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CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity Immunity (IF 32.4) Pub Date : 2024-05-15 Neetu Srivastava, Hao Hu, Orion J. Peterson, Anthony N. Vomund, Marta Stremska, Mohammad Zaman, Shilpi Giri, Tiandao Li, Cheryl F. Lichti, Pavel N. Zakharov, Bo Zhang, Nada A. Abumrad, Yi-Guang Chen, Kodi S. Ravichandran, Emil R. Unanue, Xiaoxiao Wan
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Classical monocyte ontogeny dictates their functions and fates as tissue macrophages Immunity (IF 32.4) Pub Date : 2024-05-14 Sébastien Trzebanski, Jung-Seok Kim, Niss Larossi, Ayala Raanan, Daliya Kancheva, Jonathan Bastos, Montaser Haddad, Aryeh Solomon, Ehud Sivan, Dan Aizik, Jarmila Sekeresova Kralova, Mor Gross-Vered, Sigalit Boura-Halfon, Tsvee Lapidot, Ronen Alon, Kiavash Movahedi, Steffen Jung
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Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer Immunity (IF 32.4) Pub Date : 2024-05-14 Francesco De Sanctis, Silvia Dusi, Simone Caligola, Cristina Anselmi, Varvara Petrova, Barbara Rossi, Gabriele Angelini, Michael Erdeljan, Stefan Wöll, Anna Melissa Schlitter, Thomas Metzler, Katja Steiger, Zea Borok, Peter Bailey, Aline Bauer, Cornelia Halin, Federico Boschi, Rosalba Giugno, Stefania Canè, Rita Lawlor, Vincenzo Bronte
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Immunity by AS03ation: The natural adjuvantage Immunity (IF 32.4) Pub Date : 2024-05-14 Lena Hansen, Jenna J. Guthmiller
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate
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Non-canonical IKKs side with N4BP1 against the family Immunity (IF 32.4) Pub Date : 2024-05-14 Dominic De Nardo
The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 works in concert with the non-canonical IκB kinase (IKK) to limit activity of the IKK complex.
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Hair care: Stem cells control immune response during wound repair Immunity (IF 32.4) Pub Date : 2024-05-14 Shannon McCarthy, Judith Agudo
Stem cells heal wounds. In this issue of Immunity, Luan et al. demonstrate that epidermal stem cells orchestrate the recruitment of regulatory T (Treg) cells and neutrophils during wound healing. Treg cells facilitate a tolerogenic environment to protect epithelial regeneration while neutrophils promote inflammation to ward off infection.
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A new superhero, the intraepithelial mast cell, joins the “Guardians of the Gut” Immunity (IF 32.4) Pub Date : 2024-05-14 Aidil Zaini, Nicola L. Harris
The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating protective type 2 immune responses following intestinal helminth infection.
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Astrocytes remember inflammation Immunity (IF 32.4) Pub Date : 2024-05-14 Michael R. Williamson, Benjamin Deneen
Astrocytes respond to all forms of central nervous system maladies. In a recent issue of Nature, Lee et al. demonstrate that astrocytes encode inflammatory stimuli as epigenetic memory, which strengthens responses to subsequent stimuli and exacerbates pathology in disease models.
