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Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING Mol. Cell (IF 16.0) Pub Date : 2024-05-14 Tohru Takaki, Rhona Millar, Crispin T. Hiley, Simon J. Boulton
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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins Mol. Cell (IF 16.0) Pub Date : 2024-05-08 Jia Ji, Meng-Ke Cui, Rong Zou, Ming-Zhi Wu, Man-Xi Ge, Jiqiang Li, Zai-Rong Zhang
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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex Mol. Cell (IF 16.0) Pub Date : 2024-05-03 Dimitrios Papadopoulos, Stefanie Anh Ha, Daniel Fleischhauer, Leonie Uhl, Timothy J. Russell, Ivan Mikicic, Katharina Schneider, Annika Brem, Omkar Rajendra Valanju, Giacomo Cossa, Peter Gallant, Christina Schuelein-Voelk, Hans Michael Maric, Petra Beli, Gabriele Büchel, Seychelle M. Vos, Martin Eilers
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The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics Mol. Cell (IF 16.0) Pub Date : 2024-05-03 Sook Wah Yee, Christian B. Macdonald, Darko Mitrovic, Xujia Zhou, Megan L. Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan D. Trinidad, Swati S. More, Linda Kachuri, John S. Witte, Lucie Delemotte, Kathleen M. Giacomini, Willow Coyote-Maestas
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DDX21: The link between m6A and R-loops Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Guillaume Lavergne, Jean-Yves Roignant
In this issue of Molecular Cell, Hao et al.1 demonstrate that the RNA helicase DDX21 recruits the m6A methyltransferase complex to R-loops, ensuring proper transcription termination and genome stability.
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eIF4G as a switch for heat shock mRNA translation Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Yi Liu, Peiguo Yang
The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al.1 demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response.
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Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Ruey-Hwa Chen
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
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Polyphosphate attachment to lysine repeats is a non-covalent protein modification Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Nolan Neville, Kirsten Lehotsky, Kody A. Klupt, Michael Downey, Zongchao Jia
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On the covalent nature of lysine polyphosphorylation Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Cristina Azevedo, Filipy Borghi, Xue Bessie Su, Adolfo Saiardi
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Energy sensor AMPKγ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Rasmus Kjøbsted, Jesper Bratz Birk, Nicolas Oldenburg Eskesen, Jørgen Frank Pind Wojtaszewski
No Abstract
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Response to: Energy sensor AMPKγ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Qi Zhou, Xiaolei Cao, Bin Zhao
No Abstract
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Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Qi Zhou, Bingbing Hao, Xiaolei Cao, Lin Gao, Zhenyue Yu, Yang Zhao, Mingrui Zhu, Guoxuan Zhong, Fangtao Chi, Xiaoming Dai, Jizhong Mao, Yibing Zhu, Ping Rong, Liang Chen, Xueli Bai, Cunqi Ye, Shuai Chen, Tingbo Liang, Li Li, Xin-Hua Feng, Bin Zhao
No Abstract
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Unprocessed genomic uracil as a source of DNA replication stress in cancer cells Mol. Cell (IF 16.0) Pub Date : 2024-04-29 Sneha Saxena, Christopher S. Nabel, Turner W. Seay, Parasvi S. Patel, Ajinkya S. Kawale, Caroline R. Crosby, Helene Tigro, Eugene Oh, Matthew G. Vander Heiden, Aaron N. Hata, Zucai Suo, Lee Zou
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GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies Mol. Cell (IF 16.0) Pub Date : 2024-04-29 Salima Benbarche, Jose Mario Bello Pineda, Laura Baquero Galvis, Jeetayu Biswas, Bo Liu, Eric Wang, Qian Zhang, Simon J. Hogg, Kadeen Lyttle, Ariana Dahi, Alexander M. Lewis, Martina Sarchi, Jahan Rahman, Nina Fox, Yuxi Ai, Sanjoy Mehta, Ralph Garippa, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Robert F. Stanley, Sergei Doulatov, Robert K. Bradley, Omar Abdel-Wahab
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Principles of chromosome organization for meiotic recombination Mol. Cell (IF 16.0) Pub Date : 2024-04-23 Mathilde Biot, Attila Toth, Christine Brun, Leon Guichard, Bernard de Massy, Corinne Grey
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Human DNA polymerase θ does not harbor intrinsic nuclease activity Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Denisse Carvajal-Maldonado, Karl Zahn, Ryan Jensen, Richard D. Wood, Sylvie Doublié
Abstract not available
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Meet the authors: Guy Zoltsman and Rina Rosenzweig Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Guy Zoltsman, Rina Rosenzweig
We talk to first and last authors Guy Zoltsman and Rina Rosenzweig about their paper, “A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53,” how every result may be important in the right context, and the importance to Rina that her lab is an encouraging and collaborative place.
