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Antibodies expand the scope of angiotensin receptor pharmacology Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-14 Meredith A. Skiba, Sarah M. Sterling, Shaun Rawson, Shuhao Zhang, Huixin Xu, Haoran Jiang, Genevieve R. Nemeth, Morgan S. A. Gilman, Joseph D. Hurley, Pengxiang Shen, Dean P. Staus, Jihee Kim, Conor McMahon, Maria K. Lehtinen, Howard A. Rockman, Patrick Barth, Laura M. Wingler, Andrew C. Kruse
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The β-subunit of tryptophan synthase is a latent tyrosine synthase Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-14 Patrick J. Almhjell, Kadina E. Johnston, Nicholas J. Porter, Jennifer L. Kennemur, Vignesh C. Bhethanabotla, Julie Ducharme, Frances H. Arnold
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RNA-based programmable DNA cleavage Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-10 Madeleine B. King, Audrone Lapinaite
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Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-08 Zhe Li, Zhi-min Xu, Wei-peng Chen, Xiao-jing Du, Chun-xian Ou, Zi-kang Luo, Rong Wang, Chu-qing Zhang, Chao-dong Ge, Meng Han, Fudi Wang, Rong-Rong He, Wan-yang Sun, Jun Ma, Xiao-yu Liang, Zhuo-wei Liu
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Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-06
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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-03 Hui Yang, Dinshaw J. Patel
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Engineering from evolution Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Francesco Zamberlan
Polyketides are a group of natural products with valuable pharmacological activities, biosynthesized by bacterial or fungal megaenzymes called polyketide synthases (PKSs). These are composed of multiple modules in an assembly line, each introducing a specific moiety of the final compound in a stepwise manner. Among them, trans-acyltransferase PKSs have evolved through the recombination of biosynthetic
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Bacteria lose a pep in their step Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Gene Chong
Zhang et al. hypothesized that a structurally similar disaccharide, GlcNAc-1,6-anhydro-MurNAc, could be a minimal moiety that acts as a competitive inhibitor to lipid II and lacks a reducing end for glycan chain elongation. The authors developed a 15-step total synthesis of the disaccharide-pentapeptide unit, called compound 1, and the disaccharide-only compound, 1-deAA. They incubated compound 1 with
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Setting the pace for degrons Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Yiyun Song
Immunomodulatory drugs (IMiDs), including thalidomide, pomalidomide and lenalidomide, act as molecular glues to induce the ubiquitination and degradation of their target proteins (referred to as neosubstrates) by facilitating their direct interaction with cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. Some neosubstrates contain a C2H2 zinc finger motif that is responsible
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Chris A. Brosey, Todd M. Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L. Hura, Darin E. Jones, John A. Tainer
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Pyro(phospho)mania Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Claire E. Eyers, Christopher J. Clarke
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Minimizing higher-order aggregation maximizes iron mobilization by small molecules Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Andrew D. Blake, Jianhua Chao, Anna M. SantaMaria, Stella Ekaputri, Kelsie J. Green, Samantha T. Brown, Christopher K. Rakowski, Eun-Kyung Choi, Luisa Aring, Peng-Jui Chen, Nicholas M. Snead, Douglas M. Matje, Tao Geng, Angela Octaviani, Keith Bailey, Stanley J. Hollenbach, Timothy M. Fan, Young-Ah Seo, Martin D. Burke
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Extensive protein pyrophosphorylation revealed in human cell lines Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Jeremy A. M. Morgan, Arpita Singh, Leonie Kurz, Michal Nadler-Holly, Max Ruwolt, Shubhra Ganguli, Sheenam Sharma, Martin Penkert, Eberhard Krause, Fan Liu, Rashna Bhandari, Dorothea Fiedler
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Structural basis for α-tubulin-specific and modification state-dependent glutamylation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-24 Kishore K. Mahalingan, Danielle A. Grotjahn, Yan Li, Gabriel C. Lander, Elena A. Zehr, Antonina Roll-Mecak
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Molecular recording of calcium signals via calcium-dependent proximity labeling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-24 J. Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Joseph H. Lobel, Wei Wang, Ted M. Dawson, Valina L. Dawson, Ruixuan Gao, Yuh Nung Jan, Helen S. Bateup, Nicholas T. Ingolia
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Addendum: Designing microbial consortia with defined social interactions Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-22 Wentao Kong, James J. Collins, Ting Lu
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UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-22 Tian Tian, Junliang Chen, Huacun Zhao, Yulin Li, Feiyu Xia, Jun Huang, Jinhua Han, Ting Liu
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A peptide dehydratase with core strength Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-19 Daniel Richter, Anna Lisa Vagstad
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Forced rewiring of RTK signaling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-18 Ahsan Ausaf Ali, Mahmoud Amouzadeh Tabrizi, Mingxu You
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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-17 Robert I. Horne, Ewa A. Andrzejewska, Parvez Alam, Z. Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C. Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P. J. Knowles, Michele Vendruscolo
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Bringing chemistry to medicine to redefine the undruggable Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-12 Caitlin D. Deane, Marcus Fischer, Anang A. Shelat
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Peptide vaccines get an OS update Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-05 Martin Zacharias, Sebastian Springer
Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short half-life of peptides. A study now reports thioamide substitution in the peptide backbone as a strategy to enhance resistance to proteolysis and promote binding to the MHC I complex for T cell activation.
