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Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids Cell Stem Cell (IF 23.9) Pub Date : 2024-05-15 Lan Dao, Zhen You, Lu Lu, Tianyang Xu, Avijite Kumer Sarkar, Hui Zhu, Miao Liu, Riccardo Calandrelli, George Yoshida, Pei Lin, Yifei Miao, Sarah Mierke, Srijan Kalva, Haining Zhu, Mingxia Gu, Sudhakar Vadivelu, Sheng Zhong, L. Frank Huang, Ziyuan Guo
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Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics Cell Stem Cell (IF 23.9) Pub Date : 2024-05-15 Suzan Stelloo, Maria Teresa Alejo-Vinogradova, Charlotte A.G.H. van Gelder, Dick W. Zijlmans, Marek J. van Oostrom, Juan Manuel Valverde, Lieke A. Lamers, Teja Rus, Paula Sobrevals Alcaraz, Tilman Schäfers, Cristina Furlan, Pascal W.T.C. Jansen, Marijke P.A. Baltissen, Katharina F. Sonnen, Boudewijn Burgering, Maarten A.F.M. Altelaar, Harmjan R. Vos, Michiel Vermeulen
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Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells Cell Stem Cell (IF 23.9) Pub Date : 2024-05-15 Paul V. Dellorusso, Melissa A. Proven, Fernando J. Calero-Nieto, Xiaonan Wang, Carl A. Mitchell, Felix Hartmann, Meelad Amouzgar, Patricia Favaro, Andrew DeVilbiss, James W. Swann, Theodore T. Ho, Zhiyu Zhao, Sean C. Bendall, Sean Morrison, Berthold Göttgens, Emmanuelle Passegué
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Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells Cell Stem Cell (IF 23.9) Pub Date : 2024-05-15 Tengku Ibrahim Maulana, Claudia Teufel, Madalena Cipriano, Julia Roosz, Lisa Lazarevski, Francijna E. van den Hil, Lukas Scheller, Valeria Orlova, André Koch, Michael Hudecek, Miriam Alb, Peter Loskill
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Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts Cell Death Differ. (IF 12.4) Pub Date : 2024-05-14 Himanshi Agarwal, Perry Tal, Naomi Goldfinger, Esita Chattopadhyay, David Malkin, Varda Rotter, Ayush Attery
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Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING Mol. Cell (IF 16.0) Pub Date : 2024-05-14 Tohru Takaki, Rhona Millar, Crispin T. Hiley, Simon J. Boulton
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Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia Nat. Cell Biol. (IF 21.3) Pub Date : 2024-05-14 Lin Yang, Zhaoru Zhang, Penglei Jiang, Delin Kong, Zebin Yu, Danrong Shi, Yingli Han, Ertuo Chen, Weiyan Zheng, Jie Sun, Yanmin Zhao, Yi Luo, Jimin Shi, Hangping Yao, He Huang, Pengxu Qian
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Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome Cell Death Differ. (IF 12.4) Pub Date : 2024-05-13 Jiangxue Cai, Chenxuan Li, Suyuan Liu, Meiling Tan, Yiran Sun, Xiaoxiao Sun, Miaoxin Yang, Bin He
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Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer Cancer Cell (IF 50.3) Pub Date : 2024-05-13 Daniiar Dyikanov, Aleksandr Zaitsev, Tatiana Vasileva, Iris Wang, Arseniy A. Sokolov, Evgenii S. Bolshakov, Alena Frank, Polina Turova, Olga Golubeva, Anna Gantseva, Anna Kamysheva, Polina Shpudeiko, Ilya Krauz, Mary Abdou, Madison Chasse, Tori Conroy, Nicholas R. Merriam, Julia E. Alesse, Noel English, Boris Shpak, Michael F. Goldberg
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Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis Cancer Cell (IF 50.3) Pub Date : 2024-05-13 Tarun Gupta, Agne Antanaviciute, Chloe Hyun-Jung Lee, Rosana Ottakandathil Babu, Anna Aulicino, Zoe Christoforidou, Paulina Siejka-Zielinska, Caitlin O’Brien-Ball, Hannah Chen, David Fawkner-Corbett, Ana Sousa Geros, Esther Bridges, Colleen McGregor, Nicole Cianci, Eve Fryer, Nasullah Khalid Alham, Marta Jagielowicz, Ana Mafalda Santos, Martin Fellermeyer, Simon J. Davis, Alison Simmons
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Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease Nat. Cell Biol. (IF 21.3) Pub Date : 2024-05-13 Ranen Aviner, Ting-Ting Lee, Vincent B. Masto, Kathy H. Li, Raul Andino, Judith Frydman
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Integrator and U1 snRNPs steer Pol II in the right direction Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-05-10 Eytan Zlotorynski
Cleavage of promoter-upstream antisense RNAs by the Integrator complex supports the preferential transcription of pre-mRNAs.
