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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23 Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Danilo Segovia, Dexter W. Adams, Nickolas Hoffman, Polona Safaric Tepes, Tse-Luen Wee, Paolo Cifani, Leemor Joshua-Tor, Adrian R. Krainer
SRSF1 is the founding member of the SR protein family. It is required—interchangeably with other SR proteins—for pre-mRNA splicing in vitro, and it regulates various alternative splicing events. Dysregulation of SRSF1 expression contributes to cancer and other pathologies. Here, we characterized SRSF1’s interactome using proximity labeling and mass spectrometry. This approach yielded 190 proteins enriched
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Lipid-derived electrophiles inhibit the function of membrane channels during ferroptosis Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Antonius T. M. Van Kessel, Gonzalo Cosa
The therapeutic targeting of ferroptosis requires full understanding of the molecular mechanism of this regulated cell death pathway. While lipid-derived electrophiles (LDEs), including 4-hydroxy-2-nonenal (4-HNE), are important biomarkers of ferroptosis, a functional role for these highly reactive species in ferroptotic cell death execution has not been established. Here, through mechanistic characterization
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Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Joseph J. Braymer, Oliver Stehling, Martin Stümpfig, Ralf Rösser, Farah Spantgar, Catharina M. Blinn, Ulrich Mühlenhoff, Antonio J. Pierik, Roland Lill
The biogenesis of iron–sulfur (Fe/S) proteins entails the synthesis and trafficking of Fe/S clusters, followed by their insertion into target apoproteins. In eukaryotes, the multiple steps of biogenesis are accomplished by complex protein machineries in both mitochondria and cytosol. The underlying biochemical pathways have been elucidated over the past decades, yet the mechanisms of cytosolic [2Fe-2S]
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Dichotomous dynamics of magnetic monopole fluids Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Chun-Chih Hsu, Hiroto Takahashi, Fabian Jerzembeck, Jahnatta Dasini, Chaia Carroll, Ritika Dusad, Jonathan Ward, Catherine Dawson, Sudarshan Sharma, Graeme M. Luke, Stephen J. Blundell, Claudio Castelnovo, Jonathan N. Hallén, Roderich Moessner, J. C. Séamus Davis
A recent advance in the study of emergent magnetic monopoles was the discovery that monopole motion is restricted to dynamical fractal trajectories [J. N. Hallén et al. , Science 378 , 1218 (2022)], thus explaining the characteristics of magnetic monopole noise spectra [R. Dusad et al., Nature 571 , 234 (2019); A. M. Samarakoon et al. , Proc. Natl. Acad. Sci. U.S.A. 119 , e2117453119 (2022)]. Here
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Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 John R. Ferrarone, Jerin Thomas, Arun M. Unni, Yuxiang Zheng, Michal J. Nagiec, Eric E. Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C. Cantley, John Blenis, Neville E. Sanjana, Harold Varmus
The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell polarity and metabolism; however, the pathways that mediate the tumor-suppressive activity of LKB1 are incompletely defined. To identify mechanisms of LKB1-mediated growth suppression, we developed a spheroid-based
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A fungal protein organizes both glycogen and cell wall glucans Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Liza Loza, Tamara L. Doering
Glycogen is a glucose storage molecule composed of branched α-1,4-glucan chains, best known as an energy reserve that can be broken down to fuel central metabolism. Because fungal cells have a specialized need for glucose in building cell wall glucans, we investigated whether glycogen is used for this process. For these studies, we focused on the pathogenic yeast Cryptococcus neoformans , which causes
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Dark continuous noise from mutant G90D-rhodopsin predominantly underlies congenital stationary night blindness Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Zuying Chai, Yaqing Ye, Daniel Silverman, Kasey Rose, Alana Madura, Randall R. Reed, Jeannie Chen, King-Wai Yau
Congenital stationary night blindness (CSNB) is an inherited retinal disease that causes a profound loss of rod sensitivity without severe retinal degeneration. One well-studied rhodopsin point mutant, G90D-Rho, is thought to cause CSNB because of its constitutive activity in darkness causing rod desensitization. However, the nature of this constitutive activity and its precise molecular source have