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LPS gets a fresh trim Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-01 Gemma Banister, Dave Boucher
Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome. ATGL has now been identified as a negative regulator of this pathway that dampens inflammation by removing LPS’ acyl chains, preventing the activation of inflammatory caspases and cytokines.
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Engineering APOBEC3A deaminase for highly accurate and efficient base editing Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-29 Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li
Cytosine base editors (CBEs) are effective tools for introducing C-to-T base conversions, but their clinical applications are limited by off-target and bystander effects. Through structure-guided engineering of human APOBEC3A (A3A) deaminase, we developed highly accurate A3A-CBE (haA3A-CBE) variants that efficiently generate C-to-T conversion with a narrow editing window and near-background level of
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Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-27 Min Li, Zheng Wang, Jingjing Tao, Hongfei Jiang, Huang Yang, Dong Guo, Hong Zhao, Xuxiao He, Shudi Luo, Xiaoming Jiang, Li Yuan, Liwei Xiao, Haiyan He, Rilei Yu, Jing Fang, Tingbo Liang, Zhengwei Mao, Daqian Xu, Zhimin Lu
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The death gaze of MEDUSA Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-26 Jesse D. Gelles, Jerry Edward Chipuk
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Reeling in microorganisms Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Gene Chong
The metabolic engineering of microorganisms is an attractive platform for bioremediation and the industrial production of chemicals. However, biocontainment strategies are needed if genetically modified organisms are to be released into open environments. Hoffmann and Cai report a biocontainment strategy in yeast based on targeted protein degradation. The authors performed high-throughput screening
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Profiling the proximal proteome of the activated μ-opioid receptor Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Prachi Khare, Matthew K. Howard, Alberto J. Gonzalez-Hernandez, Jiewei Xu, Qiongyu Li, Brandon Novy, Zun Zar Chi Naing, Brian K. Shoichet, Willow Coyote-Maestas, Joshua Levitz, Nevan J. Krogan, Mark Von Zastrow, Ruth Hüttenhain
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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A. Cordova, Frederick N. Petroze, Ramya Srinivasan, Kevin C. Allan, David F. Yan, Joel L. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B. Desai, Drew J. Adams
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Stress it up Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Grant Miura
AKT is a serine/threonine kinase that is essential for cellular metabolism and proliferation and is overactive in cancer cells. Small molecule catalytic inhibitors of all three AKT isoforms, as well as selective AKT degraders, have been developed, but the therapeutic efficacy of these compounds remains less than optimal. In particular, existing AKT degraders such as INY-03-041 elicit slow degradation
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Switching off the stress response Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Yiyun Song
Cells respond to adverse environmental changes by activating stress response pathways. However, the continuous activation of stress responses can lead to unwanted cell death or damage to necessary biological functions, and it is not clear how stress response pathways are turned off once the condition improves. Haakonsen et al. have now reported the discovery of an E3 complex that switches off the stress
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Global signal peptide profiling reveals principles of selective Sec61 inhibition Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-22 Nicole A. Wenzell, Brian B. Tuch, Dustin L. McMinn, Matthew J. Lyons, Christopher J. Kirk, Jack Taunton
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Sulfide oxidation promotes hypoxic angiogenesis and neovascularization Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-20 Roshan Kumar, Victor Vitvitsky, Apichaya Sethaudom, Rashi Singhal, Sumeet Solanki, Sydney Alibeckoff, Harrison L. Hiraki, Hannah N. Bell, Anthony Andren, Brendon M. Baker, Costas A. Lyssiotis, Yatrik M. Shah, Ruma Banerjee
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Ripping and stitching with copper Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-21 Ninian J. Blackburn
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Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-21 Hai-Tsang Huang, Ryan J. Lumpkin, Ryan W. Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine A. Donovan, Eric S. Fischer, William R. Sellers
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Design of amyloidogenic peptide traps Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-19 Danny D. Sahtoe, Ewa A. Andrzejewska, Hannah L. Han, Enrico Rennella, Matthias M. Schneider, Georg Meisl, Maggie Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K. Bera, Lewis E. Kay, Tuomas P. J. Knowles, David Baker
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Accessing natural vaccine adjuvants Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-15 Vincent Courdavault, Nicolas Papon