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RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis Cell Death Differ. (IF 12.4) Pub Date : 2024-05-11 Jelle Huysentruyt, Wolf Steels, Mario Ruiz Perez, Bruno Verstraeten, Mike Vadi, Tatyana Divert, Kayleigh Flies, Nozomi Takahashi, Bart N. Lambrecht, Wim Declercq, Tom Vanden Berghe, Jonathan Maelfait, Peter Vandenabeele, Peter Tougaard
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation Cell Stem Cell (IF 23.9) Pub Date : 2024-05-10 Pratik N.P. Singh, Wei Gu, Shariq Madha, Allen W. Lynch, Paloma Cejas, Ruiyang He, Swarnabh Bhattacharya, Miguel Muñoz Gomez, Matthew G. Oser, Myles Brown, Henry W. Long, Clifford A. Meyer, Qiao Zhou, Ramesh A. Shivdasani
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Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells Cell Stem Cell (IF 23.9) Pub Date : 2024-05-10 Mahliyah Adkins-Threats, Sumimasa Arimura, Yang-Zhe Huang, Margarita Divenko, Sarah To, Heather Mao, Yongji Zeng, Jenie Y. Hwang, Joseph R. Burclaff, Shilpa Jain, Jason C. Mills
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A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion Cell Metab. (IF 29.0) Pub Date : 2024-05-09 Radiana Ferrero, Pernille Yde Rainer, Marie Rumpler, Julie Russeil, Magda Zachara, Joern Pezoldt, Guido van Mierlo, Vincent Gardeux, Wouter Saelens, Daniel Alpern, Lucie Favre, Nathalie Vionnet, Styliani Mantziari, Tobias Zingg, Nelly Pitteloud, Michel Suter, Maurice Matter, Kai-Uwe Schlaudraff, Carles Canto, Bart Deplancke
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Understanding the complexity of p53 in a new era of tumor suppression Cancer Cell (IF 50.3) Pub Date : 2024-05-09 Yanqing Liu, Zhenyi Su, Omid Tavana, Wei Gu
p53 was discovered 45 years ago as an SV40 large T antigen binding protein, coded by the most frequently mutated TP53 gene in human cancers. As a transcription factor, p53 is tightly regulated by a rich network of post-translational modifications to execute its diverse functions in tumor suppression. Although early studies established p53-mediated cell-cycle arrest, apoptosis, and senescence as the
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Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke Cell Death Differ. (IF 12.4) Pub Date : 2024-05-08 Chao Wei, Zhongnan Xiao, Yanling Zhang, Zhaoli Luo, Dongyang Liu, Liye Hu, Danmin Shen, Meng Liu, Lei Shi, Xiaotong Wang, Ting Lan, Qingqing Dai, Jing Liu, Wen Chen, Yurui Zhang, Qingyu Sun, Weihua Wu, Peipei Wang, Chenguang Zhang, Junchi Hu, Chu Wang, Fei Yang, Qian Li
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Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling Dev. Cell (IF 11.8) Pub Date : 2024-05-08 Guanqun Ren, Yime Zhang, Jiamin Liu, Wenwen Cheng, Di Wu, Mengwei Han, Yanyu Zeng, Xingyu Zhao, Luni Hu, Min Zeng, Rama Krishna Gurram, Xiaole Hu, Bo Zhou, Zhiyuan Hou, Jinfang Zhu, Wenfei Jin, Chao Zhong
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Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity Cell Stem Cell (IF 23.9) Pub Date : 2024-05-08 Jun Shen, Shuzhen Lyu, Yingxi Xu, Shuo Zhang, Li Li, Jinze Li, Junli Mou, Leling Xie, Kejing Tang, Wei Wen, Xuemei Peng, Ying Yang, Yu Shi, Xinjie Li, Min Wang, Xin Li, Jianxiang Wang, Tao Cheng
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DNMT1 regulates human erythropoiesis by modulating cell cycle and endoplasmic reticulum stress in a stage-specific manner Cell Death Differ. (IF 12.4) Pub Date : 2024-05-08 Qianqian Yang, Lixiang Chen, Hengchao Zhang, Mengjia Li, Lei Sun, Xiuyun Wu, Huizhi Zhao, Xiaoli Qu, Xiuli An, Ting Wang
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Current and novel approaches in yeast cell death research Cell Death Differ. (IF 12.4) Pub Date : 2024-05-07 Susana R. Chaves, António Rego, Cátia Santos-Pereira, Maria João Sousa, Manuela Côrte-Real