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Bacterial lifestyle shapes pangenomes Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Anna E. Dewar, Chunhui Hao, Laurence J. Belcher, Melanie Ghoul, Stuart A. West
Pangenomes vary across bacteria. Some species have fluid pangenomes, with a high proportion of genes varying between individual genomes. Other species have less fluid pangenomes, with different genomes tending to contain the same genes. Two main hypotheses have been suggested to explain this variation: differences in species’ bacterial lifestyle and effective population size. However, previous studies
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Identification and characterization of a nonbiological small-molecular mimic of a Zika virus conformational neutralizing epitope Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Priscila M. S. Castanha, Patrick J. McEnaney, Yongseok Park, Anthea Bouwer, Elton J. F. Chaves, Roberto D. Lins, Nicholas G. Paciaroni, Paige Dickson, Graham Carlson, Marli T. Cordeiro, Tereza Magalhaes, Jodi Craigo, Ernesto T. A. Marques, Thomas Kodadek, Donald S. Burke
Antigenic similarities between Zika virus (ZIKV) and other flaviviruses pose challenges to the development of virus-specific diagnostic tools and effective vaccines. Starting with a DNA-encoded one-bead-one-compound combinatorial library of 508,032 synthetic, non-natural oligomers, we selected and characterized small molecules that mimic ZIKV epitopes. High-throughput fluorescence-activated cell sorter-based
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Microbes vary strategically in their metalation of mononuclear enzymes Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Sanjay Kumar Rohaun, Ramakrishnan Sethu, James A. Imlay
Studies have determined that nonredox enzymes that are cofactored with Fe(II) are the most oxidant-sensitive targets inside Escherichia coli . These enzymes use Fe(II) cofactors to bind and activate substrates. Because of their solvent exposure, the metal can be accessed and oxidized by reactive oxygen species, thereby inactivating the enzyme. Because these enzymes participate in key physiological
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ZEPPI: Proteome-scale sequence-based evaluation of protein–protein interaction models Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-14 Haiqing Zhao, Donald Petrey, Diana Murray, Barry Honig
We introduce ZEPPI (Z-score Evaluation of Protein–Protein Interfaces), a framework to evaluate structural models of a complex based on sequence coevolution and conservation involving residues in protein–protein interfaces. The ZEPPI score is calculated by comparing metrics for an interface to those obtained from randomly chosen residues. Since contacting residues are defined by the structural model
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The physical and evolutionary energy landscapes of devolved protein sequences corresponding to pseudogenes Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Hana Jaafari, Carlos Bueno, Nicholas P. Schafer, Jonathan Martin, Faruck Morcos, Peter G. Wolynes
Protein evolution is guided by structural, functional, and dynamical constraints ensuring organismal viability. Pseudogenes are genomic sequences identified in many eukaryotes that lack translational activity due to sequence degradation and thus over time have undergone “devolution.” Previously pseudogenized genes sometimes regain their protein-coding function, suggesting they may still encode robust
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Seabirds reveal mercury distribution across the North Atlantic Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Céline Albert, Børge Moe, Hallvard Strøm, David Grémillet, Maud Brault-Favrou, Arnaud Tarroux, Sébastien Descamps, Vegard Sandøy Bråthen, Benjamin Merkel, Jens Åström, Françoise Amélineau, Frédéric Angelier, Tycho Anker-Nilssen, Olivier Chastel, Signe Christensen-Dalsgaard, Johannis Danielsen, Kyle Elliott, Kjell Einar Erikstad, Alexey Ezhov, Per Fauchald, Geir W. Gabrielsen, Maria Gavrilo, Sveinn
Mercury (Hg) is a heterogeneously distributed toxicant affecting wildlife and human health. Yet, the spatial distribution of Hg remains poorly documented, especially in food webs, even though this knowledge is essential to assess large-scale risk of toxicity for the biota and human populations. Here, we used seabirds to assess, at an unprecedented population and geographic magnitude and high resolution
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Premeiotic 24-nt phasiRNAs are present in the Zea genus and unique in biogenesis mechanism and molecular function Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Junpeng Zhan, Sébastien Bélanger, Scott Lewis, Chong Teng, Madison McGregor, Aleksandra Beric, Michael A. Schon, Michael D. Nodine, Blake C. Meyers
