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Copper-catalyzed sulfonamidation of enol silyl ether via SO2 insertion towards the synthesis of β-keto sulfonamides Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-15 Qinqiong Zeng, Yujia Gong, Xuemei Zhang, Zhong Lian
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Acid–solvent cluster-catalyzed general and regioselective Friedel–Crafts arylation of alcohols Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-13 Wanting Fu, Junkai Fu, Xi Wang, Yuanli Ding, Yang Li, Jing Tian, Jinbo Zhao, Meiyan Wang, Zikun Wang
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Assembly and Disassembly of Supramolecular Hypervalent Iodine Macrocycles via Anion Coordination J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Krishna Pandey, Samsul Arafin, Eli Jones, Yachu Du, Gajanan C. Kulkarni, Ain Uddin, Toby J. Woods, Kyle N. Plunkett
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Pyridinium Ylide-Mediated Diastereoselective Synthesis of Spirocyclopropanyl-pyrazolones via Cascade Michael/Substitution Reaction J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Akanksha Kumari, Dhirajkumar Jitendrabhai Patanvadiya, Anshul Jain, Ranjan Patra, Manikandan Paranjothy, Nirmal K. Rana
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Quasi-Podands with 1,2,3-Triazole Rings from Bile Acid Derivatives: Synthesis, and Spectroscopic and Theoretical Studies J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Anna Kawka, Hanna Koenig, Damian Nowak, Tomasz Pospieszny
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Electrochemical Reductive Cross-Coupling of Alkyl or Alkenyl Halides with gem-Difluoroalkenes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Hong Zhang, Zenghui Ye, Jiyuan Tang, Yanqi Wu, Xi Zhang, Weiyuan Ma, Zhajun Zhan, Fengzhi Zhang
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Palladium-Catalyzed Three-Component Cascade Carbonylation Reaction to Construct Benzofuran Derivatives J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Ming Li, Shanmei Xu, Dong-Ping Chen, Fan Gao, Shun-Xi Li, Shuang-Xi Zhu, Yi-Feng Qiu, Zheng-Jun Quan, Xi-Cun Wang, Yong-Min Liang
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Synthesis of Benzo[e][1,4,3]oxathiazin-3-one 1-Oxides from NH-S-(2-Hydroxyaryl)sulfoximines J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Kiruthika Periasamy, Pit van Bonn, Runa Tschekorsky Orloff, Nils Völcker, Qiulan Lu, Kari Rissanen, Carsten Bolm
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Synthesis of N2-trans-isosafrole-dG-adduct Bearing DNAs and the Bypass Studies with Human TLS Polymerases κ and η J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Siddharam Shivappa Bagale, Priyanka U. Deshmukh, Shailesh B. Lad, Akhil Sudarsan, Sruthi Sudhakar, Soumyadeep Mandal, Kiran Kondabagil, P. I. Pradeepkumar
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Synthesis of Perdeuterated Alkyl Amines/Amides with Pt/C as Catalyst under Mild Conditions J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Hong-Hai Zhang, Meng-Zhe Chen, Xinbin Yu, Peter V. Bonnesen, Zili Wu, Hsin-Lung Chen, Hugh O’Neill
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Synthesis of Branch-Type 3-Allylindoles from N-Alkyl-N-cinnamyl-2-ethynylaniline Derivatives Using π–Allylpalladium Chloride Complex as a Catalyst J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Kohei Watanabe, Keita Nakano, Hayato Sato, Toshiki Yamaoka, Yasushi Yoshida, Ryo Takita, Yoshio Kasashima, Masami Sakamoto, Takashi Mino
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Kilo-Scale Synthesis of the Dinucleotide DNA Methyltransferase Inhibitor Guadecitabine Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-05-10 Matthew Johnson, Ramakrishnan Chidambaram, Nipun Davar, Christian Madsen, Yogesh S. Sanghvi, Robert Short
