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Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Angela M. Richardson, Greta Sokoloff, Mark S. Blumberg
Animals must distinguish the sensory consequences of self-generated movements (reafference) from those of other-generated movements (exafference). Only self-generated movements entail the production of motor copies (i.e., corollary discharges), which are compared with reafference in the cerebellum to compute predictive or internal models of movement. Internal models emerge gradually over the first
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Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Dylan Curtin, Eleanor M. Taylor, Mark A. Bellgrove, Trevor T-J. Chong, James P. Coxon
Exercise is known to benefit motor skill learning in health and neurological disease. Evidence from brain stimulation, genotyping, and Parkinson's disease studies converge to suggest that the dopamine D2 receptor, and shifts in the cortical excitation and inhibition (E:I) balance, are prime candidates for the drivers of exercise-enhanced motor learning. However, causal evidence using experimental pharmacological
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Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Jing Zhou, Alfie Wearn, Julia Huck, Colleen Hughes, Giulia Baracchini, Jennifer Tremblay-Mercier, Judes Poirier, Sylvia Villeneuve, Christine Lucas Tardif, M. Mallar Chakravarty, Ana M. Daugherty, Claudine J. Gauthier, Gary R. Turner, R. Nathan Spreng, PREVENT-AD Research Group
Elevated iron deposition in the brain has been observed in older adult humans and persons with Alzheimer's disease (AD), and has been associated with lower cognitive performance. We investigated the impact of iron deposition, and its topographical distribution across hippocampal subfields and segments (anterior, posterior) measured along its longitudinal axis, on episodic memory in a sample of cognitively
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Visual Corticotectal Neurons in Awake Rabbits: Receptive Fields and Driving Monosynaptic Thalamocortical Inputs J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Chuyi Su, Rosangela F. Mendes-Platt, Jose-Manuel Alonso, Harvey A. Swadlow, Yulia Bereshpolova
The superior colliculus receives powerful synaptic inputs from corticotectal neurons in the visual cortex. The function of these corticotectal neurons remains largely unknown due to a limited understanding of their response properties and connectivity. Here, we use antidromic methods to identify corticotectal neurons in awake male and female rabbits, and measure their axonal conduction times, thalamic
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Double Dissociation of Spontaneous Alpha-Band Activity and Pupil-Linked Arousal on Additive and Multiplicative Perceptual Gain J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 April Pilipenko, Jason Samaha
Perception is a probabilistic process dependent on external stimulus properties and one's internal state. However, which internal states influence perception and via what mechanisms remain debated. We studied how spontaneous alpha-band activity (8–13 Hz) and pupil fluctuations impact visual detection and confidence across stimulus contrast levels (i.e., the contrast response function, CRF). In human
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Deletion of the Clock Gene Bmal2 Leads to Alterations in Hypothalamic Clocks, Circadian Regulation of Feeding, and Energy Balance J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Rosana Dantas-Ferreira, Dominique Ciocca, Patrick Vuillez, Stéphanie Dumont, Christian Boitard, Ute C. Rogner, Etienne Challet
BMAL2 (ARNTL2) is a paralog of BMAL1 that can form heterodimers with the other circadian factors CLOCK and NPAS2 to activate transcription of clock and clock-controlled genes. To assess a possible role of Bmal2 in the circadian regulation of metabolism, we investigated daily variations of energy metabolism, feeding behavior, and locomotor behavior, as well as ability to anticipate restricted food access
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TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Amelia M. Burch, Joshua D. Garcia, Heather O’Leary, Ami Haas, James E. Orfila, Erika Tiemeier, Nicholas Chalmers, Katharine R. Smith, Nidia Quillinan, Paco S. Herson
Excitotoxicity and the concurrent loss of inhibition are well-defined mechanisms driving acute elevation in excitatory/inhibitory (E/I) balance and neuronal cell death following an ischemic insult to the brain. Despite the high prevalence of long-term disability in survivors of global cerebral ischemia (GCI) as a consequence of cardiac arrest, it remains unclear whether E/I imbalance persists beyond
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Basic Properties of Coordinated Neuronal Ensembles in the Auditory Thalamus J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Congcong Hu, Andrea R. Hasenstaub, Christoph E. Schreiner