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Entangling and disentangling mitotic chromosomes Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Jonathan Baxter
The DNA topological challenges generated by cellular manipulation of extremely long DNA fibers remain poorly understood. In this issue of Molecular Cell, Hildebrand et al.1 describe how mitotic chromosomes are self entangled and that disentanglement requires TOP2 activity in late mitosis.
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Free ribosomal proteins as culprits for nucleolar stress Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Ina Huppertz
Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.1 find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.
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Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Dylan M. Parker, Gaia R. Bublitz, Roy Parker
In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover
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Sequential requirements for distinct Polθ domains during theta-mediated end joining Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Carel Fijen, Lea Drogalis Beckham, Dante Terino, Yuzhen Li, Dale A. Ramsden, Richard D. Wood, Sylvie Doublié, Eli Rothenberg
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No evidence for ac4C within human mRNA upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Joseph Georgeson, Schraga Schwartz
Cytidine acetylation (ac4C) of RNA is a post-transcriptional modification catalyzed by Nat10. Recently, an approach termed RedaC:T was employed to map ac4C in human mRNA, relying on detection of C>T mutations in WT but not in Nat10-KO cells. RedaC:T suggested widespread ac4C presence. Here, we reanalyze RedaC:T data. We find that mismatch signatures are not reproducible, as C>T mismatches are nearly
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Detection of ac4C in human mRNA is preserved upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Hamid Beiki, David Sturgill, Daniel Arango, Sebastien Relier, Sarah Schiffers, Shalini Oberdoerffer
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). Our results contradicted an earlier report from Schwartz and colleagues utilizing a similar method termed ac4C-seq. Here, we revisit both datasets and reaffirm our findings. Through RedaC:T-seq reanalysis, we establish
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Retraction Notice to: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Karl E. Zahn, Ryan B. Jensen, Richard D. Wood, Sylvie Doublie
Abstract not available
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Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Nathanael A. Caveney, Grayson E. Rodriguez, Christoph Pollmann, Thomas Meyer, Marta T. Borowska, Steven C. Wilson, Nan Wang, Xinyu Xiang, Karsten D. Householder, Pingdong Tao, Leon L. Su, Robert A. Saxton, Jacob Piehler, K. Christopher Garcia
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localization Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Marius Hedtfeld, Alicia Dammers, Carolin Koerner, Andrea Musacchio
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Learning from chromatin reconstitution: Pioneer factors enabling nucleosome remodelers Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Ken Zaret
No Abstract
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SAFB restricts contact domain boundaries associated with L1 chimeric transcription Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Yaqiang Hong, Luyao Bie, Tao Zhang, Xiaohan Yan, Guangpu Jin, Zhuo Chen, Yang Wang, Xiufeng Li, Gaofeng Pei, Yongyan Zhang, Yantao Hong, Liang Gong, Pilong Li, Wei Xie, Yanfen Zhu, Xiaohua Shen, Nian Liu
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Three-step mechanism of promoter escape by RNA polymerase II Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Yumeng Zhan, Frauke Grabbe, Elisa Oberbeckmann, Christian Dienemann, Patrick Cramer
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Response to “Learning from chromatin reconstitution: Pioneering factors enabling nucleosome remodelers” Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Kami Ahmad, Sandipan Brahma, Steven Henikoff