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Process Intensification of the Continuous Synthesis of Bio-Derived Monomers for Sustainable Coatings Using a Taylor Vortex Flow Reactor Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-05-09 Matthew D. Edwards, Matthew T. Pratley, Charles M. Gordon, Rodolfo I. Teixeira, Hamza Ali, Irfhan Mahmood, Reece Lester, Ashley Love, Johannes G. H. Hermens, Thomas Freese, Ben L. Feringa, Martyn Poliakoff, Michael W. George
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Skeletal Rearrangement of Oxazole to Azepine and Pyrrole through Dynamic 8π Electrocyclizations Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Yi Tian, Lei Liu, Tu Zeng, Qian Wu, Baosheng Li
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Mechanosynthesis of Pyrrole-2-carboxylic Acids via Copper-Catalyzed Spiroannulation/Ring-Opening Aromatization of 4-Arylidene Isoxazol-5-ones with Enamino Esters Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Ming-Jun Li, Hui-Juan Xiao, Peng Xu, Luan-Ting Wu, Si-Qi Chen, Ze Zhang, Hui Xu
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Switchable Skeletal Rearrangement of Hexahydro-4H-indol-4-ones: Divergent Synthesis of Dihydroxy-4H-cyclopenta[b]pyridin-4-ones and 8-Alkenyl Oxepane-2,6-diones Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Zhilai Zhang, Haifeng Sun, Mingshuai Zhang, Siyu Song, Menglin Peng, Weifeng Dai, Yongchao Wang, Fuchao Yu
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Mechanochemical Vicinal Dibromination of Unactivated Alkenes and Alkynes Using Piezoelectric Material as a Redox Catalyst Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Fengzhi You, Xuemei Zhang, Xiaohong Wang, Guangqing Guo, Qingqing Wang, Hongzhuo Song, Ruiling Qu, Zhong Lian
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Aminosulfonylation of Alkenes for the Synthesis of β-Amino Sulfone Derivatives Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Hengyue Zhang, Xingda Zhao, Ruihan Yan, Weilong Lin
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Nickel-Catalyzed Electrophilic Amination of the Biphenylene C–C σ-Bond Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Takeru Inoue, Soshi Nishino, Kosuke Yasui, Koji Hirano
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Photoinduced Catalyst-Free Deuterodefunctionalization of Aryltriazenes with CDCl3 Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Bin Wang, Yang Shao, Ziren Chen, Yu Xia, Fei Xue, Weiwei Jin, Shaofeng Wu, Yonghong Zhang, Chenjiang Liu
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Synthesis of β,β-Dithioketones by Merging C–C and C–S Bond Cleavage in [1 + 1 + 1 + 1 + 1 + 1] Annulation Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Dong-Sheng Yang, Xiang-Long Chen, Chun-Yan Wu, Bo-Cheng Tang, Yong-Cheng Xiao, Yan-Dong Wu, An-Xin Wu
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Hydrophobic Surfactant–DNA Complex (Surf-DNA) Enables DNA-Encoded-Library-Compatible Decarboxylative Arylation under Anhydrous Conditions Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Pratik R. Chheda, Nicholas Simmons, Zhicai Shi
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Rh-Catalyzed α-Arylation of Cyclic 1,3-Dicarbonyls with Benzocyclobutenols Enabled by a Cyclic Iodonium Ylide Strategy Org. Lett. (IF 5.2) Pub Date : 2024-05-14 Borong Su, Zhenwei Zhang, Shangkun Zhang, Yao Zhou, Huaming Tao, Shaoyu Mai
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Entropy Effects in Temperature-Regulated Nickel-Catalyzed Regiodivergent Alkene Hydroalkylation Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-14 De-Guang Liu, Jia-Wang Wang, Xi Lu, Yao Fu
Temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation has been reported, yet there is a lack of a reasonable explanation for the regulation mechanism. Herein, we conduct a systematic analysis of the pertinent data, aiming to reveal the potential role and mechanism of temperature in regioselectivity. Alkyl radicals trapped by Ni(I) species are reasonably well-formed. Following