Coordinated neuronal activity has been identified to play an important role in information processing and transmission in the brain. However, current research predominantly focuses on understanding the properties and functions of neuronal coordination in hippocampal and cortical areas, leaving subcortical regions relatively unexplored. In this study, we use single-unit recordings in female Sprague
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Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Hannah M. Weman, Mikaela M. Ceder, Aikeremu Ahemaiti, Kajsa A. Magnusson, Katharina Henriksson, Linn Andréasson, Malin C. Lagerström
Glycinergic neurons regulate nociceptive and pruriceptive signaling in the spinal cord, but the identity and role of the glycine-regulated neurons are not fully known. Herein, we have characterized spinal glycine receptor alpha 3 (Glra3) subunit-expressing neurons in Glra3-Cre female and male mice. Glra3-Cre(+) neurons express Glra3, are located mainly in laminae III–VI, and respond to glycine. Chemogenetic
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The Intellectual Disability Risk Gene Kdm5b Regulates Long-Term Memory Consolidation in the Hippocampus J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Leticia Pérez-Sisqués, Shail U. Bhatt, Rugile Matuleviciute, Talia E. Gileadi, Eniko Kramar, Andrew Graham, Franklin G. Garcia, Ashley Keiser, Dina P. Matheos, James A. Cain, Alan M. Pittman, Laura C. Andreae, Cathy Fernandes, Marcelo A. Wood, K. Peter Giese, M. Albert Basson
The histone lysine demethylase KDM5B is implicated in recessive intellectual disability disorders, and heterozygous, protein-truncating variants in KDM5B are associated with reduced cognitive function in the population. The KDM5 family of lysine demethylases has developmental and homeostatic functions in the brain, some of which appear to be independent of lysine demethylase activity. To determine
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A Neural Decision Signal during Internal Sampling from Working Memory in Humans J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Freek van Ede, Anna C. Nobre
How humans transform sensory information into decisions that steer purposeful behavior is a central question in psychology and neuroscience that is traditionally investigated during the sampling of external environmental signals. The decision-making framework of gradual information sampling toward a decision has also been proposed to apply when sampling internal sensory evidence from working memory
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Balancing the Senses: Electrophysiological Responses Reveal the Interplay between Somatosensory and Visual Processing During Body-Related Multisensory Conflict J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Alice Rossi Sebastiano, Karol Poles, Stefano Gualtiero, Marcella Romeo, Mattia Galigani, Valentina Bruno, Carlotta Fossataro, Francesca Garbarini
In the study of bodily awareness, the predictive coding theory has revealed that our brain continuously modulates sensory experiences to integrate them into a unitary body representation. Indeed, during multisensory illusions (e.g., the rubber hand illusion, RHI), the synchronous stroking of the participant’s concealed hand and a fake visible one creates a visuotactile conflict, generating a prediction
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Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Gerda E. Breitwieser, Andrea Cippitelli, Yingcai Wang, Oliver Pelletier, Ridge Dershem, Jianning Wei, Lawrence Toll, Bianca Fakhoury, Gloria Brunori, Raghu Metpally, David J. Carey, the Regeneron Genetics Center, Janet Robishaw
GPR37L1 is an orphan receptor that couples through heterotrimeric G-proteins to regulate physiological functions. Since its role in humans is not fully defined, we used an unbiased computational approach to assess the clinical significance of rare G-protein-coupled receptor 37-like 1 (GPR37L1) genetic variants found among 51,289 whole-exome sequences from the DiscovEHR cohort. Rare GPR37L1 coding variants
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Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity J. Neurosci. (IF 5.3) Pub Date : 2024-05-08 Siyu Chen, Rachel M. Rahn, Annie R. Bice, Seana H. Bice, Jonah A. Padawer-Curry, Keith B. Hengen, Joseph D. Dougherty, Joseph P. Culver
A classic example of experience-dependent plasticity is ocular dominance (OD) shift, in which the responsiveness of neurons in the visual cortex is profoundly altered following monocular deprivation (MD). It has been postulated that OD shifts also modify global neural networks, but such effects have never been demonstrated. Here, we use wide-field fluorescence optical imaging (WFOI) to characterize
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Dissociable Contributions of the Medial Parietal Cortex to Recognition Memory J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Seth R. Koslov, Joseph W. Kable, Brett L. Foster