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Ironing out the role of ferroptosis in immunity Immunity (IF 32.4) Pub Date : 2024-05-14 Hannah N. Bell, Brent R. Stockwell, Weiping Zou
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many diseases. Oxidative stress is detectable in many types of regulated cell death, but only ferroptosis involves lipid peroxidation and iron dependency. Ferroptosis originates and propagates from several organelles, including the mitochondria, endoplasmic reticulum, Golgi, and lysosomes. Recent data have revealed that
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Platelets: Orchestrators of immunity in host defense and beyond Immunity (IF 32.4) Pub Date : 2024-05-14 Leo Nicolai, Kami Pekayvaz, Steffen Massberg
Platelets prevent blood loss during vascular injury and contribute to thrombus formation in cardiovascular disease. Beyond these classical roles, platelets are critical for the host immune response. They guard the vasculature against pathogens via specialized receptors, intracellular signaling cascades, and effector functions. Platelets also skew inflammatory responses by instructing innate immune
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Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance Immunity (IF 32.4) Pub Date : 2024-05-13 Tyler E. Billipp, Connie Fung, Lily M. Webeck, Derek B. Sargent, Matthew B. Gologorsky, Zuojia Chen, Margaret M. McDaniel, Darshan N. Kasal, John W. McGinty, Kaitlyn A. Barrow, Lucille M. Rich, Alessio Barilli, Mark Sabat, Jason S. Debley, Chuan Wu, Richard Myers, Michael R. Howitt, Jakob von Moltke
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The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation Immunity (IF 32.4) Pub Date : 2024-05-13 Takashi Imai, Juan Lin, Göksu Gökberk Kaya, Eunjin Ju, Vangelis Kondylis, Konstantinos Kelepouras, Gianmaria Liccardi, Chun Kim, Manolis Pasparakis
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Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity Immunity (IF 32.4) Pub Date : 2024-05-13 Marième Ndjim, Imène Gasmi, Fabien Herbert, Charlène Joséphine, Julie Bas, Ali Lamrani, Nathalie Coutry, Sylvain Henry, Valérie S. Zimmermann, Valérie Dardalhon, Marta Campillo Poveda, Evgenia Turtoi, Steeve Thirard, Luc Forichon, Alicia Giordano, Claire Ciancia, Zeinab Homayed, Julie Pannequin, Collette Britton, Eileen Devaney, Philippe Jay
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Structural transitions enable interleukin-18 maturation and signaling Immunity (IF 32.4) Pub Date : 2024-05-10 Ying Dong, Jeffrey P. Bonin, Pascal Devant, Zhuoyi Liang, Alexander I.M. Sever, Julian Mintseris, James M. Aramini, Gang Du, Stephen P. Gygi, Jonathan C. Kagan, Lewis E. Kay, Hao Wu
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Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers Immunity (IF 32.4) Pub Date : 2024-05-08 Sheenam Verma, Matthew J. Dufort, Tayla M. Olsen, Samantha Kimmel, Jasmine C. Labuda, Sam Scharffenberger, Andrew T. McGuire, Oliver J. Harrison
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma Immunity (IF 32.4) Pub Date : 2024-05-03 Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu, Fabio Scirocchi, Delia Scocozza, Barbara Peixoto, Angelica Pace, Luca D’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Filippo Veglia
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Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation Immunity (IF 32.4) Pub Date : 2024-05-01 Marleen Bérouti, Katja Lammens, Matthias Heiss, Larissa Hansbauer, Stefan Bauernfried, Jan Stöckl, Francesca Pinci, Ignazio Piseddu, Wilhelm Greulich, Meiyue Wang, Christophe Jung, Thomas Fröhlich, Thomas Carell, Karl-Peter Hopfner, Veit Hornung
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Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint Immunity (IF 32.4) Pub Date : 2024-05-01 Matthew P. Mulè, Andrew J. Martins, Foo Cheung, Rohit Farmer, Brian A. Sellers, Juan A. Quiel, Arjun Jain, Yuri Kotliarov, Neha Bansal, Jinguo Chen, Pamela L. Schwartzberg, John S. Tsang