Reproductive phasiRNAs (phased, small interfering RNAs) are broadly present in angiosperms and play crucial roles in sustaining male fertility. While the premeiotic 21-nt (nucleotides) phasiRNAs and meiotic 24-nt phasiRNA pathways have been extensively studied in maize ( Zea mays ) and rice ( Oryza sativa ), a third putative category of reproductive phasiRNAs–named premeiotic 24-nt phasiRNAs–have recently
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Mimicking natural deterrent strategies in plants using adhesive spheres Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Ralph van Zwieten, Thijs V. Bierman, Peter G. L. Klinkhamer, T. Martijn Bezemer, Klaas Vrieling, Thomas E. Kodger
With a continuous increase in world population and food production, chemical pesticide use is growing accordingly, yet unsustainably. As chemical pesticides are harmful to the environment and developmental resistance in pests is increasing, a sustainable and effective pesticide alternative is needed. Inspired by nature, we mimic one defense strategy of plants, glandular trichomes, to shift away from
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Southern Ocean drives multidecadal atmospheric CO 2 rise during Heinrich Stadials Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Kathleen A. Wendt, Christoph Nehrbass-Ahles, Kyle Niezgoda, David Noone, Michael Kalk, Laurie Menviel, Julia Gottschalk, James W. B. Rae, Jochen Schmitt, Hubertus Fischer, Thomas F. Stocker, Juan Muglia, David Ferreira, Shaun A. Marcott, Edward Brook, Christo Buizert
The last glacial period was punctuated by cold intervals in the North Atlantic region that culminated in extensive iceberg discharge events. These cold intervals, known as Heinrich Stadials, are associated with abrupt climate shifts worldwide. Here, we present CO 2 measurements from the West Antarctic Ice Sheet Divide ice core across Heinrich Stadials 2 to 5 at decadal-scale resolution. Our results
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Extreme elevational migration spurred cryptic speciation in giant hummingbirds Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Jessie L. Williamson, Ethan F. Gyllenhaal, Selina M. Bauernfeind, Emil Bautista, Matthew J. Baumann, Chauncey R. Gadek, Peter P. Marra, Natalia Ricote, Thomas Valqui, Francisco Bozinovic, Nadia D. Singh, Christopher C. Witt
The ecoevolutionary drivers of species niche expansion or contraction are critical for biodiversity but challenging to infer. Niche expansion may be promoted by local adaptation or constrained by physiological performance trade-offs. For birds, evolutionary shifts in migratory behavior permit the broadening of the climatic niche by expansion into varied, seasonal environments. Broader niches can be
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The GPAT4 / 6 / 8 clade functions in Arabidopsis root suberization nonredundantly with the GPAT5/7 clade required for suberin lamellae Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Kay Gully, Alice Berhin, Damien De Bellis, Cornelia Herrfurth, Ivo Feussner, Christiane Nawrath
Lipid polymers such as cutin and suberin strengthen the diffusion barrier properties of the cell wall in specific cell types and are essential for water relations, mineral nutrition, and stress protection in plants. Land plant–specific glycerol-3-phosphate acyltransferases (GPATs) of different clades are central players in cutin and suberin monomer biosynthesis. Here, we show that the GPAT4 / 6 / 8
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The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Mengzhu Chai, Lei Li, Yong Li, Yingshuai Yang, Yuting Wang, Xue Jiang, Yameng Luan, Fangfang Li, Hongguang Cui, Aiming Wang, Wensheng Xiang, Xiaoyun Wu, Xiaofei Cheng
Potyviridae, the largest family of plant RNA viruses, includes many important pathogens that significantly reduce the yields of many crops worldwide. In this study, we report that the 6-kilodalton peptide 1 (6K1), one of the least characterized potyviral proteins, is an endoplasmic reticulum–localized protein. AI–assisted structure modeling and biochemical assays suggest that 6K1 forms pentamers with
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Exploring the activation mechanism of metabotropic glutamate receptor 2 Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Xiaohong Zhu, Mengqi Luo, Ke An, Danfeng Shi, Tingjun Hou, Arieh Warshel, Chen Bai
Homomeric dimerization of metabotropic glutamate receptors (mGlus) is essential for the modulation of their functions and represents a promising avenue for the development of novel therapeutic approaches to address central nervous system diseases. Yet, the scarcity of detailed molecular and energetic data on mGlu2 impedes our in-depth comprehension of their activation process. Here, we employ computational