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Divergent synthesis of polythioindoles using elemental sulfur as the polysulfur source under metal-free conditions Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-14 Penghui Ni, Jing Tan, Yuxing Tan, Wujiu Jiang, Guo-Jun Deng
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Bromide-catalyzed oxo-amination of alkenes towards the synthesis of α-amine ketones under photoelectrocatalysis conditions Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-14 Zhi-Min Zong, Mingxu Wang, Xiao-Jing Zhao, Yonghui He
An efficient and novel bromide-catalyzed oxo-amination of aryl alkenes towards the synthesis of α-amine ketones using air as the oxygen source under electrophotocatalytic conditions was developed. The reaction was characterized by simple operation, a broad substrate scope, high atom economy, and mild reaction conditions. The mechanistic results suggested that the generation of 2-bromo-1-phenylethanone
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Visible-Light-Driven PCy3-promoted deselenization of 1,2-diselenides Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-14 Yi Liu, Fan Li, Miaochang Liu, Yun-Bing Zhou, Huayue Wu
Deselenization of 1,2-diselenides offers a promising tool for the construction of organochalcogenides. However, the requirement of transition metals and harsh reaction conditions are still significant challenges for this transformation. Herein, we have developed a metal-free and catalyst-free photocatalytic system for deselenization of 1,2-diselenides with PCy3, providing convenient access to monoselenides
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Chemodivergent (4 + 3) Cycloadditions of 2-Indolylmethanols with 1,3,5-Triazinanes: Access to Polycyclic Indoles Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-13 Rui Dong, Tian-Jiao Han, Lihua Huang, Guang-Jian Mei
Reported herein are the chemodivergent (4 + 3) cycloadditions of 2-indolylmethanols with 1,3,5-triazinanes. As opposed to the previous (3 + n) cycloadditions of 2-indolylmethanols as three-atom synthons, this divergent protocol employs 2-indolylmethanols as platform four-atom synthons by using the OH group as nucleophilic group. The gem-diaryl effect renders divergent regioselectivity. Primary 2-indolylmethanols
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Synthesis of Axially Chiral Biaryl-2-Carboxamides through Pd(II)-Catalyzed Atroposelective C−H Olefination Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-13 Boyang Jiang, Gang Zhou, Ao-Lian Jiang, Tao Zhou, Bing-Feng Shi
Herein, we developed a Pd(II)-catalyzed amide-directed atroposelective C−H olefination to the synthesis of axially chiral biaryls with N,N-disubstituted amide groups. A broad range of axially chiral biaryls were obtained in good to excellent yields and enantioselectivities (up to 96% yield and 99% ee) using cheap commercially (L)-Pyroglutamic acid (L-pGlu-OH) as a chiral ligand. Notably, the olefination
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Synthesis of heteroaryl C-glycosides via Ru-catalyzed C-H activation/cyclization: dioxazolones glycogen designs and applications Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-13 Xu-Ge Liu, Deng-Yin Liu, Peng-Fei Wang, Xin-Yue Hu, Yu-Jun Ruan, Xiao-Li Wang, Miao-Miao Wen, Cong-Zhen Zhang, Yu-He Xiao
New glycogen reagents of dioxazolones glycogen anomeric have been developed. The versatile heteroarene C-glycosides have been synthesized using a Ru-catalyzed C-H activation/annulation strategy, employing these dioxazolones glycogen anomeric. These reactions tolerate various saccharide donors and enable stereoselectivity synthesis of heterocyclic C-glycosides. The strategy and methods was well applicable
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Direct Dehydroxy(sulfhydryl)xanthylation of Alcohols and Thiols Org. Chem. Front. (IF 5.4) Pub Date : 2024-05-13 Dingjian Shan, Menglin Jiang, Fangcan Liang, Yu Zhong, Dianhu Zhu