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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins Mol. Cell (IF 16.0) Pub Date : 2024-05-08 Jia Ji, Meng-Ke Cui, Rong Zou, Ming-Zhi Wu, Man-Xi Ge, Jiqiang Li, Zai-Rong Zhang
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Opposing polarity domains provide direction and play a role in cell division in plant growth Dev. Cell (IF 11.8) Pub Date : 2024-05-06 Olivia Hazelwood, M. Arif Ashraf
Polar localization of proteins is important for plant growth and development. Identifying the interactors of polarized proteins provides spatial information and cell-type functions. In this issue of Developmental Cell, Wallner et al. (2024) utilize opposing polarity domain proteins to identify interactors and their functions during cell division in Arabidopsis stomata.
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Tracing embryonic hematopoiesis guides induction of pluripotent stem cells to hematopoietic progenitors Dev. Cell (IF 11.8) Pub Date : 2024-05-06 Xinjian Mao, Linheng Li
In this issue of Developmental Cell, Fowler et al. applied genetic lineage-tracing mouse models to support the notion that artery endothelial cells are the predominant source of hematopoietic stem cells. They leveraged this and developed a method capable of efficiently differentiating human pluripotent stem cells into HLF+HOXA+ hematopoietic progenitors.
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Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Tim F. Dorweiler, Arjun Singh, Aditya Ganju, Todd A. Lydic, Louis C. Glazer, Richard N. Kolesnick, Julia V. Busik
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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1 Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Nogayhan Seymen, Pierluigi Ramadori, Vera Joerke, Laimdota Zizmare, David Aicher, Indresh K. Gopalsamy, Winnie Fong, Jan Kosla, Enrico Focaccia, Xin Li, Suhail Yousuf, Tjeerd Sijmonsma, Mohammad Rahbari, Katharina S. Kommoss, Adrian Billeter, Sandra Prokosch, Ulrike Rothermel, Mathias Heikenwalder
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Gut microbial alterations in arginine metabolism determine bone mechanical adaptation Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Dan Wang, Jing Cai, Qilin Pei, Zedong Yan, Feng Zhu, Zhe Zhao, Ruobing Liu, Xiangyang Guo, Tao Sun, Juan Liu, Yulan Tian, Hongbo Liu, Xi Shao, Jinghui Huang, Xiaoxia Hao, Qi Chang, Zhuojing Luo, Da Jing
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Qingwen Qian, Mark Li, Zeyuan Zhang, Shannon W. Davis, Kamal Rahmouni, Andrew W. Norris, Huojun Cao, Wen-Xing Ding, Gökhan S. Hotamisligil, Ling Yang
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Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Qiang Cai, Yihao Tian, Quazi T.H. Shubhra
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase’s crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
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Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Shane J.F. Cronin
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.
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Understanding osteokine biology Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Mone Zaidi, Samir Zaidi, Tony Yuen
Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress.
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Branching out beyond canonical brown adipocyte function Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Helaina Von Bank, Judith Simcox
Brown adipose tissue has long been functionally characterized as an organ that regulates thermogenesis, body weight set point, and glucose homeostasis. In the May 9, 2024, issue of Cell, Verkerke et al. discover a novel function for brown adipose tissue in processing branched-chain amino acids into antioxidant metabolites that enter the circulation and regulate insulin signaling in the liver.