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Crop yields fail to rise in smallholder farming systems in sub-Saharan Africa Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Philip Wollburg, Thomas Bentze, Yuchen Lu, Christopher Udry, Douglas Gollin
Drawing on a harmonized longitudinal dataset covering more than 55,000 smallholder farms in six African countries, we analyze changes in crop productivity from 2008 to 2019. Because smallholder farmers represent a significant fraction of the world’s poorest people, agricultural productivity in this context matters for poverty reduction and for the broader achievement of the UN Sustainable Development
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Inflation in 2022 did not affect congressional voting, but abortion did Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Diana C. Mutz, Edward D. Mansfield
This study examines voting in the 2022 United States congressional elections, contests that were widely expected to produce a sizable defeat for Democratic candidates for largely economic reasons. Based on a representative national probability sample of voters interviewed in both 2020 and 2022, individuals who changed their vote from one party's congressional candidate to another party’s candidate
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The effects of Facebook and Instagram on the 2020 election: A deactivation experiment Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Hunt Allcott, Matthew Gentzkow, Winter Mason, Arjun Wilkins, Pablo Barberá, Taylor Brown, Juan Carlos Cisneros, Adriana Crespo-Tenorio, Drew Dimmery, Deen Freelon, Sandra González-Bailón, Andrew M. Guess, Young Mie Kim, David Lazer, Neil Malhotra, Devra Moehler, Sameer Nair-Desai, Houda Nait El Barj, Brendan Nyhan, Ana Carolina Paixao de Queiroz, Jennifer Pan, Jaime Settle, Emily Thorson, Rebekah Tromble
We study the effect of Facebook and Instagram access on political beliefs, attitudes, and behavior by randomizing a subset of 19,857 Facebook users and 15,585 Instagram users to deactivate their accounts for 6 wk before the 2020 U.S. election. We report four key findings. First, both Facebook and Instagram deactivation reduced an index of political participation (driven mainly by reduced participation
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Reduced stress propagation leads to increased mechanical failure resistance in auxetic materials Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Suzanne M. Fielding
Materials with a negative Poisson ratio have the counterintuitive property of expanding laterally when they are stretched longitudinally. They are accordingly termed auxetic, from the Greek auxesis meaning to increase. Experimental studies have demonstrated auxetic materials to have superior material properties, compared with conventional ones. These include synclastic curvature, increased acoustic
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The modern human aryl hydrocarbon receptor is more active when ancestralized by genome editing Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Nelly Helmbrecht, Martin Lackner, Tomislav Maricic, Svante Pääbo
The aryl hydrocarbon receptor (AHR) is a transcription factor that has many functions in mammals. Its best known function is that it binds aromatic hydrocarbons and induces the expression of cytochrome P450 genes, which encode enzymes that metabolize aromatic hydrocarbons and other substrates. All present-day humans carry an amino acid substitution at position 381 in the AHR that occurred after the
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PM 2.5 exposure contributes to anxiety and depression-like behaviors via phenyl-containing compounds interfering with dopamine receptor Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Shaoyang Ji, Yuqiong Guo, Wei Yan, Fang Wei, Jinjian Ding, Wenjun Hong, Xiaoyun Wu, Tingting Ku, Huifeng Yue, Nan Sang
As a global problem, fine particulate matter (PM 2.5 ) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, the most important question is to clarify whether and how PM 2.5 causally contributes to these mental disorders and which components are the most dangerous for crucial mitigation in a particular place
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Real-time emulation of future global warming reveals realistic impacts on the phenological response and quality deterioration in rice Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Hironori Itoh, Hiroto Yamashita, Kaede C. Wada, Jun-ichi Yonemaru