Alkyl xanthates are broadly applied as synthetic intermediates for expedient access to a range of functional group derivatives in synthetic chemistry. Dehydroxyxanthylation of naturally rich alcohols represents a promising approach but has rarely been explored mainly due to the challenging activation mode. Herein, we report the direct dehydroxyxanthylation of a wide range of primary and secondary alcohols
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Visible‐Light‐Induced Oxidation of Silanes with SF6 for Efficient Synthesis of Siloxanes Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-14 Yu-Xiang Bi, Yue Zhao, Qing-Qing Zhang, Xiao-Yu Guo, Jing-Cheng Dai, Ruo-Xing Jin, Xi-Sheng Wang
A visible‐light‐induced strategy utilizing sulfur hexafluoride (SF6) as distinctive oxidant and water as the oxygen source to transform silanes into siloxanes has been developed under mild conditions, realizing the efficient utilization and degradation of the strong greenhouse gas, sulfur hexafluoride, simultaneously. Mechanistic experiments demonstrate that the reaction proceeds through a radical
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Electrochemical Decarboxylation/Mumm Rearrangement towards Imides Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-14 Ping Jiang, Chaoqiang Liang, Tianyu He, Rui Liu, Xiangtai Meng, Yu Zheng, Shenlin Huang
We report an electrochemically promoted decarboxylation of readily available carboxylic acid and subsequent Mumm rearrangement to synthesize the corresponding imides. The reaction features external oxidant‐free, transition metal‐free mild conditions, and good functional group tolerance, affording various imides in moderate to good yields. Mechanistic studies reveal that the selective oxidation of aliphatic
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Carbene-Catalyzed Atroposelective Construction of Chiral Diaryl Ethers J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Yuheng Liu, Lutong Yuan, Linlong Dai, Qiaohong Zhu, Guofu Zhong, Xiaofei Zeng
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Visible-Light-Promoted Radical Cascade Cyclization of 2-Vinyl Benzimidazoles: Access to Benzo[4,5]imidazo[1,2-b]isoquinolin- 11(6H)-ones J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Yao-Tian Wang, Mai Zhang, Zhi-Xing Liu, Yu-Xin Wu, Qian Yan, Cheng-Liang Liu, Jiang-Sheng Li, Zhi-Wei Li, Han-Wen Liu, Wen-Sheng Li
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ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Xuemei Wei, Tao Cai, Zhebing Zhang, Yanjuan Luo, Tianbo Shang, Hualiang Shen, Huiting Xu, Lemao Yu, Xiang Luo, Guoqi Yu, Runpu Shen
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Photoredox Synthesis of Silicon-Containing Isoindolin-1-ones and Deuterated Analogues Through Hydrosilylation and Deuterium-silylation J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Guo-Qin Wang, Yue Zhang, Yuan-Xia Zhou, Dan Yang, Pan Han, Lin-Hai Jing, Kai Tang
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Synthesis of 2-(Trifluoromethyl)-[1,2,4]triazolo[5,1-a]isoquinoline via Cycloaddition of C,N-Cyclic Azomethine Imine with CF3CN J. Org. Chem. (IF 3.6) Pub Date : 2024-05-09 Zhezuo Chen, Shouxiong Chen, Zhanyan Qiu, Bo Lin, Yunfei Yao, Fafu Yang, Zhiqiang Weng
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Chemoselective Hydrogenation of α,β-Unsaturated Ketones Catalyzed by a Manganese(I) Hydride Complex Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Kartick Dey, Graham de Ruiter
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Solvent-Switchable Remote C–H Activation via 1,4-Palladium Migration Enables Site-Selective C–P Bond Formation: A Tool for the Synthesis of P-Chiral Phosphinyl Imidazoles Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Ifenna I. Mbaezue, Shi-Guang Li, Angula C. S. Reddy, Hatem M. Titi, Youla S. Tsantrizos