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Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Tao Bo, Ling Gao, Zhenyu Yao, Shanshan Shao, Xuemin Wang, Christopher G. Proud, Jiajun Zhao
Insulin resistance (IR) is a major pathogenic factor in the progression of MASLD. In the liver, insulin suppresses gluconeogenesis and enhances de novo lipogenesis (DNL). During IR, there is a defect in insulin-mediated suppression of gluconeogenesis, but an unrestrained increase in hepatic lipogenesis persists. The mechanism of increased hepatic steatosis in IR is unclear and remains controversial
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ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum Cell Stem Cell (IF 23.9) Pub Date : 2024-05-07 Catarina Martins-Costa, Andrea Wiegers, Vincent A. Pham, Jaydeep Sidhaye, Balint Doleschall, Maria Novatchkova, Thomas Lendl, Marielle Piber, Angela Peer, Paul Möseneder, Marlene Stuempflen, Siu Yu A. Chow, Rainer Seidl, Daniela Prayer, Romana Höftberger, Gregor Kasprian, Yoshiho Ikeuchi, Nina S. Corsini, Jürgen A. Knoblich
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Mammalian IRE1α dynamically and functionally coalesces with stress granules Nat. Cell Biol. (IF 21.3) Pub Date : 2024-05-07 Songzi Liu, Xiaoge Zhang, Xin Yao, Guan Wang, Shijia Huang, Peng Chen, Mingliang Tang, Jie Cai, Zhuyin Wu, Yiliang Zhang, Rongzhi Xu, Kai Liu, Kangmin He, Yan Wang, Lei Jiang, Qiong A. Wang, Liangyou Rui, Jianmiao Liu, Yong Liu
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Cell-intrinsic and microenvironmental determinants of metastatic colonization Nat. Cell Biol. (IF 21.3) Pub Date : 2024-05-07 Arthur W. Lambert, Yun Zhang, Robert A. Weinberg
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Cerebral organoids display dynamic clonal growth and tunable tissue replenishment Nat. Cell Biol. (IF 21.3) Pub Date : 2024-05-07 Dominik Lindenhofer, Simon Haendeler, Christopher Esk, Jamie B. Littleboy, Clarisse Brunet Avalos, Julia Naas, Florian G. Pflug, Eline G. P. van de Ven, Daniel Reumann, Alexandre D. Baffet, Arndt von Haeseler, Jürgen A. Knoblich
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A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis Cell Death Differ. (IF 12.4) Pub Date : 2024-05-07 Yu-Che Cheng, Jack Dalit Acedera, Yi-Ju Li, Sheau-Yann Shieh
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Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor Cell Stem Cell (IF 23.9) Pub Date : 2024-05-03 Tingwei Guo, Fei Pei, Mingyi Zhang, Takahiko Yamada, Jifan Feng, Junjun Jing, Thach-Vu Ho, Yang Chai
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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex Mol. Cell (IF 16.0) Pub Date : 2024-05-03 Dimitrios Papadopoulos, Stefanie Anh Ha, Daniel Fleischhauer, Leonie Uhl, Timothy J. Russell, Ivan Mikicic, Katharina Schneider, Annika Brem, Omkar Rajendra Valanju, Giacomo Cossa, Peter Gallant, Christina Schuelein-Voelk, Hans Michael Maric, Petra Beli, Gabriele Büchel, Seychelle M. Vos, Martin Eilers
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A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development Cell Metab. (IF 29.0) Pub Date : 2024-05-03 Zhijuan Hu, Liang Yang, Maolei Zhang, Haite Tang, Yile Huang, Yujie Su, Yingzhe Ding, Chong Li, Mengfei Wang, Yunhao Zhou, Qing Zhang, Liman Guo, Yue Wu, Qianqian Wang, Ning Liu, Haoran Kang, Yi Wu, Deyang Yao, Yukun Li, Zifeng Ruan, Xingguo Liu
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The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Thomas Mortimer, Valentina M. Zinna, Muge Atalay, Carmelo Laudanna, Oleg Deryagin, Guillem Posas, Jacob G. Smith, Elisa García-Lara, Mireia Vaca-Dempere, Leonardo Vinícius Monteiro de Assis, Isabel Heyde, Kevin B. Koronowski, Paul Petrus, Carolina M. Greco, Stephen Forrow, Henrik Oster, Paolo Sassone-Corsi, Patrick-Simon Welz, Pura Muñoz-Cánoves, Salvador Aznar Benitah
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ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification Nat. Cell Biol. (IF 21.3) Pub Date : 2024-05-03 Seungbok Yang, Mahdi Golkaram, Seyoun Oh, Yujeong Oh, Yoonjae Cho, Jeehyun Yoe, Sungeun Ju, Matthew A. Lalli, Seung-Yeol Park, Yoontae Lee, Jiwon Jang
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H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation Cell Death Differ. (IF 12.4) Pub Date : 2024-05-02 Na Deng, Gaizhen Li, Leilei Zhang, Peiran Wang, Mengying Liu, Bo He, Yedong Tang, Han Cai, Jinhua Lu, Haibin Wang, Wenbo Deng, Haili Bao, Shuangbo Kong