Human neuroimaging studies of episodic memory retrieval routinely observe the engagement of specific cortical regions beyond the medial temporal lobe. Of these, medial parietal cortex (MPC) is of particular interest given its distinct functional characteristics during different retrieval tasks. Specifically, while recognition and autobiographical recall tasks are both used to probe episodic retrieval
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KSR1 Knockout Mouse Model Demonstrates MAPK Pathways Key Role in Cisplatin- and Noise-induced Hearing Loss J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Matthew A. Ingersoll, Richard D. Lutze, Regina G. Kelmann, Daniel F. Kresock, Jordan D. Marsh, Rene V. Quevedo, Jian Zuo, Tal Teitz
Hearing loss is a major disability in everyday life and therapeutic interventions to protect hearing would benefit a large portion of the world population. Here we found that mice devoid of the protein kinase suppressor of RAS 1 (KSR1) in their tissues (germline KO mice) exhibit resistance to both cisplatin- and noise-induced permanent hearing loss compared with their wild-type KSR1 littermates. KSR1
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Calibrating Bayesian Decoders of Neural Spiking Activity J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Ganchao Wei (魏赣超), Zeinab Tajik Mansouri (زینب تاجیک منصوری), Xiaojing Wang (王晓婧), Ian H. Stevenson
Accurately decoding external variables from observations of neural activity is a major challenge in systems neuroscience. Bayesian decoders, which provide probabilistic estimates, are some of the most widely used. Here we show how, in many common settings, the probabilistic predictions made by traditional Bayesian decoders are overconfident. That is, the estimates for the decoded stimulus or movement
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Pupillary Responses Reflect Dynamic Changes in Multiple Cognitive Factors During Associative Learning in Primates J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Yange Zhang (张艳歌), Tian Wang (王天), Weifeng Dai (戴伟枫), Yang Li (李洋), Yi Yang (杨祎), Yujie Wu (武宇洁), Jiancao Huang (黄见操), Tingting Zhou (周婷婷), Dajun Xing (邢大军)
Associative learning involves complex interactions of multiple cognitive factors. While adult subjects can articulate these factors verbally, for model animals such as macaques, we rely on behavioral outputs. In our study, we used pupillary responses as an alternative measure to capture these underlying cognitive changes. We recorded the dynamic changes in the pupils of three male macaques when they
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An Enduring Role for Hippocampal Pattern Completion in Addition to an Emergent Nonhippocampal Contribution to Holistic Episodic Retrieval after a 24 h Delay J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Bárður H. Joensen, Jennifer E. Ashton, Sam C. Berens, M. Gareth Gaskell, Aidan J. Horner
Episodic memory retrieval is associated with the holistic neocortical reinstatement of all event information, an effect driven by hippocampal pattern completion. However, whether holistic reinstatement occurs, and whether hippocampal pattern completion continues to drive reinstatement, after a period of consolidation is unclear. Theories of systems consolidation predict either a time-variant or time-invariant
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Cone-Opponent Ganglion Cells in the Primate Fovea Tuned to Noncardinal Color Directions J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Tyler Godat, Kendall Kohout, Keith Parkins, Qiang Yang, Juliette E. McGregor, William H. Merigan, David R. Williams, Sara S. Patterson
A long-standing question in vision science is how the three cone photoreceptor types—long (L), medium (M), and short (S) wavelength sensitive—combine to generate our perception of color. Hue perception can be described along two opponent axes: red–green and blue–yellow. Psychophysical measurements of color appearance indicate that the cone inputs to the red–green and blue–yellow opponent axes are M
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Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Maëlle Bertho, Vanessa Caldeira, Li-Ju Hsu, Peter Löw, Lotta Borgius, Ole Kiehn
Locomotion allows us to move and interact with our surroundings. Spinal networks that control locomotion produce rhythm and left–right and flexor–extensor coordination. Several glutamatergic populations, Shox2 non-V2a, Hb9-derived interneurons, and, recently, spinocerebellar neurons have been proposed to be involved in the mouse rhythm generating networks. These cells make up only a smaller fraction
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Multimodal Interrogation of Ventral Pallidum Projections Reveals Projection-Specific Signatures and Effects on Cocaine Reward J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Nimrod Bernat, Rianne R. Campbell, Hyungwoo Nam, Mahashweta Basu, Tal Odesser, Gal Elyasaf, Michel Engeln, Ramesh Chandra, Shana Golden, Seth Ament, Mary Kay Lobo, Yonatan M. Kupchik