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Functional genomic screens with death rate analyses reveal mechanisms of drug action Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-13 Megan E. Honeywell, Marie S. Isidor, Nicholas W. Harper, Rachel E. Fontana, Gavin A. Birdsall, Peter Cruz-Gordillo, Sydney A. Porto, Madison Jerome, Cameron S. Fraser, Kristopher A. Sarosiek, David A. Guertin, Jessica B. Spinelli, Michael J. Lee
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De novo-designed transmembrane proteins bind and regulate a cytokine receptor Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-13 Marco Mravic, Li He, Huong T. Kratochvil, Hailin Hu, Sarah E. Nick, Weiya Bai, Anne Edwards, Hyunil Jo, Yibing Wu, Daniel DiMaio, William F. DeGrado
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Breaking the deadlock in genetic code expansion Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-11 Ya-Ming Hou, Yuko Nakano
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A solid beta-sheet structure is formed at the surface of FUS droplets during aging Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-11 Leonidas Emmanouilidis, Ettore Bartalucci, Yelena Kan, Mahdiye Ijavi, Maria Escura Pérez, Pavel Afanasyev, Daniel Boehringer, Johannes Zehnder, Sapun H. Parekh, Mischa Bonn, Thomas C. T. Michaels, Thomas Wiegand, Frédéric H.-T. Allain
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Aerobic glycolysis comes with an enzyme cost but robustness gain Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-08
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DNA-functionalized artificial mechanoreceptor for de novo force-responsive signaling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-06 Sihui Yang, Miao Wang, Dawei Tian, Xiaoyu Zhang, Kaiqing Cui, Shouqin Lü, Hong-hui Wang, Mian Long, Zhou Nie
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Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-08 Matthieu Schapira, Levon Halabelian, Cheryl H. Arrowsmith, Rachel J. Harding
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Hijacking endogenous mRNA for genetic code expansion Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-07 Tomohiro Doura, Yuma Matsuoka, Shigeki Kiyonaka
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Mitochondrial ATP generation is more proteome efficient than glycolysis Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-06 Yihui Shen, Hoang V. Dinh, Edward R. Cruz, Zihong Chen, Caroline R. Bartman, Tianxia Xiao, Catherine M. Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I. Hendry, Vinh G. Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D. Maranas, Martin Wühr, Joshua D. Rabinowitz
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Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-05 Qinheng Zheng, Ziyang Zhang, Keelan Z. Guiley, Kevan M. Shokat
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Friend or foe-maldehyde Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-29 Vicki L. Emms, Sara Y. Chothia, Richard J. Hopkinson
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In situ analysis of osmolyte mechanisms of proteome thermal stabilization Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-29 Monika Pepelnjak, Britta Velten, Nicolas Näpflin, Tatjana von Rosen, Umberto Capasso Palmiero, Jeong Hoon Ko, Heather D. Maynard, Paolo Arosio, Eilika Weber-Ban, Natalie de Souza, Wolfgang Huber, Paola Picotti
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Antiviral drug recognition and elevator-type transport motions of CNT3 Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-28 Nicholas J. Wright, Feng Zhang, Yang Suo, Lingyang Kong, Ying Yin, Justin G. Fedor, Kedar Sharma, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee
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Programmable RNA base editing via targeted modifications Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-28 Jinghui Song, Yuan Zhuang, Chengqi Yi
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Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-27 Weitao Li, Qiannv Liu, Yan Qian, Chunlei Wang, Chun Kong, Liangliang Sun, Li Sun, Hongwei Liu, Yan Zhang, Dong Jiang, Changtao Jiang, Shuo Wang, Pengyan Xia
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Discovery of metal-binding proteins by thermal proteome profiling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-26 Xin Zeng, Tiantian Wei, Xianghe Wang, Yuan Liu, Zhenshu Tan, Yihai Zhang, Tianyu Feng, Yao Cheng, Fengzhang Wang, Bin Ma, Wei Qin, Chuanping Gao, Junyu Xiao, Chu Wang
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Lights on for lipid metabolism Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-21 Francesco Zamberlan
Phosphatidic acid is a pleiotropic lipid involved in lipid transport across different cellular organelles as well as major cellular signaling pathways through its metabolism. However, understanding and mapping its physiological functions require methods that can detect its rapid spatial concentration changes. Optogenetic membrane editors based on the biosynthesis of phosphatidic acid using phospholipase
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A tale of two lipids Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-21 Gene Chong
Original reference: ACS Chem. Biol. https://doi.org/10.1021/acschembio.3c00554 (2024)
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Death pools Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-21 Grant Miura
Original reference: Mol. Cell https://doi.org/10.1016/j.molcel.2023.12.041 (2024)
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The druggability of SH2 domains unmasked Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-15 Oliver Hantschel