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N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation Immunity (IF 32.4) Pub Date : 2024-05-01 Alexander D. Gitlin, Allie Maltzman, Yuzuka Kanno, Klaus Heger, Rohit Reja, Alexander F. Schubert, Linsey J. Wierciszewski, Homer Pantua, Sharookh B. Kapadia, Seth F. Harris, Joshua D. Webster, Kim Newton, Vishva M. Dixit
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A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification Immunity (IF 32.4) Pub Date : 2024-05-01 Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Victor Bass, Jaanam Gopalakrishnan, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Lauren Reich, Chen Yao, Hong-Wei Sun, Stephen R. Brooks, Kan Jiang, Vijayaraj Nagarajan, Yongbing Zhao, Seolkyoung Jung, Rachael Phillips, Yohei Mikami, Caleb A. Lareau, Han-Yu Shih
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Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis Immunity (IF 32.4) Pub Date : 2024-04-30 Gang Wang, Andrés R. Muñoz-Rojas, Raul German Spallanzani, Ruth A. Franklin, Christophe Benoist, Diane Mathis
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Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut Immunity (IF 32.4) Pub Date : 2024-04-26 Arundhoti Das, Gustavo Ulises Martinez-Ruiz, Nicolas Bouladoux, Apollo Stacy, Josquin Moraly, Maria Vega-Sendino, Yongge Zhao, Marieke Lavaert, Yi Ding, Abigail Morales-Sanchez, Christelle Harly, Mina O. Seedhom, Raj Chari, Parirokh Awasthi, Tomoko Ikeuchi, Yueqiang Wang, Jinfang Zhu, Niki M. Moutsopoulos, WanJun Chen, Jonathan W. Yewdell, Avinash Bhandoola
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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment Immunity (IF 32.4) Pub Date : 2024-04-26 Jingyun Luan, Cynthia Truong, Aleksandra Vuchkovska, Weijie Guo, Jennifer Good, Bijun Liu, Audrey Gang, Nicole Infarinato, Katherine Stewart, Lisa Polak, Hilda Amalia Pasolli, Emma Andretta, Alexander Y. Rudensky, Elaine Fuchs, Yuxuan Miao
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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses Immunity (IF 32.4) Pub Date : 2024-04-25 Rashmi Ray, Faez Amokrane Nait Mohamed, Daniel P. Maurer, Jiachen Huang, Berk A. Alpay, Larance Ronsard, Zhenfei Xie, Julianna Han, Monica Fernandez-Quintero, Quynh Anh Phan, Rebecca L. Ursin, Mya Vu, Kathrin H. Kirsch, Thavaleak Prum, Victoria C. Rosado, Thalia Bracamonte-Moreno, Vintus Okonkwo, Julia Bals, Caitlin McCarthy, Usha Nair, Daniel Lingwood
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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages Immunity (IF 32.4) Pub Date : 2024-04-18 Jun Xiao, Shuang Wang, Longlong Chen, Xinyu Ding, Yuanhao Dang, Mingshun Han, Yuxiao Zheng, Huan Shen, Sifan Wu, Mingchang Wang, Dan Yang, Na Li, Chen Dong, Miao Hu, Chen Su, Weiyun Li, Lijian Hui, Youqiong Ye, Huiru Tang, Bin Wei, Hongyan Wang
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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages Immunity (IF 32.4) Pub Date : 2024-04-17 Jay K. Mandula, Rosa A. Sierra-Mondragon, Rachel V. Jimenez, Darwin Chang, Eslam Mohamed, Shiun Chang, Julio A. Vazquez-Martinez, Yu Cao, Carmen M. Anadon, Sae Bom Lee, Satyajit Das, Léo Rocha-Munguba, Vincent M. Pham, Roger Li, Ahmad A. Tarhini, Muhammad Furqan, William Dalton, Michelle Churchman, Carlos M. Moran-Segura, Jonathan Nguyen, Paulo C. Rodriguez
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Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity Immunity (IF 32.4) Pub Date : 2024-04-12 Liu Yang, Huabin He, Xue-Kun Guo, Jiali Wang, Wenwen Wang, Da Li, Shaonan Liang, Feng Shao, Wanli Liu, Xiaoyu Hu
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Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction Immunity (IF 32.4) Pub Date : 2024-04-12 Shuai Liu, Yaqiang Cao, Kairong Cui, Gang Ren, Tingting Zhao, Xuezheng Wang, Danping Wei, Zuojia Chen, Rama Krishna Gurram, Chengyu Liu, Chuan Wu, Jinfang Zhu, Keji Zhao
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Vaccine adjuvants: Tailoring innate recognition to send the right message Immunity (IF 32.4) Pub Date : 2024-04-09 Ed C. Lavelle, Craig P. McEntee