The ventral pallidum (VP) is a central hub in the reward circuitry with diverse projections that have different behavioral roles attributed mostly to the connectivity with the downstream target. However, different VP projections may represent, as in the striatum, separate neuronal populations that differ in more than just connectivity. In this study, we performed in mice of both sexes a multimodal
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Differential Expression Analysis Identifies Candidate Synaptogenic Molecules for Wiring Direction-Selective Circuits in the Retina J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Joshua M. Tworig, Ryan D. Morrie, Karina Bistrong, Rachana D. Somaiya, Shaw Hsu, Jocelyn Liang, Karen G. Cornejo, Marla B. Feller
An organizational feature of neural circuits is the specificity of synaptic connections. A striking example is the direction-selective (DS) circuit of the retina. There are multiple subtypes of DS retinal ganglion cells (DSGCs) that prefer motion along one of four preferred directions. This computation is mediated by selective wiring of a single inhibitory interneuron, the starburst amacrine cell (SAC)
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Tmod2 Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Arojit Mitra, Sean P. Deats, Price E. Dickson, Jiuhe Zhu, Justin Gardin, Brian J. Nieman, R. Mark Henkelman, Nien-Pei Tsai, Elissa J. Chesler, Zhong-Wei Zhang, Vivek Kumar
Drugs of abuse induce neuroadaptations, including synaptic plasticity, that are critical for transition to addiction, and genes and pathways that regulate these neuroadaptations are potential therapeutic targets. Tropomodulin 2 (Tmod2) is an actin-regulating gene that plays an important role in synapse maturation and dendritic arborization and has been implicated in substance abuse and intellectual
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Frequency of Spontaneous Neurotransmission at Individual Boutons Corresponds to the Size of the Readily Releasable Pool of Vesicles J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Amelia J. Ralowicz, Sasipha Hokeness, Michael B. Hoppa
Synapses maintain two forms of neurotransmitter release to support communication in the brain. First, evoked neurotransmitter release is triggered by the invasion of an action potential (AP) across en passant boutons that form along axons. The probability of evoked release (Pr) varies substantially across boutons, even within a single axon. Such heterogeneity is the result of differences in the probability
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Intrinsic and Synaptic Contributions to Repetitive Spiking in Dentate Granule Cells J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Wen-Chi Shu, Meyer B. Jackson
Repetitive firing of granule cells (GCs) in the dentate gyrus (DG) facilitates synaptic transmission to the CA3 region. This facilitation can gate and amplify the flow of information through the hippocampus. High-frequency bursts in the DG are linked to behavior and plasticity, but GCs do not readily burst. Under normal conditions, a single shock to the perforant path in a hippocampal slice typically
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Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer's Disease J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Khazar Ahmadi, Joana B. Pereira, Danielle van Westen, Ofer Pasternak, Fan Zhang, Markus Nilsson, Erik Stomrud, Nicola Spotorno, Oskar Hansson
Several studies have shown white matter (WM) abnormalities in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). Nonetheless, robust characterization of WM changes has been challenging due to the methodological limitations of DTI. We applied fixel-based analyses (FBA) to examine microscopic differences in fiber density (FD) and macroscopic changes in fiber cross-section (FC) in early stages
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Pre-acquired Functional Connectivity Predicts Choice Inconsistency J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Asaf Madar, Vered Kurtz-David, Adam Hakim, Dino J. Levy, Ido Tavor
Economic choice theories usually assume that humans maximize utility in their choices. However, studies have shown that humans make inconsistent choices, leading to suboptimal behavior, even without context-dependent manipulations. Previous studies showed that activation in value and motor networks are associated with inconsistent choices at the moment of choice. Here, we investigated if the neural
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Tob Regulates the Timing of Sleep Onset at Night in Drosophila J. Neurosci. (IF 5.3) Pub Date : 2024-05-01 Emily Han, Sang Soo Lee, Kristen H. Park, Ian D. Blum, Qiang Liu, Anuradha Mehta, Isabelle Palmer, Habon Issa, Alice Han, Matt P. Brown, Victor M. Sanchez-Franco, Miguel Velasco, Masashi Tabuchi, Mark N. Wu
Sleep is regulated by homeostatic sleep drive and the circadian clock. While tremendous progress has been made in elucidating the molecular components of the core circadian oscillator, the output mechanisms by which this robust oscillator generates rhythmic sleep behavior remain poorly understood. At the cellular level, growing evidence suggests that subcircuits in the master circadian pacemaker suprachiasmatic