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The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics Mol. Cell (IF 16.0) Pub Date : 2024-05-03 Sook Wah Yee, Christian B. Macdonald, Darko Mitrovic, Xujia Zhou, Megan L. Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan D. Trinidad, Swati S. More, Linda Kachuri, John S. Witte, Lucie Delemotte, Kathleen M. Giacomini, Willow Coyote-Maestas
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DDX21: The link between m6A and R-loops Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Guillaume Lavergne, Jean-Yves Roignant
In this issue of Molecular Cell, Hao et al.1 demonstrate that the RNA helicase DDX21 recruits the m6A methyltransferase complex to R-loops, ensuring proper transcription termination and genome stability.
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eIF4G as a switch for heat shock mRNA translation Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Yi Liu, Peiguo Yang
The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al.1 demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response.
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Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Ruey-Hwa Chen
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
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Polyphosphate attachment to lysine repeats is a non-covalent protein modification Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Nolan Neville, Kirsten Lehotsky, Kody A. Klupt, Michael Downey, Zongchao Jia
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On the covalent nature of lysine polyphosphorylation Mol. Cell (IF 16.0) Pub Date : 2024-05-02 Cristina Azevedo, Filipy Borghi, Xue Bessie Su, Adolfo Saiardi
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Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization Dev. Cell (IF 11.8) Pub Date : 2024-05-02 Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader
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The mitochondrial multi-omic response to exercise training across rat tissues Cell Metab. (IF 29.0) Pub Date : 2024-05-02 David Amar, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A. Gaul, Steven G. Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M. Fernández, Stephen B. Montgomery, Andrea L. Hevener, Euan A. Ashley, Martin J. Walsh, Lauren M. Sparks, Jimmy Zhen
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Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness Cell Metab. (IF 29.0) Pub Date : 2024-05-02 Nesrine S. Rachedi, Ying Tang, Yi-Yin Tai, Jingsi Zhao, Caroline Chauvet, Julien Grynblat, Kouamé Kan Firmin Akoumia, Leonard Estephan, Stéphanie Torrino, Chaima Sbai, Amel Ait-Mouffok, Joseph D. Latoche, Yassmin Al Aaraj, Frederic Brau, Sophie Abélanet, Stephan Clavel, Yingze Zhang, Christelle Guillermier, Naveen V.G. Kumar, Sina Tavakoli, Stephen Y. Chan
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Unveiling the mystery of nuclear RNA homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Lin Shan, Ling-Ling Chen
How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.1 utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.
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Addressing challenges for repairing adult spinal cord with insights from neonates Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Mickey E. Abraham, Joel Martin, Joseph D. Ciacci
Stem cell therapy has emerged as a promising area of scientific investigation, sparking considerable interest, especially in spinal cord injury (SCI). Sun et al.1 discover that the extracellular matrix (ECM) from the neonatal spinal cord transmits biochemical signals to endogenous axons, thus promoting axonal regeneration.
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Actin pushes open a leaky lumen Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Jia Guo, Yue Shao
Using a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al.1 establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.
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Sox9-coordinated cellular neighborhoods generate fibrosis Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Darrian Bugg, Jennifer Davis
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.
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Microbial metabolite steers intestinal stem cell fate under stress Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Shu Zhu, Wen Pan
Recently in Cell Metabolism, Wei et al.1 unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.