Abstract not available
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An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains Mol. Cell (IF 16.0) Pub Date : 2024-04-09 Luigi Lerra, Martina Panatta, Dominik Bär, Isabella Zanini, Jennifer Yihong Tan, Agnese Pisano, Chiara Mungo, Célia Baroux, Vikram Govind Panse, Ana C. Marques, Raffaella Santoro
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Enhancer switching in cell lineage priming is linked to eRNA, Brg1’s AT-hook, and SWI/SNF recruitment Mol. Cell (IF 16.0) Pub Date : 2024-04-08 Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, McKenzie M. Murvin, Yue Lu, J. Mauro Calabrese, Blaine Bartholomew
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BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response Mol. Cell (IF 16.0) Pub Date : 2024-04-08 Haoyang Jiang, Tianpeng Zhang, Hardeep Kaur, Tao Shi, Aravind Krishnan, Youngho Kwon, Patrick Sung, Roger A. Greenberg
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Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle Mol. Cell (IF 16.0) Pub Date : 2024-04-08 Yeon Choi, Buyeon Um, Yongwoo Na, Jeesoo Kim, Jong-Seo Kim, V. Narry Kim
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DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability Mol. Cell (IF 16.0) Pub Date : 2024-04-02 Jin-Dong Hao, Qian-Lan Liu, Meng-Xia Liu, Xing Yang, Liu-Ming Wang, Si-Yi Su, Wen Xiao, Meng-Qi Zhang, Yi-Chang Zhang, Lan Zhang, Yu-Sheng Chen, Yun-Gui Yang, Jie Ren
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eIF4F is a thermo-sensing regulatory node in the translational heat shock response Mol. Cell (IF 16.0) Pub Date : 2024-03-27 Christine Desroches Altamirano, Moo-Koo Kang, Mareike A. Jordan, Tom Borianne, Irem Dilmen, Maren Gnädig, Alexander von Appen, Alf Honigmann, Titus M. Franzmann, Simon Alberti
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Molecular determinants and signaling effects of PKA RIα phase separation Mol. Cell (IF 16.0) Pub Date : 2024-03-26 Julia C. Hardy, Emily H. Pool, Jessica G.H. Bruystens, Xin Zhou, Qingrong Li, Daojia R. Zhou, Max Palay, Gerald Tan, Lisa Chen, Jaclyn L.C. Choi, Ha Neul Lee, Stefan Strack, Dong Wang, Susan S. Taylor, Sohum Mehta, Jin Zhang
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The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin Mol. Cell (IF 16.0) Pub Date : 2024-03-26 Andrey Damianov, Chia-Ho Lin, Jeffrey Huang, Lin Zhou, Yasaman Jami-Alahmadi, Parham Peyda, James Wohlschlegel, Douglas L. Black
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Modularity of PRC1 composition and chromatin interaction define condensate properties Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Stefan Niekamp, Sharon K. Marr, Theresa A. Oei, Radhika Subramanian, Robert E. Kingston
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Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Oleksandra Sirozh, Anabel Saez-Mas, Bomi Jung, Laura Sanchez-Burgos, Eduardo Zarzuela, Sara Rodrigo-Perez, Ivan Ventoso, Vanesa Lafarga, Oscar Fernandez-Capetillo
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Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Erica M. Hildebrand, Kirill Polovnikov, Bastiaan Dekker, Yu Liu, Denis L. Lafontaine, A. Nicole Fox, Ying Li, Sergey V. Venev, Leonid A. Mirny, Job Dekker
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Prajwal C. Boddu, Abhishek K. Gupta, Rahul Roy, Bárbara De La Peña Avalos, Anne Olazabal-Herrero, Nils Neuenkirchen, Joshua T. Zimmer, Namrata S. Chandhok, Darren King, Yasuhito Nannya, Seishi Ogawa, Haifan Lin, Matthew D. Simon, Eloise Dray, Gary M. Kupfer, Amit Verma, Karla M. Neugebauer, Manoj M. Pillai
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A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Yuleika G. Martinez Castillo, Chantell S. Evans
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How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Shasha Chong, Shawn Yoshida
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Integrating the response to stressed mitochondria Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Elliot Dine, Richard J. Youle