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Copper-Catalyzed [3 + 2] Annulation of O-Acyl Oximes with 4-Sulfonamidophenols for the Synthesis of 5-Sulfonamidoindoles and 2-Amido-5-sulfonamidobenzofuran-3(2H)-ones Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Zi-Jun Hu, Wei Chen, Xinyu Lyu, Hui-Peng Zhang, Si-Wei Chen, Xian-Heng Ding, Cang-Hai Yu, Zhen Cui, Chun-Bao Miao, Hai-Tao Yang
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Organic Dye Photocatalyzed Synthesis of Functionalized Lactones and Lactams via a Cyclization–Alkynylation Cascade Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Diana Cavalli, Jerome Waser
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Synthesis of N-Glyoxylyl Peptides Enabled by a Lossen Rearrangement-Induced Intramolecular Redox Reaction of N-Terminal Glycyl Hydroxamic Acid Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Junya Hayashi, Daishiro Kobayashi, Chizuru Namikawa, Masaya Denda, Akira Otaka
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Three-Component Assembly of Dihydropyrrolo[3,4-e][1,3]thiazines from Elemental Sulfur, Maleimides, and 1,3,5-Triazinanes Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Wen-Kang Wang, Fei-Yun Bao, Zhi-Wei Shang, Jian Zheng, Sheng-Yin Zhao
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Decarboxylative Nucleophilic Fluorination of Aliphatic Carboxylic Acids Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Qian Yu, Donglin Zhou, Junjun Ma, Chunlan Song
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N-Oxide-to-Carbon Transmutations of Azaarene N-Oxides Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Nicholas A. Falcone, Sam He, John F. Hoskin, Sandeep Mangat, Erik J. Sorensen
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Conversion of Phorbol into Des-D-Ring Tricycle and Crotonianoid B via Peroxidation Reaction Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Ayumu Watanabe, Yuto Hikone, Masanori Nagatomo, Masayuki Inoue
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Solvent-Driven Room-Temperature Curtius Rearrangements to Access Nucleotides Bearing Substituted Fused Pyridones Org. Lett. (IF 5.2) Pub Date : 2024-05-13 Gongming Zhu, Haiyang Zhang, Liyang Han, Honglei Wang, Anlian Zhu, Lingjun Li
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Bis(bicyclo[1.1.1]pentyl)chlorophosphine as a Precursor for the Preparation of Bis(bicyclo[1.1.1]pentyl)phosphines Org. Lett. (IF 5.2) Pub Date : 2024-05-12 Griffin L. Perry, Nathan D. Schley
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Pd-Catalyzed Enantioselective Desymmetrizing 1,7-Enyne Cycloisomerization of Alkyne-Tethered Cyclopentenes Org. Lett. (IF 5.2) Pub Date : 2024-05-12 Ren-Xiao Liang, Chao Ding, Hu-Jie Cai, Jia-Yi Wang, Qi-Chuang Li, Gao-Yang Yu, Yi-Xia Jia
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Cyclization Reactions of 1,5-Diynes: Mechanisms and the Role of the Central Linker Org. Lett. (IF 5.2) Pub Date : 2024-05-12 Farshad Shiri, Zhenyang Lin
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Cyclic Sesquiterpene–Flavanone [4+2] Hybrids, Syzygioblanes A–C, Found in an Indonesian Traditional Medicine, “Jampu Salo” (Syzygium oblanceolatum) Org. Lett. (IF 5.2) Pub Date : 2024-05-10 Nona Koga, Yohei Saito, Katsunori Miyake, Saidanxia Amuti, Shuichi Fukuyoshi, Satoshi Yoshida, Sota Sato, Yusuke Yamada, Akihito Ikeda, Naruhiko Adachi, Masato Kawasaki, Akira Takasu, Shinji Aramaki, Toshiya Senda, Abdul Rahim, Ahmad Najib, Gemini Alam, Nobuyuki Tanaka, Kyoko Nakagawa-Goto
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Electrochemically‐Enabled Construction of N‐Acyl Iminophosphoranes Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-13 Wei Wang, Shujie Cao, Yike Wang, Boxin Hu, Xuehua Zhu, Yanyan Sun, Yang Wang