Adjuvants play pivotal roles in vaccine development, enhancing immunization efficacy through prolonged retention and sustained release of antigen, lymph node targeting, and regulation of dendritic cell activation. Adjuvant-induced activation of innate immunity is achieved via diverse mechanisms: for example, adjuvants can serve as direct ligands for pathogen recognition receptors or as inducers of
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Control of adaptive immunity by pattern recognition receptors Immunity (IF 32.4) Pub Date : 2024-04-09 Shaina L. Carroll, Chandrashekhar Pasare, Gregory M. Barton
One of the most significant conceptual advances in immunology in recent history is the recognition that signals from the innate immune system are required for induction of adaptive immune responses. Two breakthroughs were critical in establishing this paradigm: the identification of dendritic cells (DCs) as the cellular link between innate and adaptive immunity and the discovery of pattern recognition
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Stressed out neutrophils drive metastasis Immunity (IF 32.4) Pub Date : 2024-04-09 Federico Lupo, Seth B. Coffelt
Stress hormones can contribute to cancer progression, but how immune cells play a role in this process is unclear. In a recent study in Cancer Cell, He et al. showed that glucocorticoids potentiate metastasis by skewing neutrophils toward pro-tumorigenic functions.
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The NLR family of innate immune and cell death sensors Immunity (IF 32.4) Pub Date : 2024-04-09 Balamurugan Sundaram, Rebecca E. Tweedell, Sivakumar Prasanth Kumar, Thirumala-Devi Kanneganti
Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition receptors that detect a wide variety of pathogenic and sterile triggers. Activation of specific NLRs initiates pro- or anti-inflammatory signaling cascades and the formation of inflammasomes—multi-protein complexes that
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Depression: Monocytes on my mind Immunity (IF 32.4) Pub Date : 2024-04-09 Gisela Paola Lazzarino, David Engblom
Activation of the peripheral immune system contributes to stress-related neuropsychiatric symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social avoidance is mediated by monocyte-derived MMP8 that remodels the extracellular space of the nucleus accumbens.
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Innate immune activation in neurodegenerative diseases Immunity (IF 32.4) Pub Date : 2024-04-09 Sergio Castro-Gomez, Michael T. Heneka
Activation of the innate immune system following pattern recognition receptor binding has emerged as one of the major pathogenic mechanisms in neurodegenerative disease. Experimental, epidemiological, pathological, and genetic evidence underscores the meaning of innate immune activation during the prodromal as well as clinical phases of several neurodegenerative disorders including Alzheimer’s disease
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Gums make IL-23, no professionals needed Immunity (IF 32.4) Pub Date : 2024-04-09 Mandy J. McGeachy
IL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic regulation of IL-17-associated inflammation.
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Sensory neurons: An integrated component of innate immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Liwen Deng, Jacob E. Gillis, Isaac M. Chiu, Daniel H. Kaplan
The sensory nervous system possesses the ability to integrate exogenous threats and endogenous signals to mediate downstream effector functions. Sensory neurons have been shown to activate or suppress host defense and immunity against pathogens, depending on the tissue and disease state. Through this lens, pro- and anti-inflammatory neuroimmune effector functions can be interpreted as evolutionary
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The conceptual foundations of innate immunity: Taking stock 30 years later Immunity (IF 32.4) Pub Date : 2024-04-09 Thomas Pradeu, Bart P.H.J. Thomma, Stephen E. Girardin, Bruno Lemaitre
While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis
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Hostile bile limits anti-cancer immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Pavitha Parathan, Lisa A. Mielke
Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation of calcium efflux.