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Meet the authors: Jayoung Ku, Keonyong Lee, and Yoosik Kim Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Jayoung Ku, Keonyong Lee, Yoosik Kim
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H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation Mol. Cell (IF 16.0) Pub Date : 2024-03-20 Naoki Kubo, Poshen B. Chen, Rong Hu, Zhen Ye, Hiroyuki Sasaki, Bing Ren
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ERMA (TMEM94) is a P-type ATPase transporter for Mg2+ uptake in the endoplasmic reticulum Mol. Cell (IF 16.0) Pub Date : 2024-03-20 Neelanjan Vishnu, Manigandan Venkatesan, Travis R. Madaris, Mridula K. Venkateswaran, Kristen Stanley, Karthik Ramachandran, Adhishree Chidambaram, Abitha K. Madesh, Wenli Yang, Jyotsna Nair, Melanie Narkunan, Tharani Muthukumar, Varsha Karanam, Leroy C. Joseph, Amy Le, Ayodeji Osidele, M. Imran Aslam, John P. Morrow, May C. Malicdan, Peter B. Stathopulos, Muniswamy Madesh
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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis Mol. Cell (IF 16.0) Pub Date : 2024-03-19 Joel William Francis, Simone Hausmann, Sabeen Ikram, Kunlun Yin, Robert Mealey-Farr, Natasha Mahealani Flores, Annie Truc Trinh, Tourkian Chasan, Julia Thompson, Pawel Karol Mazur, Or Gozani
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A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53 Mol. Cell (IF 16.0) Pub Date : 2024-03-19 Guy Zoltsman, Thi Lieu Dang, Miriam Kuchersky, Ofrah Faust, Micael S. Silva, Tal Ilani, Anne S. Wentink, Bernd Bukau, Rina Rosenzweig
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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1 Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Tristen Wright, Meghan E. Turnis, Christy R. Grace, Xiao Li, Lauren A. Brakefield, Yong-Dong Wang, Haiyan Xu, Ewa Kaminska, Leslie K. Climer, Tresor O. Mukiza, Chi-Lun Chang, Tudor Moldoveanu, Joseph T. Opferman
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Pinki Gahlot, Bojana Kravic, Giulia Rota, Johannes van den Boom, Sophie Levantovsky, Nina Schulze, Elena Maspero, Simona Polo, Christian Behrends, Hemmo Meyer
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A kinetic dichotomy between mitochondrial and nuclear gene expression processes Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Erik McShane, Mary Couvillion, Robert Ietswaart, Gyan Prakash, Brendan M. Smalec, Iliana Soto, Autum R. Baxter-Koenigs, Karine Choquet, L. Stirling Churchman
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Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency Mol. Cell (IF 16.0) Pub Date : 2024-03-14 David Lando, Xiaoyan Ma, Yang Cao, Aleksandra Jartseva, Tim J. Stevens, Wayne Boucher, Nicola Reynolds, Bertille Montibus, Dominic Hall, Andreas Lackner, Ramy Ragheb, Martin Leeb, Brian D. Hendrich, Ernest D. Laue
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A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice Mol. Cell (IF 16.0) Pub Date : 2024-03-12 Xiaoding Ma, Jianli Yin, Longliang Qiao, Hang Wan, Xingwan Liu, Yang Zhou, Jiali Wu, Lingxue Niu, Min Wu, Xinyi Wang, Haifeng Ye
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Imprinted X chromosome inactivation at the gamete-to-embryo transition Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Chunyao Wei, Barry Kesner, Hao Yin, Jeannie T. Lee
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H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Jicheng Zhao, Jie Lan, Min Wang, Cuifang Liu, Zheng Fang, Aoqun Song, Tiantian Zhang, Liang Wang, Bing Zhu, Ping Chen, Juan Yu, Guohong Li
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Gergely Rona, Bearach Miwatani-Minter, Qingyue Zhang, Hailey V. Goldberg, Marc A. Kerzhnerman, Jesse B. Howard, Daniele Simoneschi, Ethan Lane, John W. Hobbs, Elizabeth Sassani, Andrew A. Wang, Sarah Keegan, Daniel J. Laverty, Cortt G. Piett, Lorinc S. Pongor, Miranda Li Xu, Joshua Andrade, Anish Thomas, Piotr Sicinski, Manor Askenazi, Beatrix Ueberheide, David Fenyö, Zachary D. Nagel, Michele Pagano
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Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Kyung Lock Kim, Gilbert J. Rahme, Viraat Y. Goel, Chadi A. El Farran, Anders S. Hansen, Bradley E. Bernstein