Decreased production of crops due to climate change has been predicted scientifically. While climate-resilient crops are necessary to ensure food security and support sustainable agriculture, predicting crop growth under future global warming is challenging. Therefore, we aimed to assess the impact of realistic global warming conditions on rice cultivation. We developed a crop evaluation platform,
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Long-term declines in chlorophyll a and variable phenology revealed by a 60-year estuarine plankton time series Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Patricia S. Thibodeau, Gavino Puggioni, Jacob Strock, David G. Borkman, Tatiana A. Rynearson
Long-term ecological time series provide a unique perspective on the emergent properties of ecosystems. In aquatic systems, phytoplankton form the base of the food web and their biomass, measured as the concentration of the photosynthetic pigment chlorophyll a (chl a ), is an indicator of ecosystem quality. We analyzed temporal trends in chl a from the Long-Term Plankton Time Series in Narragansett
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Extreme shifts in pyrite sulfur isotope compositions reveal the path to bonanza gold Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Duncan F. McLeish, Anthony E. Williams-Jones, James R. Clark, Richard A. Stern
Pyrite is the most common sulfide mineral in hydrothermal ore-forming systems. The ubiquity and abundance of pyrite, combined with its ability to record and preserve a history of fluid evolution in crustal environments, make it an ideal mineral for studying the genesis of hydrothermal ore deposits, including those that host critical metals. However, with the exception of boiling, few studies have been
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Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73 Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Dan Li, Catherine Yen Li Kok, Chao Wang, Debleena Ray, Susanne Osterburg, Volker Dötsch, Sujoy Ghosh, Kanaga Sabapathy
The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell death and also supports tumorigenesis, although the mechanistic basis for the dichotomous functions is poorly understood. We report here the identification of an alternate transactivation domain (TAD) located at the extreme carboxyl (C) terminus of TAp73β, a commonly expressed p73 isoform. Mutational disruption
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Solvent constraints for biopolymer folding and evolution in extraterrestrial environments Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Ignacio E. Sánchez, Ezequiel A. Galpern, Diego U. Ferreiro
We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to the chemical composition of biopolymers and crucially depend on the solvent in which they are embedded. We show that molecular information theory and energy landscape theory allow us to explore the limits that solvents impose
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Clocking out and letting go to unleash green biotech applications in a photosynthetic host Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Yao Xu, Maria Luísa Jabbur, Tetsuya Mori, Jamey D. Young, Carl Hirschie Johnson
Cyanobacteria are photosynthetic bacteria whose gene expression patterns are globally regulated by their circadian (daily) clocks. Due to their ability to use sunlight as their energy source, they are also attractive hosts for “green” production of pharmaceuticals, renewable fuels, and chemicals. However, despite the application of traditional genetic tools such as the identification of strong promoters
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Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-13 Harry R. King, Mark Bycroft, Thanh-Binh Nguyen, Geoff Kelly, Alexander A. Vinogradov, Pamela J. E. Rowling, Katherine Stott, David B. Ascher, Hiroaki Suga, Laura S. Itzhaki, Katerina Artavanis-Tsakonas
The ubiquitin–proteasome system is essential to all eukaryotes and has been shown to be critical to parasite survival as well, including Plasmodium falciparum , the causative agent of the deadliest form of malarial disease. Despite the central role of the ubiquitin–proteasome pathway to parasite viability across its entire life-cycle, specific inhibitors targeting the individual enzymes mediating ubiquitin
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Mechanics limits ecological diversity and promotes heterogeneity in confined bacterial communities Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-10 Tianyi Ma, Jeremy Rothschild, Faisal Halabeya, Anton Zilman, Joshua N. Milstein
