-28 Stephanie Buchholz, Eugenia Di Meco, Ewa Z. Bałkowiec-Iskra, Bruno Sepodes, Marco Cavaleri
Long COVID is a chronic and debilitating disease affecting more than 36 million people in the European Union (EU)1. Most patients are of working age, creating a high burden on healthcare and social systems2. At present, there are no EU-approved medicines for the treatment or prevention of long COVID. The long COVID therapeutic field is at a crossroads, with many study designs being proposed and used
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Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping Nat. Med. (IF 82.9) Pub Date : 2024-05-28 Victor Nauffal, Marcus D. R. Klarqvist, Matthew C. Hill, Danielle F. Pace, Paolo Di Achille, Seung Hoan Choi, Joel T. Rämö, James P. Pirruccello, Pulkit Singh, Shinwan Kany, Cody Hou, Kenney Ng, Anthony A. Philippakis, Puneet Batra, Steven A. Lubitz, Patrick T. Ellinor
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How medical schools can prepare students for new technologies Nat. Med. (IF 82.9) Pub Date : 2024-05-27 Chantal Mathieu
Patient educators and nurses can demonstrate the real-life use of health technologies.
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What the SELECT trial of semaglutide means for clinicians Nat. Med. (IF 82.9) Pub Date : 2024-05-25 Naveed Sattar, Matthew M. Y. Lee, Darren K. McGuire
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IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial Nat. Med. (IF 82.9) Pub Date : 2024-05-25 Glenn M. Chertow, Anna Marie Chang, G. Michael Felker, Mark Heise, Elena Velkoska, Bengt Fellström, David M. Charytan, Regina Clementi, C. Michael Gibson, Shaun G. Goodman, Meg Jardine, Adeera Levin, Yuliya Lokhnygina, Jenny Mears, Roxana Mehran, Peter Stenvinkel, Angela Wang, David C. Wheeler, Carmine Zoccali, Paul M. Ridker, Kenneth W. Mahaffey, Pierluigi Tricoci, Myles Wolf
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Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial Nat. Med. (IF 82.9) Pub Date : 2024-05-25 Helen M. Colhoun, Ildiko Lingvay, Paul M. Brown, John Deanfield, Kirstine Brown-Frandsen, Steven E. Kahn, Jorge Plutzky, Koichi Node, Alexander Parkhomenko, Lars Rydén, John P. H. Wilding, Johannes F. E. Mann, Katherine R. Tuttle, Thomas Idorn, Naveen Rathor, A. Michael Lincoff
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Immune signatures of disease stages and outcomes in myocardial infarction Nat. Med. (IF 82.9) Pub Date : 2024-05-24
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Half a century of immunization success Nat. Med. (IF 82.9) Pub Date : 2024-05-24
A modeling study marking 50 years of vaccination through the Expanded Programme on Immunization of the World Health Organization highlights its lifesaving impact on infant and child health.
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Prediction of recurrence risk in endometrial cancer with multimodal deep learning Nat. Med. (IF 82.9) Pub Date : 2024-05-24 Sarah Volinsky-Fremond, Nanda Horeweg, Sonali Andani, Jurriaan Barkey Wolf, Maxime W. Lafarge, Cor D. de Kroon, Gitte Ørtoft, Estrid Høgdall, Jouke Dijkstra, Jan J. Jobsen, Ludy C. H. W. Lutgens, Melanie E. Powell, Linda R. Mileshkin, Helen Mackay, Alexandra Leary, Dionyssios Katsaros, Hans W. Nijman, Stephanie M. de Boer, Remi A. Nout, Marco de Bruyn, David Church, Vincent T. H. B. M. Smit, Carien
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Microbiome research in Africa must be based on equitable partnerships Nat. Med. (IF 82.9) Pub Date : 2024-05-23 Ovokeraye H. Oduaran, Moréniké Oluwátóyìn Foláyan, Arox W. Kamng’ona, Annettee Nakimuli, Lamech M. Mwapagha, Mathabatha E. Setati, Michael Owusu, Nicola Mulder, Thulani P. Makhalanyane, Soumaya Kouidhi
A framework is presented for equitable and effective microbiome research partnerships between African researchers, international partners, healthcare professionals, policymakers and stakeholders.