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Spatiotemporal Dynamics of Successive Activations across the Human Brain during Simple Arithmetic Processing J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Pedro Pinheiro-Chagas, Clara Sava-Segal, Serdar Akkol, Amy Daitch, Josef Parvizi
Previous neuroimaging studies have offered unique insights about the spatial organization of activations and deactivations across the brain; however, these were not powered to explore the exact timing of events at the subsecond scale combined with a precise anatomical source of information at the level of individual brains. As a result, we know little about the order of engagement across different
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Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Sophie R. Liebergall, Ethan M. Goldberg
Dravet syndrome (DS) is a neurodevelopmental disorder characterized by epilepsy, developmental delay/intellectual disability, and features of autism spectrum disorder, caused by heterozygous loss-of-function variants in SCN1A encoding the voltage-gated sodium channel α subunit Nav1.1. The dominant model of DS pathogenesis is the "interneuron hypothesis," whereby GABAergic interneurons (INs) express
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Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Tomas G. Aquino, Hristos Courellis, Adam N. Mamelak, Ueli Rutishauser, John P. O′Doherty
Pavlovian conditioning is thought to involve the formation of learned associations between stimuli and values, and between stimuli and specific features of outcomes. Here, we leveraged human single neuron recordings in ventromedial prefrontal, dorsomedial frontal, hippocampus, and amygdala while patients of both sexes performed an appetitive Pavlovian conditioning task probing both stimulus–value and
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Integration of Prior Expectations and Suppression of Prediction Errors During Expectancy-Induced Pain Modulation: The Influence of Anxiety and Pleasantness J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Hsin-Yun Tsai, Kulvara Lapanan, Yi-Hsuan Lin, Cheng-Wei Huang, Wen-Wei Lin, Min-Min Lin, Zheng-Liang Lu, Feng-Sheng Lin, Ming-Tsung Tseng
Pain perception arises from the integration of prior expectations with sensory information. Although recent work has demonstrated that treatment expectancy effects (e.g., placebo hypoalgesia) can be explained by a Bayesian integration framework incorporating the precision level of expectations and sensory inputs, the key factor modulating this integration in stimulus expectancy-induced pain modulation
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Acetylcholine Engages Distinct Amygdala Microcircuits to Gate Internal Theta Rhythm J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Joshua X. Bratsch-Prince, James W. Warren, Grace C. Jones, Alexander J. McDonald, David D. Mott
Acetylcholine (ACh) is released from basal forebrain cholinergic neurons in response to salient stimuli and engages brain states supporting attention and memory. These high ACh states are associated with theta oscillations, which synchronize neuronal ensembles. Theta oscillations in the basolateral amygdala (BLA) in both humans and rodents have been shown to underlie emotional memory, yet their mechanism
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Re-examining the Mysterious Role of the Cerebellum in Pain J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Crystal N. Li, Kevin A. Keay, Luke A. Henderson, Richelle Mychasiuk
Pain is considered a multidimensional experience that embodies not merely sensation, but also emotion and perception. As is appropriate for this complexity, pain is represented and processed by an extensive matrix of cortical and subcortical structures. Of these structures, the cerebellum is gaining increasing attention. Although association between the cerebellum and both acute and chronic pain have
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Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Amy S. Kohtz, Joshua Zhao, Gary Aston-Jones
The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by blocking 5-HT signaling in dorsal hippocampal cornu ammonis 1 (CA1) in both male and female rats. We hypothesized that the experience of ED1 can substantially influence later relapse behavior and that dorsal
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Hypothalamic Paraventricular Stimulation Inhibits Nociceptive Wide Dynamic Range Trigeminocervical Complex Cells via Oxytocinergic Transmission J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Miguel Condés-Lara, Guadalupe Martínez-Lorenzana, Antonio Espinosa de los Monteros-Zúñiga, Gustavo López-Córdoba, Aketzalli Córdova-Quiroga, Shakty A. Flores-Bojórquez, Abimael González-Hernández
Oxytocinergic transmission blocks nociception at the peripheral, spinal, and supraspinal levels through the oxytocin receptor (OTR). Indeed, a neuronal pathway from the hypothalamic paraventricular nucleus (PVN) to the spinal cord and trigeminal nucleus caudalis (Sp5c) has been described. Hence, although the trigeminocervical complex (TCC), an anatomical area spanning the Sp5c, C1, and C2 regions,