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Myeloid C-type lectin receptors in innate immune recognition Immunity (IF 32.4) Pub Date : 2024-04-09 Caetano Reis e Sousa, Sho Yamasaki, Gordon D. Brown
C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and markers of altered self
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Decoding Toll-like receptors: Recent insights and perspectives in innate immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Taro Kawai, Moe Ikegawa, Daisuke Ori, Shizuo Akira
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs). TLRs, categorized into cell surface and endosomal subfamilies, recognize diverse PAMPs, and structural elucidation of TLRs and PAMP complexes has revealed their intricate mechanisms
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Physiological functions of RIG-I-like receptors Immunity (IF 32.4) Pub Date : 2024-04-09 Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune responses and have immense physiological importance. In this review, we first summarize the interferon system and innate immunity, which constitute primary and secondary responses. Next, the molecular structure of RLRs and the mechanism of sensing non-self RNA are described. Usually, self RNA is refractory to the RLR;
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DAMPs and DAMP-sensing receptors in inflammation and diseases Immunity (IF 32.4) Pub Date : 2024-04-09 Ming Ma, Wei Jiang, Rongbin Zhou
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules produced in cellular damage or stress, and they can activate the innate immune system. DAMPs contain multiple types of molecules, including nucleic acids, proteins, ions, glycans, and metabolites. Although these endogenous molecules do not trigger immune response under steady-state condition, they may undergo changes in distribution
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New frontiers in the cGAS-STING intracellular DNA-sensing pathway Immunity (IF 32.4) Pub Date : 2024-04-09 Steve Dvorkin, Stephanie Cambier, Hannah E. Volkman, Daniel B. Stetson
The cGAS-STING intracellular DNA-sensing pathway has emerged as a key element of innate antiviral immunity and a promising therapeutic target. The existence of an innate immune sensor that can be activated by any double-stranded DNA (dsDNA) of any origin raises fundamental questions about how cGAS is regulated and how it responds to “foreign” DNA while maintaining tolerance to ubiquitous self-DNA.
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Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection Immunity (IF 32.4) Pub Date : 2024-04-08 Lucy Cooper, Hui Xu, Jack Polmear, Liam Kealy, Christopher Szeto, Ee Shan Pang, Mansi Gupta, Alana Kirn, Justin J. Taylor, Katherine J.L. Jackson, Benjamin J. Broomfield, Angela Nguyen, Catarina Gago da Graça, Nicole La Gruta, Daniel T. Utzschneider, Joanna R. Groom, Luciano Martelotto, Ian A. Parish, Meredith O’Keeffe, Christopher D. Scharer, Kim L. Good-Jacobson
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Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance Immunity (IF 32.4) Pub Date : 2024-03-21 Clinton O. Ogega, Nicole E. Skinner, Marta V. Schoenle, Xander E. Wilcox, Nicole Frumento, Desiree A. Wright, Harry T. Paul, Ariadne Sinnis-Bourozikas, Kaitlyn E. Clark, Alexis Figueroa, Pamela J. Bjorkman, Stuart C. Ray, Andrew I. Flyak, Justin R. Bailey
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Epithelial-derived interleukin-23 promotes oral mucosal immunopathology Immunity (IF 32.4) Pub Date : 2024-03-20 Tae Sung Kim, Tomoko Ikeuchi, Vasileios Ionas Theofilou, Drake Winslow Williams, Teresa Greenwell-Wild, Armond June, Emmanuel E. Adade, Lu Li, Loreto Abusleme, Nicolas Dutzan, Yao Yuan, Laurie Brenchley, Nicolas Bouladoux, Yosuke Sakamachi, NIDCD/NIDCR Genomics and Computational Biology Core, Robert J. Palmer Jr., Ramiro Iglesias-Bartolome, Giorgio Trinchieri, Stavros Garantziotis, Yasmine Belkaid
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Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers Immunity (IF 32.4) Pub Date : 2024-03-20 Laila Shehata, Christopher D. Thouvenel, Brian D. Hondowicz, Lucia A. Pew, Gretchen Harms Pritchard, David J. Rawlings, Jinyong Choi, Marion Pepper
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Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants Immunity (IF 32.4) Pub Date : 2024-03-14 Timothy S. Johnston, Shuk Hang Li, Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek, David B. Reeg, Daniel C. Douek, E. John Wherry, Scott E. Hensley