Multispecies bacterial populations often inhabit confined and densely packed environments where spatial competition determines the ecological diversity of the community. However, the role of mechanical interactions in shaping the ecology is still poorly understood. Here, we study a model system consisting of two populations of nonmotile Escherichia coli bacteria competing within open, monolayer microchannels
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General reversal of N-decomposition relationship during long-term decomposition in boreal and temperate forests Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-10 Tao Sun, Lili Dong, Yunyu Zhang, Stephan Hättenschwiler, William H. Schlesinger, Jiaojun Zhu, Björn Berg, E. Carol Adair, Yunting Fang, Sarah E. Hobbie
Decomposition of dead organic matter is fundamental to carbon (C) and nutrient cycling in terrestrial ecosystems, influencing C fluxes from the biosphere to the atmosphere. Theory predicts and evidence strongly supports that the availability of nitrogen (N) limits litter decomposition. Positive relationships between substrate N concentrations and decomposition have been embedded into ecosystem models
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Lethal cyanobacteria are creeping into rivers—no one knows exactly why Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Amy McDermott
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A journey to your self: The vague definition of immune self and its practical implications Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Balázs Koncz, Gergő Mihály Balogh, Máté Manczinger
The identification of immunogenic peptides has become essential in an increasing number of fields in immunology, ranging from tumor immunotherapy to vaccine development. The nature of the adaptive immune response is shaped by the similarity between foreign and self-protein sequences, a concept extensively applied in numerous studies. Can we precisely define the degree of similarity to self? Furthermore
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Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Taylor N. SzyszkaMichael P. AndreasFelicia LieLohra M. MillerLachlan S. R. AdamsonFarzad FatehiReidun TwarockBenjamin E. DraperMartin F. JarroldTobias W. GiessenYu Heng LauaSchool of Chemistry, The University of Sydney, Camperdown, NSW 2006, AustraliabThe University of Sydney Nano Institute, The University of Sydney, Camperdown, NSW 2006, AustraliacDepartment of Biological Chemistry, University of
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Modeling homologous chromosome recognition via nonspecific interactions Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Wallace F. MarshallJennifer C. FungaDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158bDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94158cCenter for Reproductive Sciences, University of California, San Francisco, CA 94158
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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The Andes–Amazon–Atlantic pathway: A foundational hydroclimate system for social–ecological system sustainability Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Claire F. Beveridge, Jhan-Carlo Espinoza, Simone Athayde, Sandra Bibiana Correa, Thiago B. A. Couto, Sebastian A. Heilpern, Clinton N. Jenkins, Natalia C. Piland, Renata Utsunomiya, Sly Wongchuig, Elizabeth P. Anderson
The Amazon River Basin’s extraordinary social–ecological system is sustained by various water phases, fluxes, and stores that are interconnected across the tropical Andes mountains, Amazon lowlands, and Atlantic Ocean. This “Andes–Amazon–Atlantic” (AAA) pathway is a complex hydroclimatic system linked by the regional water cycle through atmospheric circulation and continental hydrology. Here, we aim
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Copper(II) coordination to the intrinsically disordered region of SARS-CoV-2 Nsp1 Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Maryann MoralesMoon Young YangWilliam A. GoddardHarry B. GrayJay R. WinkleraBeckman Institute, California Institute of Technology, Pasadena, CA 91125
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Can Generative AI improve social science? Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-09 Christopher A. Bail
Generative AI that can produce realistic text, images, and other human-like outputs is currently transforming many different industries. Yet it is not yet known how such tools might influence social science research. I argue Generative AI has the potential to improve survey research, online experiments, automated content analyses, agent-based models, and other techniques commonly used to study human
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07
Proceedings of the National Academy of Sciences, Volume 121, Issue 19, May 2024.