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Coupling of Sharp Wave Events between Zebrafish Hippocampal and Amygdala Homologs J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Ismary Blanco, Adam Caccavano, Jian-Young Wu, Stefano Vicini, Eric Glasgow, Katherine Conant
The mammalian hippocampus exhibits spontaneous sharp wave events (1–30 Hz) with an often-present superimposed fast ripple oscillation (120–220 Hz) to form a sharp wave ripple (SWR) complex. During slow-wave sleep or quiet restfulness, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during learned or imagined experiences. Additional cortical/subcortical areas
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The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Stephanie Schrempft, Olga Trofimova, Morgane Künzi, Cristina Ramponi, Antoine Lutti, Ferath Kherif, Adeliya Latypova, Peter Vollenweider, Pedro Marques-Vidal, Martin Preisig, Matthias Kliegel, Silvia Stringhini, Bogdan Draganski
Despite major advances, our understanding of the neurobiology of life course socioeconomic conditions is still scarce. This study aimed to provide insight into the pathways linking socioeconomic exposures—household income, last known occupational position, and life course socioeconomic trajectories—with brain microstructure and cognitive performance in middle to late adulthood. We assessed socioeconomic
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PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Bin Wu, Laura Post, Zhanmin Lin, Martijn Schonewille
Throughout life, the cerebellum plays a central role in the coordination and optimization of movements, using cellular plasticity to adapt a range of behaviors. Whether these plasticity processes establish a fixed setpoint during development, or continuously adjust behaviors throughout life, is currently unclear. Here, by spatiotemporally manipulating the activity of protein phosphatase 2B (PP2B),
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Value Estimation versus Effort Mobilization: A General Dissociation between Ventromedial and Dorsomedial Prefrontal Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Nicolas Clairis, Mathias Pessiglione
Deciding on a course of action requires both an accurate estimation of option values and the right amount of effort invested in deliberation to reach sufficient confidence in the final choice. In a previous study, we have provided evidence, across a series of judgment and choice tasks, for a dissociation between the ventromedial prefrontal cortex (vmPFC), which would represent option values, and the
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Neuronal Modeling of Cross-Sensory Visual Evoked Magnetoencephalography Responses in the Auditory Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Kaisu Lankinen, Jyrki Ahveninen, Mainak Jas, Tommi Raij, Seppo P. Ahlfors
Previous studies have demonstrated that auditory cortex activity can be influenced by cross-sensory visual inputs. Intracortical laminar recordings in nonhuman primates have suggested a feedforward (FF) type profile for auditory evoked but feedback (FB) type for visual evoked activity in the auditory cortex. To test whether cross-sensory visual evoked activity in the auditory cortex is associated with
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PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Shannon N. Leahy, Dominic J. Vita, Kendal Broadie
Cytoplasmic protein tyrosine phosphatase nonreceptor type 11 (PTPN11) and Drosophila homolog Corkscrew (Csw) regulate the mitogen-activated protein kinase (MAPK) pathway via a conserved autoinhibitory mechanism. Disease-causing loss-of-function (LoF) and gain-of-function (GoF) mutations both disrupt this autoinhibition to potentiate MAPK signaling. At the Drosophila neuromuscular junction glutamatergic
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A Unifying Model for Discordant and Concordant Results in Human Neuroimaging Studies of Facial Viewpoint Selectivity J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Cambria Revsine, Javier Gonzalez-Castillo, Elisha P. Merriam, Peter A. Bandettini, Fernando M. Ramírez
Recognizing faces regardless of their viewpoint is critical for social interactions. Traditional theories hold that view-selective early visual representations gradually become tolerant to viewpoint changes along the ventral visual hierarchy. Newer theories, based on single-neuron monkey electrophysiological recordings, suggest a three-stage architecture including an intermediate face-selective patch
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Encoding of Visual Objects in the Human Medial Temporal Lobe J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yue Wang, Runnan Cao, Shuo Wang