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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans Immunity (IF 32.4) Pub Date : 2024-03-14 M. Alejandra Tortorici, Amin Addetia, Albert J. Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions Immunity (IF 32.4) Pub Date : 2024-03-12 Jingjing Cong, Pianpian Liu, Zili Han, Wei Ying, Chaoliang Li, Yifei Yang, Shuling Wang, Jianbo Yang, Fei Cao, Juntao Shen, Yu Zeng, Yu Bai, Congzhao Zhou, Lilin Ye, Rongbin Zhou, Chunjun Guo, Chunlei Cang, Dennis L. Kasper, Xinyang Song, Lei Dai, Linfeng Sun, Wen Pan, Shu Zhu
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Dual checkpoint T(h1)eamwork makes the anti-cancer dream work Immunity (IF 32.4) Pub Date : 2024-03-12 Alisa Dietl, Anna Ralser, Karin Pelka
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IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging Immunity (IF 32.4) Pub Date : 2024-03-12 Conor M. Finlay, Judith E. Allen
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Predicting plasma cell retention and loss over a lifetime Immunity (IF 32.4) Pub Date : 2024-03-12 Marcus J. Robinson, David M. Tarlinton
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Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases Immunity (IF 32.4) Pub Date : 2024-03-12 Kate E. Lawlor, James M. Murphy, James E. Vince
Diverse inflammatory conditions, from infections to autoimmune disease, are often associated with cellular damage and death. Apoptotic cell death has evolved to minimize its inflammatory potential. By contrast, necrotic cell death via necroptosis and pyroptosis—driven by membrane-damaging MLKL and gasdermins, respectively—can both initiate and propagate inflammatory responses. In this review, we provide
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Complement-ary protection for all ages Immunity (IF 32.4) Pub Date : 2024-03-12 Geongoo Han, Shipra Vaishnava
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The price of P2X7R freedom is neuroinflammation Immunity (IF 32.4) Pub Date : 2024-03-12 Mingqian Fang, Ren Lai
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Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells Immunity (IF 32.4) Pub Date : 2024-03-12 Wei Bu, Ashish Kumar, Nathan L. Board, JungHyun Kim, Kennichi Dowdell, Shu Zhang, Yona Lei, Anna Hostal, Tammy Krogmann, Yanmei Wang, Stefania Pittaluga, Joseph Marcotrigiano, Jeffrey I. Cohen
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with B cell lymphomas. EBV glycoprotein 42 (gp42) binds HLA class II and activates membrane fusion with B cells. We isolated gp42-specific monoclonal antibodies (mAbs), A10 and 4C12, which use distinct mechanisms to neutralize virus infection. mAb A10 was more potent than the only known neutralizing gp42 mAb, F-2-1, in neutralizing
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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer Immunity (IF 32.4) Pub Date : 2024-03-12 Acacia N. Shouse, Kathryn M. LaPorte, Thomas R. Malek
Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which
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Differentiation route determines the functional outputs of adult megakaryopoiesis Immunity (IF 32.4) Pub Date : 2024-03-05 Jing-Jing Li, Jingkun Liu, Yunqian Evelyn Li, Lin Veronica Chen, Hui Cheng, Yueying Li, Tao Cheng, Qian-Fei Wang, Bo O. Zhou
Emerging evidence has revealed a direct differentiation route from hematopoietic stem cells to megakaryocytes (direct route), in addition to the classical differentiation route through a series of restricted hematopoietic progenitors (stepwise route). This raises the question of the importance of two alternative routes for megakaryopoiesis. Here, we developed fate-mapping systems to distinguish the
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Tuning of plasma cell lifespan by competition explains the longevity and heterogeneity of antibody persistence Immunity (IF 32.4) Pub Date : 2024-03-05 Benjamin D. Simons, Omer Karin
Plasma cells that emerge after infection or vaccination exhibit heterogeneous lifespans; most survive for days to months, whereas others persist for decades, providing antigen-specific long-term protection. We developed a mathematical framework to explore the dynamics of plasma cell removal and its regulation by survival factors. Analyses of antibody persistence following hepatitis A and B and HPV