N‐acyl iminophosphoranes have shown significant potentials in various areas. This paper presents two electrochemical strategies for the successful construction of a series of substituted N‐acyl iminophosphoranes using electrochemical activation of hydroxylamines or dioxazolones to generate unprotected amide radicals and radical anions. The simple undivided cell with inexpensive electrode setups (graphite
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Photoinduced Remote Selective C(sp3)‐H Alkylation Mediated by Cesium formate Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-13 Vijay Kumar Simhadri, Rupam Sur, Veera Reddy Yatham
Herein, we developed a photoinduced remote selective C(sp3)−H alkylation of protected amines in the presence of cesium formate. The protected amines were synthesized from commercially available inexpensive 2‐iodo benzoyl chloride. Under mild reaction conditions, the in situ generated aryl radical is converted to alpha‐amidoalkyl radical via [1,5]‐HAT process, which combines with different Michael acceptors
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Imidazolium Dicyanomethylides as N‐Ylide Precursors of Anionic N‐Heterocyclic Carbenes Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-13 Sean Ray Kahnert, Jan C. Namyslo, Kari Rissanen, Martin Nieger, Andreas Schmidt
In the past, the use of nitrogen ylides focused primarily on cycloadditions, where the 1,3‐dipole was used as a building block for the formation of heterocycles such as pyrroles or pyrrolinones. In this work, we present a new perspective on imidazolium dicyanomethylides with their synthesis and utilization as anionic N‐heterocyclic carbenes (NHCs). The values of relative carbene formation energies
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Towards the Stable Binding of Mercury: Synthesis and Functionalization of Dibenzyldiazabicyclononane Scaffolds Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-13 Toni Weber, Tobias Krönke, Martin Köckerling, Martin Walther, Hans-Jürgen Pietzsch, Klaus Kopka, Constantin Mamat
A universally applicable synthesis route for the preparation of functionalized diazabicyclononane compounds was elaborated starting from a readily available 1,5‐diphenyl‐3,7‐diazabicyclo[3.3.1] nonan‐9‐ol by alkylation of both secondary amines with modified benzyl residues containing a bromo, trimethylstannyl, trimethylsilyl, and pinacolboranyl residue. High yields (65‐88%) were achieved, supporting
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4‐Methyltetrahydropyran: a Versatile Alternative Solvent for the Preparation of Chiral BINOL Catalysts and the Asymmetric Alkylation of Aldehydes Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-13 Francesco Marra, Federica De Nardi, Federica Rossi, Emanuele Priola, Cristina Prandi, Marco Blangetti
We herein report that the highly hydrophobic ether 4‐MeTHP constitutes a promising resource for the development of sustainable synthetic methodologies grounded on the use of organometallic reagents. The beneficial effects of 4‐MeTHP as reaction media are illustrated in the organolithium‐promoted anionic ortho‐Fries rearrangement of 1,1’‐bi‐2‐naphthol (BINOL)‐based carbamates under bench‐type conditions
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EDA Complex from BCP‐Thianthrenium Salt: A Catalyst‐free Strategy To Access 1‐Trifluoromethyl‐3‐quinoxaline Derivatives Bicyclo[1.1.1]pentanes Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-05-13 Guofu Zhang, Zijin Luo, Guangyao Mei, Haibo Wang, Chengrong Ding
: The construction of bicyclo[1.1.1.]pentanes (BCPs) typically require the cumbersome use of labile [1.1.1.]propellane in solution and involve multicomponent radical reactions, which commonly produce undesired by‐products that hinder the efficient construction of BCPs. In this paper, we present a catalyst‐free strategy by constructing an electron donor‐acceptor (EDA) complex utilizing the naturally
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