The human medial temporal lobe (MTL) plays a crucial role in recognizing visual objects, a key cognitive function that relies on the formation of semantic representations. Nonetheless, it remains unknown how visual information of general objects is translated into semantic representations in the MTL. Furthermore, the debate about whether the human MTL is involved in perception has endured for a long
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Neuronal Ensembles in the Amygdala Allow Social Information to Motivate Later Decisions J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Henry W. Kietzman, Gracy Trinoskey-Rice, Esther H. Seo, Jidong Guo, Shannon L. Gourley
Social experiences carry tremendous weight in our decision-making, even when social partners are not present. To determine mechanisms, we trained female mice to respond for two food reinforcers. Then, one food was paired with a novel conspecific. Mice later favored the conspecific-associated food, even in the absence of the conspecific. Chemogenetically silencing projections from the prelimbic subregion
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Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer's Disease Mouse Model J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Qiao Ye, Gocylen Gast, Erik George Wilfley, Hanh Huynh, Chelsea Hays, Todd C. Holmes, Xiangmin Xu
The subiculum (SUB), a hippocampal formation structure, is among the earliest brain regions impacted in Alzheimer's disease (AD). Toward a better understanding of AD circuit-based mechanisms, we mapped synaptic circuit inputs to dorsal SUB using monosynaptic rabies tracing in the 5xFAD mouse model by quantitatively comparing the circuit connectivity of SUB excitatory neurons in age-matched controls
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Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFN{gamma} Exposure J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Changho Chun, Jung Hyun Lee, Mark Bothwell, Paul Nghiem, Alec S. T. Smith, David L. Mack
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder marked by progressive motor neuron degeneration and muscle denervation. A recent transcriptomic study integrating a wide range of human ALS samples revealed that the upregulation of p53, a downstream target of inflammatory stress, is commonly detected in familial and sporadic ALS cases by a mechanism linked to a transactive
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Defining Overlooked Structures Reveals New Associations between the Cortex and Cognition in Aging and Alzheimer's Disease J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Samira A. Maboudian, Ethan H. Willbrand, Joseph P. Kelly, William J. Jagust, Kevin S. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative
Recent work suggests that indentations of the cerebral cortex, or sulci, may be uniquely vulnerable to atrophy in aging and Alzheimer's disease (AD) and that the posteromedial cortex (PMC) is particularly vulnerable to atrophy and pathology accumulation. However, these studies did not consider small, shallow, and variable tertiary sulci that are located in association cortices and are often associated
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Recurrent Neural Circuits Overcome Partial Inactivation by Compensation and Re-learning J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Colin Bredenberg, Cristina Savin, Roozbeh Kiani
Technical advances in artificial manipulation of neural activity have precipitated a surge in studying the causal contribution of brain circuits to cognition and behavior. However, complexities of neural circuits challenge interpretation of experimental results, necessitating new theoretical frameworks for reasoning about causal effects. Here, we take a step in this direction, through the lens of recurrent
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Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Adam M. Tuttle, Lauren N. Miller, Lindsey J. Royer, Hua Wen, Jimmy J. Kelly, Nicholas L. Calistri, Laura M. Heiser, Alex V. Nechiporuk
Peripheral sensory neurons are a critical part of the nervous system that transmit a multitude of sensory stimuli to the central nervous system. During larval and juvenile stages in zebrafish, this function is mediated by Rohon–Beard somatosensory neurons (RBs). RBs are optically accessible and amenable to experimental manipulation, making them a powerful system for mechanistic investigation of sensory
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Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Ji-Jie Pang, Xiaolong Jiang, Samuel M. Wu
Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording techniques which do not allow simultaneously measuring responses of multiple photoreceptors at various locations in the retina. A multiple electrode recording
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Assessing Spontaneous Categorical Processing of Visual Shapes via Frequency-Tagging EEG J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Jaana Van Overwalle, Stephanie Van der Donck, Sander Van de Cruys, Bart Boets, Johan Wagemans