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Shooting the moon: the National Cancer Institute’s implementation framework for data sharing policies Nat. Med. (IF 82.9) Pub Date : 2024-05-23 Emily S. Boja, Jaime M. Guidry Auvil
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Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation Nat. Med. (IF 82.9) Pub Date : 2024-05-23 Matt S. Zinter, Christopher C. Dvorak, Madeline Y. Mayday, Gustavo Reyes, Miriam R. Simon, Emma M. Pearce, Hanna Kim, Peter J. Shaw, Courtney M. Rowan, Jeffrey J. Auletta, Paul L. Martin, Kamar Godder, Christine N. Duncan, Nahal R. Lalefar, Erin M. Kreml, Janet R. Hume, Hisham Abdel-Azim, Caitlin Hurley, Geoffrey D. E. Cuvelier, Amy K. Keating, Muna Qayed, James S. Killinger, Julie C. Fitzgerald, Rabi
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Two-year safety outcomes of iPS cell-derived mesenchymal stromal cells in acute steroid-resistant graft-versus-host disease Nat. Med. (IF 82.9) Pub Date : 2024-05-22 Kilian Kelly, Adrian J. C. Bloor, James E. Griffin, Rohini Radia, David T. Yeung, John E. J. Rasko
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Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-22 Xiangyu Gao, Ke Ji, Yongning Jia, Fei Shan, Ye Chen, Nong Xu, Ziyu Jia, Tianshu Liu, Nong Yang, Haijun Zhong, Changzheng Li, Zengqing Guo, Qingxia Fan, Xiaoyan Lin, Yan Zhang, Hui Ren, Hongxia Yang, Zhifang Yao, Wei Liu, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Lin Shen, Ziyu Li, Jiafu Ji
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Turning the tide of early cancer detection Nat. Med. (IF 82.9) Pub Date : 2024-05-21
Next-generation liquid biopsy technologies that target the detection of cell-free DNA with fragments of circulating tumor DNA could be a game-changer in early cancer detection, but their adoption requires further clinical testing and consideration of harm.
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A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma Nat. Med. (IF 82.9) Pub Date : 2024-05-21 Lisa Kinget, Stefan Naulaerts, Jannes Govaerts, Isaure Vanmeerbeek, Jenny Sprooten, Raquel S. Laureano, Nikolina Dubroja, Gautam Shankar, Francesca M. Bosisio, Eduard Roussel, Annelies Verbiest, Francesca Finotello, Markus Ausserhofer, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Louis Boon, Johan Kerkhofs, Jessica Zucman-Rossi, Maarten Albersen, Marcella Baldewijns, Benoit Beuselinck, Abhishek
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Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes Nat. Med. (IF 82.9) Pub Date : 2024-05-21 Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Christoph Gold, Irene V. van Blokland, Roy Oelen, Hilde E. Groot, Jan Walter Benjamins, Sophia Brambs, Rainer Kaiser, Adrian Gottschlich, Gordon Victor Hoffmann, Luke Eivers, Alejandro Martinez-Navarro, Nils Bruns, Susanne Stiller, Sezer Akgöl, Keyang Yue, Vivien Polewka, Raphael Escaig, Markus Joppich, Aleksandar Janjic, Oliver Popp, Sebastian Kobold
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In vivo gene editing for inherited vision loss Nat. Med. (IF 82.9) Pub Date : 2024-05-20
An early-phase trial suggests safety and improvements in vision after treatment with the CRISPR-based therapy EDIT-101, providing proof of concept for in vivo retinal gene editing.
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Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial Nat. Med. (IF 82.9) Pub Date : 2024-05-20 Chet Moritz, Edelle C. Field-Fote, Candace Tefertiller, Ilse van Nes, Randy Trumbower, Sukhvinder Kalsi-Ryan, Mariel Purcell, Thomas W. J. Janssen, Andrei Krassioukov, Leslie R. Morse, Kristin D. Zhao, James Guest, Ralph J. Marino, Lynda M. Murray, Jill M. Wecht, Markus Rieger, Jared Pradarelli, Amanda Turner, Jessica D’Amico, Jordan W. Squair, Gregoire Courtine