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Dynamics of membrane tubulation coupled with fission by a two-component module Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-08 Soumya BhattacharyyaThomas J. PucadyilaIndian Institute of Science Education and Research, Pashan, Pune 411008, Maharashtra, India
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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DNA lesion bypass and the stochastic dynamics of transcription-coupled repair Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-08 Michael D. NicholsonCraig J. AndersonDuncan T. OdomSarah J. AitkenMartin S. TayloraCancer Research United Kingdom Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United KingdombMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United KingdomcDivision of Regulatory Genomics and Cancer
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A mechanistic model of gossip, reputations, and cooperation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-08 Mari KawakatsuTaylor A. KessingerJoshua B. PlotkinaDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104bCenter for Mathematical Biology, University of Pennsylvania, Philadelphia, PA 19104
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A dopamine mechanism for reward maximization Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-08 Wolfram SchultzaDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Unveiling the role of proton concentration in dinuclear metal complexes for boosting photocatalytic CO2 reduction Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Hui-Feng WangHong-Juan WangDi-Chang ZhongTong-Bu LuaMinistry of Education (MOE) International Joint Laboratory of Materials Microstructure, Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Suzanne MéliqueAurélie VadelNelly RouquiéCui YangCyrielle BoriesColine CotineauAbdelhadi SaoudiNicolas FazilleauRenaud LesourneaToulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291, CNRS UMR5051, University Toulouse III, Toulouse 31024, France
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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DNA polymerase delta governs parental histone transfer to DNA replication lagging strand Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Congcong TianQin ZhangJing JiaJiaqi ZhouZiwei ZhangSrinivasu KarriJiuhang JiangQuinn DickinsonYuan YaoXiaorong TangYuxin HuangTing GuoZiwei HeZheng LiuYuan GaoXinran YangYuchun WuKui Ming ChanDaoqin ZhangJunhong HanChuanhe YuHaiyun GanaShenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Key Laboratory of Quantitative Synthetic Biology, Shenzhen
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A TME-enlightened protein-binding photodynamic nanoinhibitor for highly effective oncology treatment Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Zepeng CuiBaoxuan HuangJiahao ZhengJia TianWeian ZhangaShanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of ChinabSchool of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Viraj DoddihalFrederick G. MannEric J. RossMary C. McKinneyCarlos Guerrero-HernándezCarolyn E. BrewsterSean A. McKinneyAlejandro Sánchez AlvaradoaStowers Institute for Medical Research, Kansas City, MO 64110
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Xiaoyi G. LiangKendy HoangBrandon L. MeyerinkPratiksha KcKitt ParaisoLi WangIan R. JonesYue ZhangSol KatzmanThomas S. FinnJeremiah TsyporinFangyuan QuZhaoxu ChenAxel ViselArnold KriegsteinYin ShenLouis-Jan PilazBin ChenaDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064bDivision of Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Tumor–neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Weiqiang JingGanyu WangZhiwei CuiXinyuan LiShuyan ZengXin JiangWushan LiBo HanNianzeng XingYunxue ZhaoShouzhen ChenBenkang ShiaDepartment of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, ChinabDepartment of Pediatric Surgery, Qilu Hospital Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, ChinacDepartment
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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A distinct, high-affinity, alkaline phosphatase facilitates occupation of P-depleted environments by marine picocyanobacteria Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-07 Alberto Torcello-RequenaAndrew R. J. MurphyIan D. E. A. LidburyFrances D. PittRichard StarkAndrew D. MillardRichard J. PuxtyYin ChenDavid J. ScanlanaSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United KingdombMolecular Microbiology: Biochemistry to Disease, School of Biosciences, University of Sheffield, Sheffield S10 2TN, United KingdomcCentre for Phage Research, Department of
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Correction for Fransen et al., High-throughput experimentation for discovery of biodegradable polyesters Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-06
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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The ‘hot’ chiral optical effects Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-06 Yang ZhaoaDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801bNick Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801cBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801dDepartment of Bioengineering, University of Illinois Urbana-Champaign
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Stopover strategies drive potential adaptability under changing environments Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-06 Kyle G. HortonYuting DengaDepartment of Fish, Wildlife, and Conservation Biology, Colorado State University, Fort Collins, CO 80523
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.
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Liquid–liquid transition and ice crystallization in a machine-learned coarse-grained water model Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-06 Debdas DhabalRajat KumarValeria MolineroaDepartment of Chemistry, The University of Utah, Salt Lake City, UT 84112-0850
Proceedings of the National Academy of Sciences, Volume 121, Issue 20, May 2024.