Categorization is an essential cognitive and perceptual process, which happens spontaneously. However, earlier research often neglected the spontaneous nature of this process by mainly adopting explicit tasks in behavioral or neuroimaging paradigms. Here, we use frequency-tagging (FT) during electroencephalography (EEG) in 22 healthy human participants (both male and female) as a direct approach to
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Converging Effects of Chronic Pain and Binge Alcohol Consumption on Anterior Insular Cortex Neurons Projecting to the Dorsolateral Striatum in Male Mice J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yuexi Yin, David L. Haggerty, Shudi Zhou, Brady K. Atwood, Patrick L. Sheets
Chronic pain and alcohol use disorder (AUD) are highly comorbid, and patients with chronic pain are more likely to meet the criteria for AUD. Evidence suggests that both conditions alter similar brain pathways, yet this relationship remains poorly understood. Prior work shows that the anterior insular cortex (AIC) is involved in both chronic pain and AUD. However, circuit-specific changes elicited
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Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Sandra Tolnai, Mariella Weiß, Rainer Beutelmann, Jens P. Bankstahl, Sonny Bovee, Tobias L. Ross, Georg Berding, Georg M. Klump
Pure-tone audiograms often poorly predict elderly humans’ ability to communicate in everyday complex acoustic scenes. Binaural processing is crucial for discriminating sound sources in such complex acoustic scenes. The compromised perception of communication signals presented above hearing threshold has been linked to both peripheral and central age-related changes in the auditory system. Investigating
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Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Iya Prytkova, Yiyuan Liu, Michael Fernando, Isabel Gameiro-Ros, Dina Popova, Chella Kamarajan, Xiaoling Xuei, David B. Chorlian, Howard J. Edenberg, Jay A. Tischfield, Bernice Porjesz, Zhiping P. Pang, Ronald P. Hart, Alison Goate, Paul A. Slesinger
Genome-wide association studies (GWAS) of electroencephalographic endophenotypes for alcohol use disorder (AUD) has identified noncoding polymorphisms within the KCNJ6 gene. KCNJ6 encodes GIRK2, a subunit of a G-protein-coupled inwardly rectifying potassium channel that regulates neuronal excitability. We studied the effect of upregulating KCNJ6 using an isogenic approach with human glutamatergic neurons
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Intracerebral Dynamics of Sleep Arousals: A Combined Scalp-Intracranial EEG Study J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yingqi Laetitia Wang, Tamir Avigdor, Sana Hannan, Chifaou Abdallah, François Dubeau, Laure Peter-Derex, Birgit Frauscher
As an intrinsic component of sleep architecture, sleep arousals represent an intermediate state between sleep and wakefulness and are important for sleep–wake regulation. They are defined in an all-or-none manner, whereas they actually present a wide range of scalp-electroencephalography (EEG) activity patterns. It is poorly understood how these arousals differ in their mechanisms. Stereo-EEG (SEEG)
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Mnemonic But Not Contextual Feedback Signals Defy Dedifferentiation in the Aging Early Visual Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Isabelle Ehrlich, Javier Ortiz-Tudela, Yi You Tan, Lars Muckli, Yee Lee Shing
Perception is an intricate interplay between feedforward visual input and internally generated feedback signals that comprise concurrent contextual and time-distant mnemonic (episodic and semantic) information. Yet, an unresolved question is how the composition of feedback signals changes across the lifespan and to what extent feedback signals undergo age-related dedifferentiation, that is, a decline
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Insula->Amygdala and Insula->Thalamus Pathways Are Involved in Comorbid Chronic Pain and Depression-Like Behavior in Mice J. Neurosci. (IF 5.3) Pub Date : 2024-04-10 Jing Chen, Yuan Gao, Shu-Ting Bao, Ying-Di Wang, Tao Jia, Cui Yin, Cheng Xiao, Chunyi Zhou
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment of either one because they exacerbate each other with unknown mechanisms. As the posterior insular cortex (PIC) integrates multiple somatosensory and emotional information and is implicated in either chronic pain or depression, we hypothesize that the PIC and its projections may contribute to the pathophysiology
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Focal Brain Lesions Causing Acquired Amusia Map to a Common Brain Network J. Neurosci. (IF 5.3) Pub Date : 2024-04-10 Aleksi J. Sihvonen, Michael A. Ferguson, Vicky Chen, Seppo Soinila, Teppo Särkämö, Juho Joutsa
Music is a universal human attribute. The study of amusia, a neurologic music processing deficit, has increasingly elaborated our view on the neural organization of the musical brain. However, lesions causing amusia occur in multiple brain locations and often also cause aphasia, leaving the distinct neural networks for amusia unclear. Here, we utilized lesion network mapping to identify these networks